Nucleic acid content and residue determination in tissues of chicks born from 2,4-dichlorophenoxyacetic butyl ester treated eggs
The effects of 2,4-dichlorophenoxyacetic butyl ester (2,4-D b.e.) on protein and nucleic acid contents of different tissues of chicks born from externally treated hen's eggs were studied. Residues of 2,4-D b.e. were also determined and quantified by gas liquid chromatography (GLC). A diminished...
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| Veröffentlicht in: | Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 1987, Vol.10 (3-4), p.339-355 |
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| container_title | Drug and chemical toxicology (New York, N.Y. 1978) |
| container_volume | 10 |
| creator | Duffard, R O Fabra de Peretti, A I Castro de Cantarini, S M Mori de Moro, G B Argüello, J M Evangelista de Duffard, A M |
| description | The effects of 2,4-dichlorophenoxyacetic butyl ester (2,4-D b.e.) on protein and nucleic acid contents of different tissues of chicks born from externally treated hen's eggs were studied. Residues of 2,4-D b.e. were also determined and quantified by gas liquid chromatography (GLC). A diminished DNA content was observed in skeletal muscle and stomach, an increased one was found in cerebrum and cerebellum, whereas no variations were observed in the other analysed tissues. Protein levels were found decreased in kidney, cerebrum and heart. Besides, the GLC determinations revealed the presence of the 2,4-D b.e. in all the studied tissues finding the highest concentrations in kidney. 2,4-D did not appear to be a significant metabolite of 2,4-D b.e. in this experimental system. The dissimilar effects of 2,4-D b.e. on protein and nucleic acid contents of the studied tissues would be related to a different tissue susceptibility to the drug and/or to drug distribution. |
| doi_str_mv | 10.3109/01480548709042991 |
| format | Article |
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Residues of 2,4-D b.e. were also determined and quantified by gas liquid chromatography (GLC). A diminished DNA content was observed in skeletal muscle and stomach, an increased one was found in cerebrum and cerebellum, whereas no variations were observed in the other analysed tissues. Protein levels were found decreased in kidney, cerebrum and heart. Besides, the GLC determinations revealed the presence of the 2,4-D b.e. in all the studied tissues finding the highest concentrations in kidney. 2,4-D did not appear to be a significant metabolite of 2,4-D b.e. in this experimental system. The dissimilar effects of 2,4-D b.e. on protein and nucleic acid contents of the studied tissues would be related to a different tissue susceptibility to the drug and/or to drug distribution.</description><identifier>ISSN: 0148-0545</identifier><identifier>DOI: 10.3109/01480548709042991</identifier><identifier>PMID: 2448113</identifier><language>eng</language><publisher>United States</publisher><subject>2,4-Dichlorophenoxyacetic Acid - analogs & derivatives ; 2,4-Dichlorophenoxyacetic Acid - analysis ; 2,4-Dichlorophenoxyacetic Acid - blood ; 2,4-Dichlorophenoxyacetic Acid - pharmacology ; Animals ; Brain - drug effects ; Brain - embryology ; Chick Embryo ; DNA - analysis ; Heart - drug effects ; Heart - embryology ; Kidney - drug effects ; Kidney - embryology ; Liver - drug effects ; Liver - embryology ; Proteins - analysis ; RNA - analysis ; Stomach - drug effects ; Stomach - embryology</subject><ispartof>Drug and chemical toxicology (New York, N.Y. 1978), 1987, Vol.10 (3-4), p.339-355</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2448113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duffard, R O</creatorcontrib><creatorcontrib>Fabra de Peretti, A I</creatorcontrib><creatorcontrib>Castro de Cantarini, S M</creatorcontrib><creatorcontrib>Mori de Moro, G B</creatorcontrib><creatorcontrib>Argüello, J M</creatorcontrib><creatorcontrib>Evangelista de Duffard, A M</creatorcontrib><title>Nucleic acid content and residue determination in tissues of chicks born from 2,4-dichlorophenoxyacetic butyl ester treated eggs</title><title>Drug and chemical toxicology (New York, N.Y. 1978)</title><addtitle>Drug Chem Toxicol</addtitle><description>The effects of 2,4-dichlorophenoxyacetic butyl ester (2,4-D b.e.) on protein and nucleic acid contents of different tissues of chicks born from externally treated hen's eggs were studied. Residues of 2,4-D b.e. were also determined and quantified by gas liquid chromatography (GLC). A diminished DNA content was observed in skeletal muscle and stomach, an increased one was found in cerebrum and cerebellum, whereas no variations were observed in the other analysed tissues. Protein levels were found decreased in kidney, cerebrum and heart. Besides, the GLC determinations revealed the presence of the 2,4-D b.e. in all the studied tissues finding the highest concentrations in kidney. 2,4-D did not appear to be a significant metabolite of 2,4-D b.e. in this experimental system. The dissimilar effects of 2,4-D b.e. on protein and nucleic acid contents of the studied tissues would be related to a different tissue susceptibility to the drug and/or to drug distribution.