High frequency-induced upregulation of human cardiac calcium currents

In mammalian heart cells, Ca2+ influx through voltage-gated L-type Ca2+ channels can be upregulated by high rates of stimulation. We have investigated this important adaptive regulation in human cardiomyocytes. Using the whole-cell patch-clamp technique, we found a high frequency-induced upregulatio...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996, Vol.93 (1), p.120-128
Hauptverfasser:	PIOT, C, LEMAIRE, S, ALBAT, B, SEGUIN, J, NARGEOT, J, RICHARD, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Calcium - physiology Calcium Channels - metabolism Cardiotonic Agents - pharmacology Cells, Cultured Female Fundamental and applied biological sciences. Psychology Heart Heart - physiology Humans Isoproterenol - pharmacology Male Middle Aged Myocardial Contraction - physiology Patch-Clamp Techniques Up-Regulation Vertebrates: cardiovascular system
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