Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro
Many flavonoids extracted from higher plants, synthesized or purified flavonoids, and their aglycones showed anti-tumor activity. Using purified or synthesized flavonoids, we studied the effect of the chemical structure of 2-benzoic flavone on the growth of human tumor cells (HCT-15 in vitro. The ty...
Gespeichert in:
| Veröffentlicht in: | Cancer biotherapy & radiopharmaceuticals 1996-08, Vol.11 (4), p.247-249 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 4 |
| container_start_page | 247 |
| container_title | Cancer biotherapy & radiopharmaceuticals |
| container_volume | 11 |
| creator | KAMEI, H KOJIMA, T KOIDE, T HASEGAWA, M UMEDA, T TERABA, K HASHIMOTO, Y |
| description | Many flavonoids extracted from higher plants, synthesized or purified flavonoids, and their aglycones showed anti-tumor activity. Using purified or synthesized flavonoids, we studied the effect of the chemical structure of 2-benzoic flavone on the growth of human tumor cells (HCT-15 in vitro. The type of sugar combined with the A phenol of flavonoids played an important role in the tumor suppression; i.e., glucose attachment at the A phenol caused suppression of tumor cell growth, but other sugars such as rhamnose and lutinoside at that position did not suppress the growth of the cells. OH groups bonded to the B phenol also had a great effect on the growth. Flavonoids with OH groups conjugated to the 3', 4', and 5' of B phenol were stronger in anti-tumor effect than those with the OH groups attached at the 3' and 4' or 4' only, although anthocyanins were generally more effective than the other flavonoids. |
| doi_str_mv | 10.1089/cbr.1996.11.247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77900449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77900449</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-3c0e71ff903cae69b141816ba0e4cef9699e2de965db01e511c4ff913be4c3ad3</originalsourceid><addsrcrecordid>eNpNkE1LxDAQhoMofp-9SQ7irWumTdPmKIsfCwt70XNI04lWuklN2hX_vVl2UU-T4X3mhTyEXAGbAavlnWnCDKQUM4BZzqsDcgplWWV1XeaH6c1qnsmqLk_IWYwfjDHBRHVMTlJQQsn5KfELZ_sJnUHqLV0907fgp4Fq19I4velAG-9abOnoqe31xjvftZF697dla2w7PeL2YBgCxtilOJWN09qHbd_X-E47RzfdGPwFObK6j3i5n-fk9fHhZf6cLVdPi_n9MjNFno9ZYRhWYK1khdEoZAMcahCNZsgNWimkxLxFKcq2YYAlgOGJhqJJeaHb4pzc7nqH4D8njKNad9Fg32uHfoqqqiRjnMsE3u1AE3yMAa0aQrfW4VsBU1vHKjlWW8cKQCXH6eJ6Xz016e__-J3UBNzsAR2N7m3QznTxlytywSshix8iG4bh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77900449</pqid></control><display><type>article</type><title>Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>KAMEI, H ; KOJIMA, T ; KOIDE, T ; HASEGAWA, M ; UMEDA, T ; TERABA, K ; HASHIMOTO, Y</creator><creatorcontrib>KAMEI, H ; KOJIMA, T ; KOIDE, T ; HASEGAWA, M ; UMEDA, T ; TERABA, K ; HASHIMOTO, Y</creatorcontrib><description>Many flavonoids extracted from higher plants, synthesized or purified flavonoids, and their aglycones showed anti-tumor activity. Using purified or synthesized flavonoids, we studied the effect of the chemical structure of 2-benzoic flavone on the growth of human tumor cells (HCT-15 in vitro. The type of sugar combined with the A phenol of flavonoids played an important role in the tumor suppression; i.e., glucose attachment at the A phenol caused suppression of tumor cell growth, but other sugars such as rhamnose and lutinoside at that position did not suppress the growth of the cells. OH groups bonded to the B phenol also had a great effect on the growth. Flavonoids with OH groups conjugated to the 3', 4', and 5' of B phenol were stronger in anti-tumor effect than those with the OH groups attached at the 3' and 4' or 4' only, although anthocyanins were generally more effective than the other flavonoids.</description><identifier>ISSN: 1084-9785</identifier><identifier>EISSN: 1557-8852</identifier><identifier>DOI: 10.1089/cbr.1996.11.247</identifier><identifier>PMID: 10851544</identifier><identifier>CODEN: CBRAFJ</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Antineoplastic agents ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Flavonoids - pharmacology ; General aspects ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Structure-Activity Relationship ; Tumor Cells, Cultured</subject><ispartof>Cancer biotherapy & radiopharmaceuticals, 1996-08, Vol.11 (4), p.247-249</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-3c0e71ff903cae69b141816ba0e4cef9699e2de965db01e511c4ff913be4c3ad3</citedby><cites>FETCH-LOGICAL-c322t-3c0e71ff903cae69b141816ba0e4cef9699e2de965db01e511c4ff913be4c3ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3028,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3264769$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10851544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMEI, H</creatorcontrib><creatorcontrib>KOJIMA, T</creatorcontrib><creatorcontrib>KOIDE, T</creatorcontrib><creatorcontrib>HASEGAWA, M</creatorcontrib><creatorcontrib>UMEDA, T</creatorcontrib><creatorcontrib>TERABA, K</creatorcontrib><creatorcontrib>HASHIMOTO, Y</creatorcontrib><title>Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro</title><title>Cancer biotherapy & radiopharmaceuticals</title><addtitle>Cancer Biother Radiopharm</addtitle><description>Many flavonoids extracted from higher plants, synthesized or purified flavonoids, and their aglycones