Protection of MN-rgp120-Immunized Chimpanzees from Heterologous Infection with a Primary Isolate of Human Immunodeficiency Virus Type 1
Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and mul...
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| Veröffentlicht in: | The Journal of infectious diseases 1996-01, Vol.173 (1), p.52-59 |
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| creator | Berman, Phillip W. Murthy, Krishna K. Wrin, Terri Vennari, Joann C. Cobb, E. Kathy Eastman, Donna J. Champe, Mark Nakamura, Gerald R. Davison, Donna Powell, Michael F. Bussiere, Jeanine Francis, Donald P. Matthews, Tom Gregory, Timothy J. Obijeski, John F. |
| description | Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic assays beginning 2 weeks after infection. Markers of HIV-1 infection were not detected in any of the gp120-vaccinated animals during 12 months of follow-up. Antisera from the gp120-immunized chimpanzees were unable to neutralize the challenge virus cultured in peripheral blood mononuclear cells (PBMC). These studies demonstrate that immunization with recombinant gp120derived from a T cell-adapted isolate prevented infection by a heterologous primary isolate of HIV-1. The results suggest that in vitro virus neutralization assays utilizing primary isolates cultured in PBMC may be imperfect indicators of protection in vivo. |
| doi_str_mv | 10.1093/infdis/173.1.52 |
| format | Article |
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Kathy ; Eastman, Donna J. ; Champe, Mark ; Nakamura, Gerald R. ; Davison, Donna ; Powell, Michael F. ; Bussiere, Jeanine ; Francis, Donald P. ; Matthews, Tom ; Gregory, Timothy J. ; Obijeski, John F.</creator><creatorcontrib>Berman, Phillip W. ; Murthy, Krishna K. ; Wrin, Terri ; Vennari, Joann C. ; Cobb, E. Kathy ; Eastman, Donna J. ; Champe, Mark ; Nakamura, Gerald R. ; Davison, Donna ; Powell, Michael F. ; Bussiere, Jeanine ; Francis, Donald P. ; Matthews, Tom ; Gregory, Timothy J. ; Obijeski, John F.</creatorcontrib><description>Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic assays beginning 2 weeks after infection. Markers of HIV-1 infection were not detected in any of the gp120-vaccinated animals during 12 months of follow-up. Antisera from the gp120-immunized chimpanzees were unable to neutralize the challenge virus cultured in peripheral blood mononuclear cells (PBMC). These studies demonstrate that immunization with recombinant gp120derived from a T cell-adapted isolate prevented infection by a heterologous primary isolate of HIV-1. The results suggest that in vitro virus neutralization assays utilizing primary isolates cultured in PBMC may be imperfect indicators of protection in vivo.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/173.1.52</identifier><identifier>PMID: 8537682</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS Vaccines ; AIDS/HIV ; Animals ; Base Sequence ; Biological and medical sciences ; DNA Primers - chemistry ; DNA, Viral - analysis ; HIV Antibodies - analysis ; HIV Antigens - immunology ; HIV Envelope Protein gp120 - immunology ; HIV Infections - immunology ; HIV Infections - prevention & control ; HIV-1 - genetics ; HIV-1 - immunology ; HIV-1 - isolation & purification ; human immunodeficiency virus 1 ; Immunization ; Immunization Schedule ; Immunization, Secondary ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Medical sciences ; Molecular Sequence Data ; Neutralization Tests ; Pan troglodytes ; T-Lymphocytes - virology ; Vaccines, Synthetic ; Virus Cultivation</subject><ispartof>The Journal of infectious diseases, 1996-01, Vol.173 (1), p.52-59</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-3b7aa563119d4cb6f89ec69c2ae3f32b1b034c349491ffa6ed757b839d9448e83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2995928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8537682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berman, Phillip W.</creatorcontrib><creatorcontrib>Murthy, Krishna K.</creatorcontrib><creatorcontrib>Wrin, Terri</creatorcontrib><creatorcontrib>Vennari, Joann C.</creatorcontrib><creatorcontrib>Cobb, E. Kathy</creatorcontrib><creatorcontrib>Eastman, Donna J.</creatorcontrib><creatorcontrib>Champe, Mark</creatorcontrib><creatorcontrib>Nakamura, Gerald R.</creatorcontrib><creatorcontrib>Davison, Donna</creatorcontrib><creatorcontrib>Powell, Michael F.</creatorcontrib><creatorcontrib>Bussiere, Jeanine</creatorcontrib><creatorcontrib>Francis, Donald P.</creatorcontrib><creatorcontrib>Matthews, Tom</creatorcontrib><creatorcontrib>Gregory, Timothy J.</creatorcontrib><creatorcontrib>Obijeski, John F.</creatorcontrib><title>Protection of MN-rgp120-Immunized Chimpanzees from Heterologous Infection with a Primary Isolate of Human Immunodeficiency Virus Type 1</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic assays beginning 2 weeks after infection. Markers of HIV-1 infection were not detected in any of the gp120-vaccinated animals during 12 months of follow-up. Antisera from the gp120-immunized chimpanzees were unable to neutralize the challenge virus cultured in peripheral blood mononuclear cells (PBMC). These studies demonstrate that immunization with recombinant gp120derived from a T cell-adapted isolate prevented infection by a heterologous primary isolate of HIV-1. The results suggest that in vitro virus neutralization assays utilizing primary isolates cultured in PBMC may be imperfect indicators of protection in vivo.