Overexpression of cyclin D1 enhances gene amplification
Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic o...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1996, Vol.56 (1), p.36-39 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | PING ZHOU WEI JIANG WEGHORST, C. M WEINSTEIN, I. B |
| description | Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin D1 in a rat liver epithelial cell line markedly increased the yield of cells containing amplified copies of the CAD gene. This effect was associated with a loss of G1-S checkpoint control, although the cyclin D1-overexpressing cells had a normal p53 gene. The capacity of cyclin D1 to enhance gene amplification may contribute to the process of genomic instability during tumor development. |
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M ; WEINSTEIN, I. B</creator><creatorcontrib>PING ZHOU ; WEI JIANG ; WEGHORST, C. M ; WEINSTEIN, I. B</creatorcontrib><description>Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin D1 in a rat liver epithelial cell line markedly increased the yield of cells containing amplified copies of the CAD gene. This effect was associated with a loss of G1-S checkpoint control, although the cyclin D1-overexpressing cells had a normal p53 gene. The capacity of cyclin D1 to enhance gene amplification may contribute to the process of genomic instability during tumor development.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8548770</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Aspartate Carbamoyltransferase - biosynthesis ; Aspartate Carbamoyltransferase - genetics ; Biological and medical sciences ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - biosynthesis ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - genetics ; Cell Cycle - genetics ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cells, Cultured ; Cyclin D1 ; Cyclins - biosynthesis ; Cyclins - genetics ; Dihydroorotase - biosynthesis ; Dihydroorotase - genetics ; Epithelial Cells ; Epithelium - metabolism ; Fundamental and applied biological sciences. 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M</creatorcontrib><creatorcontrib>WEINSTEIN, I. B</creatorcontrib><title>Overexpression of cyclin D1 enhances gene amplification</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin D1 in a rat liver epithelial cell line markedly increased the yield of cells containing amplified copies of the CAD gene. This effect was associated with a loss of G1-S checkpoint control, although the cyclin D1-overexpressing cells had a normal p53 gene. The capacity of cyclin D1 to enhance gene amplification may contribute to the process of genomic instability during tumor development.</description><subject>Animals</subject><subject>Aspartate Carbamoyltransferase - biosynthesis</subject><subject>Aspartate Carbamoyltransferase - genetics</subject><subject>Biological and medical sciences</subject><subject>Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - biosynthesis</subject><subject>Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - genetics</subject><subject>Cell Cycle - genetics</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cells, Cultured</subject><subject>Cyclin D1</subject><subject>Cyclins - biosynthesis</subject><subject>Cyclins - genetics</subject><subject>Dihydroorotase - biosynthesis</subject><subject>Dihydroorotase - genetics</subject><subject>Epithelial Cells</subject><subject>Epithelium - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Dosage</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Multienzyme Complexes - biosynthesis</subject><subject>Multienzyme Complexes - genetics</subject><subject>Oncogene Proteins - biosynthesis</subject><subject>Oncogene Proteins - genetics</subject><subject>Rats</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAgyrqu_gShB_FWmDYfkxxl_YSFvei5pMnEjfTLZlfcf2_B4tXTMLwPA_OesGUhuc5RCHnKlgCgcymwPGcXKX1MqyxALthCS6ERYclw-0UjfQ8jpRT7LutD5o6uiV12X2TU7WznKGXv1FFm26GJITq7n-AlOwu2SXQ1zxV7e3x4XT_nm-3Ty_puk-9Kg_vceFQoVGm8CMI50KHWUCvnySurQilK0JIrLnjNva05eoseUFlwhdEQ-Ird_t4dxv7zQGlftTE5ahrbUX9IFaIBzlH_CwsptQGNE7ye4aFuyVfDGFs7Hqu5kim_mXObnG3COFUQ0x-b3pKFQf4D0hJpmg</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>PING ZHOU</creator><creator>WEI JIANG</creator><creator>WEGHORST, C. 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B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h297t-9d7674629d4f4cc08fb80b6cded6a6f24208536343b3dab37da7d076a0c1980f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Aspartate Carbamoyltransferase - biosynthesis</topic><topic>Aspartate Carbamoyltransferase - genetics</topic><topic>Biological and medical sciences</topic><topic>Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - biosynthesis</topic><topic>Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - genetics</topic><topic>Cell Cycle - genetics</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Cells, Cultured</topic><topic>Cyclin D1</topic><topic>Cyclins - biosynthesis</topic><topic>Cyclins - genetics</topic><topic>Dihydroorotase - biosynthesis</topic><topic>Dihydroorotase - genetics</topic><topic>Epithelial Cells</topic><topic>Epithelium - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Dosage</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Multienzyme Complexes - biosynthesis</topic><topic>Multienzyme Complexes - genetics</topic><topic>Oncogene Proteins - biosynthesis</topic><topic>Oncogene Proteins - genetics</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PING ZHOU</creatorcontrib><creatorcontrib>WEI JIANG</creatorcontrib><creatorcontrib>WEGHORST, C. M</creatorcontrib><creatorcontrib>WEINSTEIN, I. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of cyclin D1 enhances gene amplification</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1996</date><risdate>1996</risdate><volume>56</volume><issue>1</issue><spage>36</spage><epage>39</epage><pages>36-39</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin D1 in a rat liver epithelial cell line markedly increased the yield of cells containing amplified copies of the CAD gene. This effect was associated with a loss of G1-S checkpoint control, although the cyclin D1-overexpressing cells had a normal p53 gene. The capacity of cyclin D1 to enhance gene amplification may contribute to the process of genomic instability during tumor development.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8548770</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1996, Vol.56 (1), p.36-39 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77903378 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Aspartate Carbamoyltransferase - biosynthesis Aspartate Carbamoyltransferase - genetics Biological and medical sciences Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - biosynthesis Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - genetics Cell Cycle - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cyclin D1 Cyclins - biosynthesis Cyclins - genetics Dihydroorotase - biosynthesis Dihydroorotase - genetics Epithelial Cells Epithelium - metabolism Fundamental and applied biological sciences. Psychology Gene Dosage Gene Expression Regulation Humans Liver - metabolism Molecular and cellular biology Multienzyme Complexes - biosynthesis Multienzyme Complexes - genetics Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Rats |
| title | Overexpression of cyclin D1 enhances gene amplification |
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