</description><subject>2,4-Dichlorophenoxyacetic Acid - analogs & derivatives</subject><subject>2,4-Dichlorophenoxyacetic Acid - analysis</subject><subject>2,4-Dichlorophenoxyacetic Acid - blood</subject><subject>2,4-Dichlorophenoxyacetic Acid - pharmacology</subject><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - embryology</subject><subject>Chick Embryo</subject><subject>DNA - analysis</subject><subject>Heart - drug effects</subject><subject>Heart - embryology</subject><subject>Kidney - drug effects</subject><subject>Kidney - embryology</subject><subject>Liver - drug effects</subject><subject>Liver - embryology</subject><subject>Proteins - analysis</subject><subject>RNA - analysis</subject><subject>Stomach - drug effects</subject><subject>Stomach - embryology</subject><issn>0148-0545</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkD1PwzAYhD2ASin8AAYkT0wE7Dhp7BFVfEkVLDBH_njdGBI72I5EN346QXQ66XR6dHcIXVBywygRt4RWnNQVb4ggVSkEPULLP6-YzfoEnab0QQgtRc0WaFFWFaeULdHPy6R7cBpL7QzWwWfwGUtvcITkzATYQIY4OC-zCx47j7NLaYKEg8W6c_ozYRWixzaGAZfXVWGc7voQw9iBD997qSHPfDXlfY8hzTCcI8gMBsNul87QsZV9gvODrtD7w_3b5qnYvj4-b-62xUgZz4UyNeVWrpXSRgBvQFDQVutaSZCaNWCAU6640YJKaSRT1bzVGkvtWjZrxlbo6p87xvA118_t4JKGvpcewpTapuGCc9HMwctDcFIDmHaMbpBx3x4uY791wXCk</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Duffard, R O</creator><creator>Fabra de Peretti, A I</creator><creator>Castro de Cantarini, S M</creator><creator>Mori de Moro, G B</creator><creator>Argüello, J M</creator><creator>Evangelista de Duffard, A M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Nucleic acid content and residue determination in tissues of chicks born from 2,4-dichlorophenoxyacetic butyl ester treated eggs</title><author>Duffard, R O ; Fabra de Peretti, A I ; Castro de Cantarini, S M ; Mori de Moro, G B ; Argüello, J M ; Evangelista de Duffard, A M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-bd518fa6bbcd9e87e91ecfcc5baeac37ede818b8dc91aada3b4129fdf1f6a7633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>2,4-Dichlorophenoxyacetic Acid - analogs & derivatives</topic><topic>2,4-Dichlorophenoxyacetic Acid - analysis</topic><topic>2,4-Dichlorophenoxyacetic Acid - blood</topic><topic>2,4-Dichlorophenoxyacetic Acid - pharmacology</topic><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - embryology</topic><topic>Chick Embryo</topic><topic>DNA - analysis</topic><topic>Heart - drug effects</topic><topic>Heart - embryology</topic><topic>Kidney - drug effects</topic><topic>Kidney - embryology</topic><topic>Liver - drug effects</topic><topic>Liver - embryology</topic><topic>Proteins - analysis</topic><topic>RNA - analysis</topic><topic>Stomach - drug effects</topic><topic>Stomach - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duffard, R O</creatorcontrib><creatorcontrib>Fabra de Peretti, A I</creatorcontrib><creatorcontrib>Castro de Cantarini, S M</creatorcontrib><creatorcontrib>Mori de Moro, G B</creatorcontrib><creatorcontrib>Argüello, J M</creatorcontrib><creatorcontrib>Evangelista de Duffard, A M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duffard, R O</au><au>Fabra de Peretti, A I</au><au>Castro de Cantarini, S M</au><au>Mori de Moro, G B</au><au>Argüello, J M</au><au>Evangelista de Duffard, A M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleic acid content and residue determination in tissues of chicks born from 2,4-dichlorophenoxyacetic butyl ester treated eggs</atitle><jtitle>Drug and chemical toxicology (New York, N.Y. 1978)</jtitle><addtitle>Drug Chem Toxicol</addtitle><date>1987</date><risdate>1987</risdate><volume>10</volume><issue>3-4</issue><spage>339</spage><epage>355</epage><pages>339-355</pages><issn>0148-0545</issn><abstract>The effects of 2,4-dichlorophenoxyacetic butyl ester (2,4-D b.e.) on protein and nucleic acid contents of different tissues of chicks born from externally treated hen's eggs were studied. Residues of 2,4-D b.e. were also determined and quantified by gas liquid chromatography (GLC). A diminished DNA content was observed in skeletal muscle and stomach, an increased one was found in cerebrum and cerebellum, whereas no variations were observed in the other analysed tissues. Protein levels were found decreased in kidney, cerebrum and heart. Besides, the GLC determinations revealed the presence of the 2,4-D b.e. in all the studied tissues finding the highest concentrations in kidney. 2,4-D did not appear to be a significant metabolite of 2,4-D b.e. in this experimental system. The dissimilar effects of 2,4-D b.e. on protein and nucleic acid contents of the studied tissues would be related to a different tissue susceptibility to the drug and/or to drug distribution.</abstract><cop>United States</cop><pmid>2448113</pmid><doi>10.3109/01480548709042991</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-0545 |
| ispartof | Drug and chemical toxicology (New York, N.Y. 1978), 1987, Vol.10 (3-4), p.339-355 |
| issn | 0148-0545 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | 2,4-Dichlorophenoxyacetic Acid - analogs & derivatives 2,4-Dichlorophenoxyacetic Acid - analysis 2,4-Dichlorophenoxyacetic Acid - blood 2,4-Dichlorophenoxyacetic Acid - pharmacology Animals Brain - drug effects Brain - embryology Chick Embryo DNA - analysis Heart - drug effects Heart - embryology Kidney - drug effects Kidney - embryology Liver - drug effects Liver - embryology Proteins - analysis RNA - analysis Stomach - drug effects Stomach - embryology |
| title | Nucleic acid content and residue determination in tissues of chicks born from 2,4-dichlorophenoxyacetic butyl ester treated eggs |
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