Aberrant proteoglycan composition of the glomerular basement membrane in a patient with Denys-Drash syndrome

To ascertain whether changes in proteoglycans are involved in the pathogenesis of the nephrotic syndrome in Denys-Drash syndrome (DDS), we analysed the glycosaminoglycan (GAG) content and composition of the glomerular basement membrane (GBM) in one child with this disorder and in children of compara...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 1995-12, Vol.10 (12), p.2205-2211
Hauptverfasser:	VAN DEN HEUVEL, L. P. W. J, WESTENEND, P. J, VAN DEN BORN, J, ASSMANN, K. J. M, KNOERS, N, MONNENS, L. A. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Basement Membrane - metabolism Basement Membrane - ultrastructure Biological and medical sciences Child, Preschool Collagen - metabolism Fluorescent Antibody Technique, Indirect Glycosaminoglycans - metabolism Humans Infant Infant, Newborn Kidneys Laminin - metabolism Male Medical sciences Nephrology. Urinary tract diseases Nephrotic Syndrome - complications Nephrotic Syndrome - metabolism Nephrotic Syndrome - pathology Proteinuria - etiology Proteinuria - metabolism Urinary system involvement in other diseases. Miscellaneous
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