</description><subject>AIDS Vaccines</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA Primers - chemistry</subject><subject>DNA, Viral - analysis</subject><subject>HIV Antibodies - analysis</subject><subject>HIV Antigens - immunology</subject><subject>HIV Envelope Protein gp120 - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - prevention & control</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - isolation & purification</subject><subject>human immunodeficiency virus 1</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunization, Secondary</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Neutralization Tests</subject><subject>Pan troglodytes</subject><subject>T-Lymphocytes - virology</subject><subject>Vaccines, Synthetic</subject><subject>Virus Cultivation</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAURSMEKkNhzQrJQohdZvyR2PESjYCMaGFUlQqxsRznuXVJ4mAngukf4G-TIaELNqy8uOce6folyXOC1wRLtnGdrV3cEMHWZJ3TB8mK5EyknBP2MFlhTGlKCikfJ09ivMUYZ4yLk-SkmCBe0FXyax_8AGZwvkPeovOPabjuCcXprm3Hzt1BjbY3ru11dwcQkQ2-RSUMEHzjr_0Y0a6zS_2HG26QRvvgWh0OaBd9owc4Wsux1R36Y_Q1WGccdOaArlyYBJeHHhB5mjyyuonwbHlPk8_v3l5uy_Ts0_vd9s1ZajKOh5RVQuucM0JknZmK20KC4dJQDcwyWpEKs8ywTGaSWKs51CIXVcFkLbOsgIKdJq9nbx_89xHioFoXDTSN7mCao4SQmGEq_wsSgXNc8GwCX_4D3voxdNMIRSmTpOBMTNBmhkzwMQawqp-_SRGsjodU8yEnLVNE5XRqvFi0Y9VCfc8vl5vyV0uuo9GNDbozU_8vRqXMJT3uTWfMxQF-3sc6fFNcMJGr8stXdfVhX2YXF-eqYL8BS_i3Fg</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Berman, Phillip W.</creator><creator>Murthy, Krishna K.</creator><creator>Wrin, Terri</creator><creator>Vennari, Joann C.</creator><creator>Cobb, E. 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Kathy ; Eastman, Donna J. ; Champe, Mark ; Nakamura, Gerald R. ; Davison, Donna ; Powell, Michael F. ; Bussiere, Jeanine ; Francis, Donald P. ; Matthews, Tom ; Gregory, Timothy J. ; Obijeski, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-3b7aa563119d4cb6f89ec69c2ae3f32b1b034c349491ffa6ed757b839d9448e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS Vaccines</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA Primers - chemistry</topic><topic>DNA, Viral - analysis</topic><topic>HIV Antibodies - analysis</topic><topic>HIV Antigens - immunology</topic><topic>HIV Envelope Protein gp120 - immunology</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - prevention & control</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 - isolation & purification</topic><topic>human immunodeficiency virus 1</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Immunization, Secondary</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Neutralization Tests</topic><topic>Pan troglodytes</topic><topic>T-Lymphocytes - virology</topic><topic>Vaccines, Synthetic</topic><topic>Virus Cultivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berman, Phillip W.</creatorcontrib><creatorcontrib>Murthy, Krishna K.</creatorcontrib><creatorcontrib>Wrin, Terri</creatorcontrib><creatorcontrib>Vennari, Joann C.</creatorcontrib><creatorcontrib>Cobb, E. 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Kathy</au><au>Eastman, Donna J.</au><au>Champe, Mark</au><au>Nakamura, Gerald R.</au><au>Davison, Donna</au><au>Powell, Michael F.</au><au>Bussiere, Jeanine</au><au>Francis, Donald P.</au><au>Matthews, Tom</au><au>Gregory, Timothy J.</au><au>Obijeski, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of MN-rgp120-Immunized Chimpanzees from Heterologous Infection with a Primary Isolate of Human Immunodeficiency Virus Type 1</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-01</date><risdate>1996</risdate><volume>173</volume><issue>1</issue><spage>52</spage><epage>59</epage><pages>52-59</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic assays beginning 2 weeks after infection. Markers of HIV-1 infection were not detected in any of the gp120-vaccinated animals during 12 months of follow-up. Antisera from the gp120-immunized chimpanzees were unable to neutralize the challenge virus cultured in peripheral blood mononuclear cells (PBMC). These studies demonstrate that immunization with recombinant gp120derived from a T cell-adapted isolate prevented infection by a heterologous primary isolate of HIV-1. The results suggest that in vitro virus neutralization assays utilizing primary isolates cultured in PBMC may be imperfect indicators of protection in vivo.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8537682</pmid><doi>10.1093/infdis/173.1.52</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1996-01, Vol.173 (1), p.52-59 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | AIDS Vaccines AIDS/HIV Animals Base Sequence Biological and medical sciences DNA Primers - chemistry DNA, Viral - analysis HIV Antibodies - analysis HIV Antigens - immunology HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV Infections - prevention & control HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification human immunodeficiency virus 1 Immunization Immunization Schedule Immunization, Secondary Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Medical sciences Molecular Sequence Data Neutralization Tests Pan troglodytes T-Lymphocytes - virology Vaccines, Synthetic Virus Cultivation |
| title | Protection of MN-rgp120-Immunized Chimpanzees from Heterologous Infection with a Primary Isolate of Human Immunodeficiency Virus Type 1 |
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