Structural effects of the selective reduction of amide carbonyl groups in motilin 1-12 as determined by nuclear magnetic resonance

Motilin is a 22‐residue peptide stimulating stomach and intestinal motility. The motilin 1–12 fragment displays biological effects similar to the native peptide. Selective reduction of the amide carbonyl groups to form CH2NH analogs leads to a significant reduction in activity for the first two N‐te...

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Veröffentlicht in:	International Journal of Peptide and Protein Research 1995-12, Vol.46 (6), p.527-534
Hauptverfasser:	BOULANGER, YVAN, KHIAT, ABDESSLEM, CHEN, YANMIN, GAGNON, DIANE, POITRAS, PIERRE, ST-PIERRE, SERGE
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Animals enzymatic cleavage protection analogs Magnetic Resonance Spectroscopy molecular modeling Motilin - chemistry peptide conformation Protein Conformation Structure-Activity Relationship Swine two-dimensional NMR
Online-Zugang:	Volltext
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