Neutralization of Macrophage Inflammatory Protein-2 Attenuates Neutrophil Recruitment and Bacterial Clearance in Murine Klebsiella Pneumonia

The role of macrophage inflammatory protein-2 (MIP-2) in bacterial pneumonia was characterized. Mice were challenged with Klebsiella pneumoniae intratracheally, and organs were harvested at 8, 24, and 48 h. Inoculation with K. pneumoniae resulted in the time-dependent expression of MIP-2 mRNA and pr...

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Veröffentlicht in:	The Journal of infectious diseases 1996-01, Vol.173 (1), p.159-165
Hauptverfasser:	Greenberger, Marc J., Strieter, Robert M., Kunkel, Steven L., Danforth, Jean M., Laichalk, Lauri L., McGillicuddy, Daniel C., Standiford, Theodore J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Bacteremia - microbiology Bacterial diseases Bacterial pneumonia Base Sequence Biological and medical sciences Chemokine CXCL2 Chemotactic Factors - biosynthesis Chemotactic Factors - genetics Chemotactic Factors - immunology Chemotaxis, Leukocyte - immunology Colony Count, Microbial Cytokines Cytokines - biosynthesis Cytokines - genetics Cytokines - immunology DNA Primers - chemistry Experimental bacterial diseases and models Female Immunization, Passive Immunoenzyme Techniques Infectious diseases Inoculation Klebsiella Klebsiella Infections - immunology Klebsiella Infections - microbiology Klebsiella Infections - pathology Klebsiella pneumoniae Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - physiology Liver - microbiology Liver - pathology Lung - metabolism Lung - microbiology Lung - pathology Lungs Macrophages Medical sciences Messenger RNA Mice Molecular Sequence Data Monokines - biosynthesis Monokines - genetics Monokines - immunology Neutrophils - immunology Peroxidase - metabolism Pneumonia Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - pathology Polymerase Chain Reaction RNA, Messenger - biosynthesis Specific Pathogen-Free Organisms Time Factors
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