Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease
We have analysed 11 trials which used quantitative angiography to assess the effects of lipid-lowering therapy on coronary atherosclerosis. Linear regression, weighted for the number of patients studied, showed that the change in per cent diameter stenosis was significantly correlated with per cent...
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| Veröffentlicht in: | Current opinion in lipidology 1995-12, Vol.6 (6), p.386-388 |
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| container_title | Current opinion in lipidology |
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| creator | Thompson, G R Hollyer, J Waters, D D |
| description | We have analysed 11 trials which used quantitative angiography to assess the effects of lipid-lowering therapy on coronary atherosclerosis. Linear regression, weighted for the number of patients studied, showed that the change in per cent diameter stenosis was significantly correlated with per cent reduction in LDL-cholesterol (r = 0.74, p < 0.0005), but not with the LDL-cholesterol concentration during the trials. These findings have important implications for the secondary prevention of coronary heart disease. |
| doi_str_mv | 10.1097/00041433-199512000-00010 |
| format | Article |
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Linear regression, weighted for the number of patients studied, showed that the change in per cent diameter stenosis was significantly correlated with per cent reduction in LDL-cholesterol (r = 0.74, p < 0.0005), but not with the LDL-cholesterol concentration during the trials. 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Linear regression, weighted for the number of patients studied, showed that the change in per cent diameter stenosis was significantly correlated with per cent reduction in LDL-cholesterol (r = 0.74, p < 0.0005), but not with the LDL-cholesterol concentration during the trials. These findings have important implications for the secondary prevention of coronary heart disease.</description><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical Trials as Topic</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - drug therapy</subject><subject>Coronary Disease - mortality</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Linear Models</subject><subject>Lipids - blood</subject><subject>Risk Factors</subject><issn>0957-9672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9PwzAMxXMAjTH4CEg5cSs4TZs0RzT-SpPgAOcoSx1W1DYlaUF8ezI2drCebPn5WT9CKIMrBkpeA0DBCs4zplTJ8tRmqRgckTmoUmZKyPyEnMb4kaa5Ajkjs0qWkJd8Tr5fMFjsR_OO1G5MnySYcYOBjqmjQ2tiZ2iLX9hS7-jqdpXZjW8xjhh8S2tM2jU9Rro1mQGnsbE0YBx8H5E2PbU--N6EH7pBE0ZaNxFNxDNy7Ewb8XyvC_J2f_e6fMxWzw9Py5uUwhmMWW3XsgYmFOdQ1TXksiqkcVZyJwwUQiijCoFWiFoIxyvhqtJACc5VUhiGfEEud3eH4D-n9LbummixbU2PfopaSgVciSotVrtFG3yMAZ0eQtOlvzUDveWs_znrA2f9xzlZL_YZ07rD-mDcQ-a_1ux8bw</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>Thompson, G R</creator><creator>Hollyer, J</creator><creator>Waters, D D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951201</creationdate><title>Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease</title><author>Thompson, G R ; Hollyer, J ; Waters, D D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-dcb7d01693308dd027847afc73f6a04669a946ec66d66f386f85a050ff876a1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical Trials as Topic</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - drug therapy</topic><topic>Coronary Disease - mortality</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Linear Models</topic><topic>Lipids - blood</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, G R</creatorcontrib><creatorcontrib>Hollyer, J</creatorcontrib><creatorcontrib>Waters, D D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in lipidology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, G R</au><au>Hollyer, J</au><au>Waters, D D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease</atitle><jtitle>Current opinion in lipidology</jtitle><addtitle>Curr Opin Lipidol</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>6</volume><issue>6</issue><spage>386</spage><epage>388</epage><pages>386-388</pages><issn>0957-9672</issn><abstract>We have analysed 11 trials which used quantitative angiography to assess the effects of lipid-lowering therapy on coronary atherosclerosis. Linear regression, weighted for the number of patients studied, showed that the change in per cent diameter stenosis was significantly correlated with per cent reduction in LDL-cholesterol (r = 0.74, p < 0.0005), but not with the LDL-cholesterol concentration during the trials. These findings have important implications for the secondary prevention of coronary heart disease.</abstract><cop>England</cop><pmid>8750253</pmid><doi>10.1097/00041433-199512000-00010</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0957-9672 |
| ispartof | Current opinion in lipidology, 1995-12, Vol.6 (6), p.386-388 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Anticholesteremic Agents - therapeutic use Cholesterol, LDL - blood Clinical Trials as Topic Coronary Angiography Coronary Disease - drug therapy Coronary Disease - mortality Humans Hyperlipidemias - blood Hyperlipidemias - drug therapy Linear Models Lipids - blood Risk Factors |
| title | Percentage change rather than plasma level of LDL-cholesterol determines therapeutic response in coronary heart disease |
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