Fibrinolysis Profiles and Platelet Activation After Endothelial Cell Seeding of Prosthetic Vascular Grafts
There is no convincing evidence that endothelial cell seeding of prosthetic grafts in humans confers any of the advantages seen in animals. However, partial endothelial coverage might exert a subtle effect not detectable with indirect end points such as patency or scintigraphy. This study examined s...
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| Veröffentlicht in: | Annals of vascular surgery 1995-11, Vol.9 (6), p.542-546 |
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| container_title | Annals of vascular surgery |
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| creator | Smyth, J.V. Welch, M. Carr, H.M.H. Dodd, P.D.F. Eisenberg, P.R. Walker, M.G. |
| description | There is no convincing evidence that endothelial cell seeding of prosthetic grafts in humans confers any of the advantages seen in animals. However, partial endothelial coverage might exert a subtle effect not detectable with indirect end points such as patency or scintigraphy. This study examined seeded cell function by measuring fibrinolytic and platelet activation markers in patients receiving seeded and control prosthetic grafts. Thirty-two patients were randomly assigned to seeded (n = 15) and control (n = 17) groups. Preoperatively and 3, 6, and 12 months postoperatively, plasma levels of fibrinopeptide A (FPA), Bp1–42 fragment, cross-linked fibrin degradation products (XL-FDP), thromboxane A
2, (TXA
2), platelet factor 4 (PF4), and β-thromboglobulin (βTG) were measured. Patients with seeded grafts had significantly lower levels of FPA at 6 and 12 months (
p |
| doi_str_mv | 10.1007/BF02018827 |
| format | Article |
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2, (TXA
2), platelet factor 4 (PF4), and β-thromboglobulin (βTG) were measured. Patients with seeded grafts had significantly lower levels of FPA at 6 and 12 months (
p <0.05) and a significant overall group effect (
p <0.05). These patients also tended to have higher levels of XL-FDP (
p <0.1). No other significant differences were seen. The lower rate of conversion of fibrinogen to fibrin and the trend toward increased fibrinolysis seen in seeded grafts may be due to trie metabolic effects of viable retained seeded cells. Although comparable platelet activation indicates that endothelial coverage remains limited, seeding may exert an antithrombotic influence at the graft surface.</description><identifier>ISSN: 0890-5096</identifier><identifier>EISSN: 1615-5947</identifier><identifier>DOI: 10.1007/BF02018827</identifier><identifier>PMID: 8746831</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Aged ; Blood Coagulation Factors - analysis ; Blood Vessel Prosthesis ; Cell Transplantation ; Endothelium, Vascular - cytology ; Female ; Femoral Artery - surgery ; Follow-Up Studies ; Graft Occlusion, Vascular - blood ; Humans ; Ischemia - surgery ; Leg - blood supply ; Male ; Middle Aged ; Platelet Activation - physiology ; Popliteal Artery - surgery ; Postoperative Complications - blood ; Prosthesis Design ; Surface Properties</subject><ispartof>Annals of vascular surgery, 1995-11, Vol.9 (6), p.542-546</ispartof><rights>1995 Annals of Vascular Surgery, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-f0ee7b4e17ec4f6702628619901e192e46ed1799940204522f7fd7c18309e06a3</citedby><cites>FETCH-LOGICAL-c327t-f0ee7b4e17ec4f6702628619901e192e46ed1799940204522f7fd7c18309e06a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890509606604123$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8746831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smyth, J.V.</creatorcontrib><creatorcontrib>Welch, M.</creatorcontrib><creatorcontrib>Carr, H.M.H.</creatorcontrib><creatorcontrib>Dodd, P.D.F.</creatorcontrib><creatorcontrib>Eisenberg, P.R.</creatorcontrib><creatorcontrib>Walker, M.G.</creatorcontrib><title>Fibrinolysis Profiles and Platelet Activation After Endothelial Cell Seeding of Prosthetic Vascular Grafts</title><title>Annals of vascular surgery</title><addtitle>Ann Vasc Surg</addtitle><description>There is no convincing evidence that endothelial cell seeding of prosthetic grafts in humans confers any of the advantages seen in animals. However, partial endothelial coverage might exert a subtle effect not detectable with indirect end points such as patency or scintigraphy. This study examined seeded cell function by measuring fibrinolytic and platelet activation markers in patients receiving seeded and control prosthetic grafts. Thirty-two patients were randomly assigned to seeded (n = 15) and control (n = 17) groups. Preoperatively and 3, 6, and 12 months postoperatively, plasma levels of fibrinopeptide A (FPA), Bp1–42 fragment, cross-linked fibrin degradation products (XL-FDP), thromboxane A
2, (TXA
2), platelet factor 4 (PF4), and β-thromboglobulin (βTG) were measured. Patients with seeded grafts had significantly lower levels of FPA at 6 and 12 months (
p <0.05) and a significant overall group effect (
p <0.05). These patients also tended to have higher levels of XL-FDP (
