Drug Release from Hydrophilic Matrices. 1. New Scaling Laws for Predicting Polymer and Drug Release Based on the Polymer Disentanglement Concentration and the Diffusion Layer

Two scaling laws for predicting polymer and drug release profiles from hydrophilic matrices were developed. They were developed on the basis of the diffusion layer and the polymer disentanglement concentration, ρp,dis, the critical polymer concentration below which polymer chains detach off a gelled...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1995-12, Vol.84 (12), p.1455-1463
Hauptverfasser:	Ju, Robert T.C., Nixon, Phillip R., Patel, Mahesh V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzodiazepines - chemistry Chemistry, Pharmaceutical Delayed-Action Preparations - chemistry Hypromellose Derivatives Methylcellulose - analogs & derivatives Methylcellulose - chemistry Models, Chemical Molecular Weight Solubility Tablets - chemistry Theophylline - chemistry
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