Effects of alpha-cyano-4-hydroxycinnamic acid on fatigue and recovery of isolated mouse muscle
Fatigue and recovery of mouse soleus and extensor digitorum longus muscles were investigated in standard saline and in saline containing the lactate + hydrogen ion transport blocker, alpha-cyano-4-hydroxycinnamic acid (cinnamate). The fatigue protocol was a series of brief isometric tetani which red...
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| Veröffentlicht in: | Journal of muscle research and cell motility 1995-12, Vol.16 (6), p.611-617 |
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| container_title | Journal of muscle research and cell motility |
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| creator | Clarke, P D Clift, D L Dooldeniya, M Burnett, C A Curtin, N A |
| description | Fatigue and recovery of mouse soleus and extensor digitorum longus muscles were investigated in standard saline and in saline containing the lactate + hydrogen ion transport blocker, alpha-cyano-4-hydroxycinnamic acid (cinnamate). The fatigue protocol was a series of brief isometric tetani which reduced isometric force by about 25%. Recovery was monitored by test tetani during recovery. Both muscles recovered completely in standard saline. Soleus muscle also recovered completely in the presence of cinnamate, whereas extensor digitorum longus hardly recovered at all. Force during fatigue and recovery can be described in a mathematical simulation in which force depends on intracellular inorganic phosphate and pH, and the only effect of cinnamate is to block lactate + hydrogen ion transport. The results of the simulation suggest that during the fatiguing series of tetani pH changes are small and have a negligible effect on force, but pH is a major determinant of the timecourse of recovery in extensor digitorum longus. |
| doi_str_mv | 10.1007/BF00130242 |
| format | Article |
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The fatigue protocol was a series of brief isometric tetani which reduced isometric force by about 25%. Recovery was monitored by test tetani during recovery. Both muscles recovered completely in standard saline. Soleus muscle also recovered completely in the presence of cinnamate, whereas extensor digitorum longus hardly recovered at all. Force during fatigue and recovery can be described in a mathematical simulation in which force depends on intracellular inorganic phosphate and pH, and the only effect of cinnamate is to block lactate + hydrogen ion transport. 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| ispartof | Journal of muscle research and cell motility, 1995-12, Vol.16 (6), p.611-617 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Coumaric Acids - pharmacology Energy Metabolism - physiology Hydrogen-Ion Concentration Isometric Contraction - physiology Lactates - metabolism Mice Mice, Inbred Strains Muscle Fatigue - drug effects Muscle, Skeletal - physiology Phosphates - metabolism Phosphocreatine - metabolism Space life sciences Time Factors |
| title | Effects of alpha-cyano-4-hydroxycinnamic acid on fatigue and recovery of isolated mouse muscle |
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