Alzheimer's disease fibroblasts have normal repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique

Cultured fibroblast strains from two normal persons and from two patients with the neurodegeneration of Alzheimer's disease were exposed to the alkylating chemical N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Immediately after exposure and also after a 24-h repair incubation period the sin...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-12, Vol.149 (2), p.355-361
Hauptverfasser:	Kinsella, T J, Dobson, P P, Fornace, Jr, A J, Barrett, S F, Ganges, M B, Robbins, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics DNA - analysis DNA - drug effects DNA Damage DNA Repair Fibroblasts - metabolism Humans Methylnitronitrosoguanidine
Online-Zugang:	Volltext
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