B cells are generated throughout life in humans

This analysis of B cell development as a function of age reveals a relatively widespread distribution of progenitor B (pro-B), pre-B, and B cells in fetal tissues, and thus supports the idea of a multifocal origin of B lineage cells during embryonic development. From mid-gestation onward, the bone m...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-01, Vol.156 (2), p.866-872
Hauptverfasser:	Nunez, C, Nishimoto, N, Gartland, GL, Billips, LG, Burrows, PD, Kubagawa, H, Cooper, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging - immunology B-Lymphocytes - cytology B-Lymphocytes - enzymology Base Sequence Biomarkers Bone Marrow - embryology Bone Marrow - growth & development Bone Marrow Cells CD5 Antigens - analysis Cell Lineage Child Clonal Deletion DNA Nucleotidylexotransferase - analysis DNA Nucleotidyltransferases - analysis Gestational Age Hematopoiesis - physiology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology Hematopoietic System - growth & development Humans Immunophenotyping Molecular Sequence Data Receptors, Antigen, B-Cell - analysis VDJ Recombinases Viscera - cytology Viscera - embryology
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