showed anti-tumor activity. Using purified or synthesized flavonoids, we studied the effect of the chemical structure of 2-benzoic flavone on the growth of human tumor cells (HCT-15 in vitro. The type of sugar combined with the A phenol of flavonoids played an important role in the tumor suppression; i.e., glucose attachment at the A phenol caused suppression of tumor cell growth, but other sugars such as rhamnose and lutinoside at that position did not suppress the growth of the cells. OH groups bonded to the B phenol also had a great effect on the growth. Flavonoids with OH groups conjugated to the 3', 4', and 5' of B phenol were stronger in anti-tumor effect than those with the OH groups attached at the 3' and 4' or 4' only, although anthocyanins were generally more effective than the other flavonoids.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Flavonoids - pharmacology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Structure-Activity Relationship</subject><subject>Tumor Cells, Cultured</subject><issn>1084-9785</issn><issn>1557-8852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1LxDAQhoMofp-9SQ7irWumTdPmKIsfCwt70XNI04lWuklN2hX_vVl2UU-T4X3mhTyEXAGbAavlnWnCDKQUM4BZzqsDcgplWWV1XeaH6c1qnsmqLk_IWYwfjDHBRHVMTlJQQsn5KfELZ_sJnUHqLV0907fgp4Fq19I4velAG-9abOnoqe31xjvftZF697dla2w7PeL2YBgCxtilOJWN09qHbd_X-E47RzfdGPwFObK6j3i5n-fk9fHhZf6cLVdPi_n9MjNFno9ZYRhWYK1khdEoZAMcahCNZsgNWimkxLxFKcq2YYAlgOGJhqJJeaHb4pzc7nqH4D8njKNad9Fg32uHfoqqqiRjnMsE3u1AE3yMAa0aQrfW4VsBU1vHKjlWW8cKQCXH6eJ6Xz016e__-J3UBNzsAR2N7m3QznTxlytywSshix8iG4bh</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>KAMEI, H</creator><creator>KOJIMA, T</creator><creator>KOIDE, T</creator><creator>HASEGAWA, M</creator><creator>UMEDA, T</creator><creator>TERABA, K</creator><creator>HASHIMOTO, Y</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro</title><author>KAMEI, H ; KOJIMA, T ; KOIDE, T ; HASEGAWA, M ; UMEDA, T ; TERABA, K ; HASHIMOTO, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-3c0e71ff903cae69b141816ba0e4cef9699e2de965db01e511c4ff913be4c3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Flavonoids - pharmacology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Structure-Activity Relationship</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAMEI, H</creatorcontrib><creatorcontrib>KOJIMA, T</creatorcontrib><creatorcontrib>KOIDE, T</creatorcontrib><creatorcontrib>HASEGAWA, M</creatorcontrib><creatorcontrib>UMEDA, T</creatorcontrib><creatorcontrib>TERABA, K</creatorcontrib><creatorcontrib>HASHIMOTO, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biotherapy & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAMEI, H</au><au>KOJIMA, T</au><au>KOIDE, T</au><au>HASEGAWA, M</au><au>UMEDA, T</au><au>TERABA, K</au><au>HASHIMOTO, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro</atitle><jtitle>Cancer biotherapy & radiopharmaceuticals</jtitle><addtitle>Cancer Biother Radiopharm</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>11</volume><issue>4</issue><spage>247</spage><epage>249</epage><pages>247-249</pages><issn>1084-9785</issn><eissn>1557-8852</eissn><coden>CBRAFJ</coden><abstract>Many flavonoids extracted from higher plants, synthesized or purified flavonoids, and their aglycones showed anti-tumor activity. Using purified or synthesized flavonoids, we studied the effect of the chemical structure of 2-benzoic flavone on the growth of human tumor cells (HCT-15 in vitro. The type of sugar combined with the A phenol of flavonoids played an important role in the tumor suppression; i.e., glucose attachment at the A phenol caused suppression of tumor cell growth, but other sugars such as rhamnose and lutinoside at that position did not suppress the growth of the cells. OH groups bonded to the B phenol also had a great effect on the growth. Flavonoids with OH groups conjugated to the 3', 4', and 5' of B phenol were stronger in anti-tumor effect than those with the OH groups attached at the 3' and 4' or 4' only, although anthocyanins were generally more effective than the other flavonoids.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>10851544</pmid><doi>10.1089/cbr.1996.11.247</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1084-9785 |
| ispartof | Cancer biotherapy & radiopharmaceuticals, 1996-08, Vol.11 (4), p.247-249 |
| issn | 1084-9785 1557-8852 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77900449 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Flavonoids - pharmacology General aspects Humans Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured |
| title | Influence of OH group and sugar bonded to flavonoids on flavonoid-mediated suppression of tumor growth in vitro |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T20%3A35%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20OH%20group%20and%20sugar%20bonded%20to%20flavonoids%20on%20flavonoid-mediated%20suppression%20of%20tumor%20growth%20in%20vitro&rft.jtitle=Cancer%20biotherapy%20&%20radiopharmaceuticals&rft.au=KAMEI,%20H&rft.date=1996-08-01&rft.volume=11&rft.issue=4&rft.spage=247&rft.epage=249&rft.pages=247-249&rft.issn=1084-9785&rft.eissn=1557-8852&rft.coden=CBRAFJ&rft_id=info:doi/10.1089/cbr.1996.11.247&rft_dat=%3Cproquest_cross%3E77900449%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77900449&rft_id=info:pmid/10851544&rfr_iscdi=true |