Intrauterine light delivery for photodynamic therapy of the human endometrium
Photodynamic therapy is currently being evaluated as a minimally invasive procedure for endometrial ablation not requiring anaesthesia. Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in...
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| Veröffentlicht in: | Human reproduction (Oxford) 1995-11, Vol.10 (11), p.3067-3072 |
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| container_title | Human reproduction (Oxford) |
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| creator | Fehr, M.K. Madsen, S.J. Svaasand, L.O. Tromberg, B.J. Eusebio, J. Berns, M.W. Tadir, Y. |
| description | Photodynamic therapy is currently being evaluated as a minimally invasive procedure for endometrial ablation not requiring anaesthesia. Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in the design of a light intrauterine device. Post-menopausal ex-vivo uteri showed a significantly lower light penetration depth than pre-menopausal uteri. With a single central diffusing fibre inserted, the fluence rate measured in the uterine wall at the most remote point of the cavity decreased to 1.1 ± 0.4% of that measured at closest proximity, whereas it decreased to only 40.0 ± 9.0% with three fibres. Distension of the uterine cavity with 2 ml of an optically clear fluid increased the fluence rate at the fundus between the fibres at a depth of 2 mm by a factor of 4. We conclude that in normal-sized pre-menopausal uterine cavities, three diffusing fibres will deliver an optical dose above the photodynamic threshold level at a depth of 4 mm, even in the most remote areas, in |
| doi_str_mv | 10.1093/oxfordjournals.humrep.a135851 |
| format | Article |
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Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in the design of a light intrauterine device. Post-menopausal ex-vivo uteri showed a significantly lower light penetration depth than pre-menopausal uteri. With a single central diffusing fibre inserted, the fluence rate measured in the uterine wall at the most remote point of the cavity decreased to 1.1 ± 0.4% of that measured at closest proximity, whereas it decreased to only 40.0 ± 9.0% with three fibres. Distension of the uterine cavity with 2 ml of an optically clear fluid increased the fluence rate at the fundus between the fibres at a depth of 2 mm by a factor of 4. We conclude that in normal-sized pre-menopausal uterine cavities, three diffusing fibres will deliver an optical dose above the photodynamic threshold level at a depth of 4 mm, even in the most remote areas, in <30 min without causing thermal damage. For distorted and elongated cavities, either slight distension of the cavity or the insertion of a fourth diffusing fibre is required.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/oxfordjournals.humrep.a135851</identifier><identifier>PMID: 8747076</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; endometrium ; Endometrium - drug effects ; Endometrium - radiation effects ; Equipment Design ; Evaluation Studies as Topic ; Female ; Fiber Optic Technology - instrumentation ; Genital system. Mammary gland ; Humans ; intrauterine light delivery ; Light ; light dosimetry ; Medical sciences ; Menopause ; Middle Aged ; Photochemotherapy - instrumentation ; Photochemotherapy - methods ; photodynamic therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><ispartof>Human reproduction (Oxford), 1995-11, Vol.10 (11), p.3067-3072</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-48e38e8d4bc5d2d66f7f0304e32e4d38c4f6cccab5ef6dd20eae8af494379603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2942868$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8747076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fehr, M.K.</creatorcontrib><creatorcontrib>Madsen, S.J.</creatorcontrib><creatorcontrib>Svaasand, L.O.</creatorcontrib><creatorcontrib>Tromberg, B.J.</creatorcontrib><creatorcontrib>Eusebio, J.</creatorcontrib><creatorcontrib>Berns, M.W.</creatorcontrib><creatorcontrib>Tadir, Y.</creatorcontrib><title>Intrauterine light delivery for photodynamic therapy of the human endometrium</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Photodynamic therapy is currently being evaluated as a minimally invasive procedure for endometrial ablation not requiring anaesthesia. Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in the design of a light intrauterine device. Post-menopausal ex-vivo uteri showed a significantly lower light penetration depth than pre-menopausal uteri. With a single central diffusing fibre inserted, the fluence rate measured in the uterine wall at the most remote point of the cavity decreased to 1.1 ± 0.4% of that measured at closest proximity, whereas it decreased to only 40.0 ± 9.0% with three fibres. Distension of the uterine cavity with 2 ml of an optically clear fluid increased the fluence rate at the fundus between the fibres at a depth of 2 mm by a factor of 4. We conclude that in normal-sized pre-menopausal uterine cavities, three diffusing fibres will deliver an optical dose above the photodynamic threshold level at a depth of 4 mm, even in the most remote areas, in <30 min without causing thermal damage. For distorted and elongated cavities, either slight distension of the cavity or the insertion of a fourth diffusing fibre is required.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>endometrium</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - radiation effects</subject><subject>Equipment Design</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Fiber Optic Technology - instrumentation</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>intrauterine light delivery</subject><subject>Light</subject><subject>light dosimetry</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Photochemotherapy - instrumentation</subject><subject>Photochemotherapy - methods</subject><subject>photodynamic therapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Mammary gland</topic><topic>Humans</topic><topic>intrauterine light delivery</topic><topic>Light</topic><topic>light dosimetry</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Photochemotherapy - instrumentation</topic><topic>Photochemotherapy - methods</topic><topic>photodynamic therapy</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in the design of a light intrauterine device. Post-menopausal ex-vivo uteri showed a significantly lower light penetration depth than pre-menopausal uteri. With a single central diffusing fibre inserted, the fluence rate measured in the uterine wall at the most remote point of the cavity decreased to 1.1 ± 0.4% of that measured at closest proximity, whereas it decreased to only 40.0 ± 9.0% with three fibres. Distension of the uterine cavity with 2 ml of an optically clear fluid increased the fluence rate at the fundus between the fibres at a depth of 2 mm by a factor of 4. We conclude that in normal-sized pre-menopausal uterine cavities, three diffusing fibres will deliver an optical dose above the photodynamic threshold level at a depth of 4 mm, even in the most remote areas, in <30 min without causing thermal damage. For distorted and elongated cavities, either slight distension of the cavity or the insertion of a fourth diffusing fibre is required.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8747076</pmid><doi>10.1093/oxfordjournals.humrep.a135851</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 1995-11, Vol.10 (11), p.3067-3072 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Biological and medical sciences endometrium Endometrium - drug effects Endometrium - radiation effects Equipment Design Evaluation Studies as Topic Female Fiber Optic Technology - instrumentation Genital system. Mammary gland Humans intrauterine light delivery Light light dosimetry Medical sciences Menopause Middle Aged Photochemotherapy - instrumentation Photochemotherapy - methods photodynamic therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) |
| title | Intrauterine light delivery for photodynamic therapy of the human endometrium |
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