p <0.1). No other significant differences were seen. The lower rate of conversion of fibrinogen to fibrin and the trend toward increased fibrinolysis seen in seeded grafts may be due to trie metabolic effects of viable retained seeded cells. Although comparable platelet activation indicates that endothelial coverage remains limited, seeding may exert an antithrombotic influence at the graft surface.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Blood Vessel Prosthesis</subject><subject>Cell Transplantation</subject><subject>Endothelium, Vascular - cytology</subject><subject>Female</subject><subject>Femoral Artery - surgery</subject><subject>Follow-Up Studies</subject><subject>Graft Occlusion, Vascular - blood</subject><subject>Humans</subject><subject>Ischemia - surgery</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Activation - physiology</subject><subject>Popliteal Artery - surgery</subject><subject>Postoperative Complications - blood</subject><subject>Prosthesis Design</subject><subject>Surface Properties</subject><issn>0890-5096</issn><issn>1615-5947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1rGzEURUVpSZy0m-4DWnURmPRJI-tj6RrbCQQaaNLtIGueGhl5JpFkg_99FGzaTVdvcQ-H-y4hXxncMAD1_ccSODCtufpAJkyyaTM1Qn0kE9AGmikYeU4uct4AMK6FPiNnWgmpWzYhm2VYpzCM8ZBDpg9p9CFipnbo6UO0BSMWOnMl7G0J40BnvmCii6EfyzPGYCOdY4z0F2Ifhj909O-KXLMSHP1ts9tFm-gqWV_yZ_LJ25jxy-lekqfl4nF-29z_XN3NZ_eNa7kqjQdEtRbIFDrhpQIuuZbMGGDIDEchsWfKGCPq02LKuVe-V47pFgyCtO0l-Xb0vqTxdYe5dNuQXa1pBxx3uVPKMC5bqOD1EXS1c07ou5cUtjYdOgbd-7Ddv2ErfHWy7tZb7P-ipyVrLo451tf2AVOXXcDB1WESutL1Y_if9g3Lu4Ok</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Smyth, J.V.</creator><creator>Welch, M.</creator><creator>Carr, H.M.H.</creator><creator>Dodd, P.D.F.</creator><creator>Eisenberg, P.R.</creator><creator>Walker, M.G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Fibrinolysis Profiles and Platelet Activation After Endothelial Cell Seeding of Prosthetic Vascular Grafts</title><author>Smyth, J.V. ; Welch, M. ; Carr, H.M.H. ; Dodd, P.D.F. ; Eisenberg, P.R. ; Walker, M.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-f0ee7b4e17ec4f6702628619901e192e46ed1799940204522f7fd7c18309e06a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Blood Vessel Prosthesis</topic><topic>Cell Transplantation</topic><topic>Endothelium, Vascular - cytology</topic><topic>Female</topic><topic>Femoral Artery - surgery</topic><topic>Follow-Up Studies</topic><topic>Graft Occlusion, Vascular - blood</topic><topic>Humans</topic><topic>Ischemia - surgery</topic><topic>Leg - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet Activation - physiology</topic><topic>Popliteal Artery - surgery</topic><topic>Postoperative Complications - blood</topic><topic>Prosthesis Design</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smyth, J.V.</creatorcontrib><creatorcontrib>Welch, M.</creatorcontrib><creatorcontrib>Carr, H.M.H.</creatorcontrib><creatorcontrib>Dodd, P.D.F.</creatorcontrib><creatorcontrib>Eisenberg, P.R.</creatorcontrib><creatorcontrib>Walker, M.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smyth, J.V.</au><au>Welch, M.</au><au>Carr, H.M.H.</au><au>Dodd, P.D.F.</au><au>Eisenberg, P.R.</au><au>Walker, M.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrinolysis Profiles and Platelet Activation After Endothelial Cell Seeding of Prosthetic Vascular Grafts</atitle><jtitle>Annals of vascular surgery</jtitle><addtitle>Ann Vasc Surg</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>9</volume><issue>6</issue><spage>542</spage><epage>546</epage><pages>542-546</pages><issn>0890-5096</issn><eissn>1615-5947</eissn><abstract>There is no convincing evidence that endothelial cell seeding of prosthetic grafts in humans confers any of the advantages seen in animals. However, partial endothelial coverage might exert a subtle effect not detectable with indirect end points such as patency or scintigraphy. This study examined seeded cell function by measuring fibrinolytic and platelet activation markers in patients receiving seeded and control prosthetic grafts. Thirty-two patients were randomly assigned to seeded (n = 15) and control (n = 17) groups. Preoperatively and 3, 6, and 12 months postoperatively, plasma levels of fibrinopeptide A (FPA), Bp1–42 fragment, cross-linked fibrin degradation products (XL-FDP), thromboxane A
2, (TXA
2), platelet factor 4 (PF4), and β-thromboglobulin (βTG) were measured. Patients with seeded grafts had significantly lower levels of FPA at 6 and 12 months (
p <0.05) and a significant overall group effect (
p <0.05). These patients also tended to have higher levels of XL-FDP (
p <0.1). No other significant differences were seen. The lower rate of conversion of fibrinogen to fibrin and the trend toward increased fibrinolysis seen in seeded grafts may be due to trie metabolic effects of viable retained seeded cells. Although comparable platelet activation indicates that endothelial coverage remains limited, seeding may exert an antithrombotic influence at the graft surface.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>8746831</pmid><doi>10.1007/BF02018827</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Blood Coagulation Factors - analysis Blood Vessel Prosthesis Cell Transplantation Endothelium, Vascular - cytology Female Femoral Artery - surgery Follow-Up Studies Graft Occlusion, Vascular - blood Humans Ischemia - surgery Leg - blood supply Male Middle Aged Platelet Activation - physiology Popliteal Artery - surgery Postoperative Complications - blood Prosthesis Design Surface Properties |
| title | Fibrinolysis Profiles and Platelet Activation After Endothelial Cell Seeding of Prosthetic Vascular Grafts |
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