Small Intestinal Permeability in Pediatric Clinical Practice
Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cowsʼ milk intolerance were shown to have an elevated urinary lactulose/mannitol...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1987-09, Vol.6 (5), p.697-701 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 701 |
|---|---|
| container_issue | 5 |
| container_start_page | 697 |
| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 6 |
| creator | Hamilton, I Hill, A Bose, B Bouchier, I A. D Forsyth, J S |
| description | Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cowsʼ milk intolerance were shown to have an elevated urinary lactulose/mannitol recovery ratio when compared with controls, children with normal jejunal biopsy, or children in whom alternative explanations for failure to thrive had been demonstrated. The abnormality in permeability ratio principally reflects a reduced urinary recovery of mannitol following oral administration. This study demonstrates that a hypertonic sugar absorption test is well tolerated even by young children, is practicable in routine clinical pediatric practice, and is capable of demonstrating abnormal intestinal function in children with small intestinal disease. |
| doi_str_mv | 10.1097/00005176-198709000-00006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77896230</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77896230</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4346-445e0f9d6de496b090eb57de302bd1394efc9a296f0ab3ae8288f7d102d240873</originalsourceid><addsrcrecordid>eNp1kU1LAzEQhoMotVZ_grAH8baar80HeJHiR6GgoJ5DNjtLo9ltTbaI_97U1t6cS5iZZyYv7yBUEHxFsJbXOEdFpCiJVhLrnJWbkjhAY1IxUXKFySEaYyplSQkRx-gkpfdMSF7hERoxQoli1RjdvHQ2hGLWD5AG39tQPEPswNY--OG78H3OG2-H6F0xDb73boNE6wbv4BQdtTYkONu9E_R2f_c6fSznTw-z6e28dJzxLIZXgFvdiAa4FnWWC3UlG2CY1g1hmkPrtKVatNjWzIKiSrWyIZg2lGMl2QRdbveu4vJznYWazicHIdgelutkpFRaUIYzqLagi8uUIrRmFX1n47ch2GyMM3_Gmb1xvyWRR893f6zrDpr94M6p3L_Y9W3KHrTR9s6nPSYrxilWGeNb7GsZBojpI6y_IJoF2DAszH9nYz9z8YPB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77896230</pqid></control><display><type>article</type><title>Small Intestinal Permeability in Pediatric Clinical Practice</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Hamilton, I ; Hill, A ; Bose, B ; Bouchier, I A. D ; Forsyth, J S</creator><creatorcontrib>Hamilton, I ; Hill, A ; Bose, B ; Bouchier, I A. D ; Forsyth, J S</creatorcontrib><description>Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cowsʼ milk intolerance were shown to have an elevated urinary lactulose/mannitol recovery ratio when compared with controls, children with normal jejunal biopsy, or children in whom alternative explanations for failure to thrive had been demonstrated. The abnormality in permeability ratio principally reflects a reduced urinary recovery of mannitol following oral administration. This study demonstrates that a hypertonic sugar absorption test is well tolerated even by young children, is practicable in routine clinical pediatric practice, and is capable of demonstrating abnormal intestinal function in children with small intestinal disease.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/00005176-198709000-00006</identifier><identifier>PMID: 3121835</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adolescent ; Biological and medical sciences ; Celiac Disease - metabolism ; Child ; Child, Preschool ; Disaccharides - metabolism ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Infant ; Intestine, Small - metabolism ; Jejunum - metabolism ; Lactose Intolerance - metabolism ; Lactulose - metabolism ; Male ; Mannitol - metabolism ; Medical sciences ; Other diseases. Semiology ; Permeability ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1987-09, Vol.6 (5), p.697-701</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-445e0f9d6de496b090eb57de302bd1394efc9a296f0ab3ae8288f7d102d240873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7534208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3121835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamilton, I</creatorcontrib><creatorcontrib>Hill, A</creatorcontrib><creatorcontrib>Bose, B</creatorcontrib><creatorcontrib>Bouchier, I A. D</creatorcontrib><creatorcontrib>Forsyth, J S</creatorcontrib><title>Small Intestinal Permeability in Pediatric Clinical Practice</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cowsʼ milk intolerance were shown to have an elevated urinary lactulose/mannitol recovery ratio when compared with controls, children with normal jejunal biopsy, or children in whom alternative explanations for failure to thrive had been demonstrated. The abnormality in permeability ratio principally reflects a reduced urinary recovery of mannitol following oral administration. This study demonstrates that a hypertonic sugar absorption test is well tolerated even by young children, is practicable in routine clinical pediatric practice, and is capable of demonstrating abnormal intestinal function in children with small intestinal disease.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disaccharides - metabolism</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestine, Small - metabolism</subject><subject>Jejunum - metabolism</subject><subject>Lactose Intolerance - metabolism</subject><subject>Lactulose - metabolism</subject><subject>Male</subject><subject>Mannitol - metabolism</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Permeability</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LAzEQhoMotVZ_grAH8baar80HeJHiR6GgoJ5DNjtLo9ltTbaI_97U1t6cS5iZZyYv7yBUEHxFsJbXOEdFpCiJVhLrnJWbkjhAY1IxUXKFySEaYyplSQkRx-gkpfdMSF7hERoxQoli1RjdvHQ2hGLWD5AG39tQPEPswNY--OG78H3OG2-H6F0xDb73boNE6wbv4BQdtTYkONu9E_R2f_c6fSznTw-z6e28dJzxLIZXgFvdiAa4FnWWC3UlG2CY1g1hmkPrtKVatNjWzIKiSrWyIZg2lGMl2QRdbveu4vJznYWazicHIdgelutkpFRaUIYzqLagi8uUIrRmFX1n47ch2GyMM3_Gmb1xvyWRR893f6zrDpr94M6p3L_Y9W3KHrTR9s6nPSYrxilWGeNb7GsZBojpI6y_IJoF2DAszH9nYz9z8YPB</recordid><startdate>198709</startdate><enddate>198709</enddate><creator>Hamilton, I</creator><creator>Hill, A</creator><creator>Bose, B</creator><creator>Bouchier, I A. D</creator><creator>Forsyth, J S</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198709</creationdate><title>Small Intestinal Permeability in Pediatric Clinical Practice</title><author>Hamilton, I ; Hill, A ; Bose, B ; Bouchier, I A. D ; Forsyth, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-445e0f9d6de496b090eb57de302bd1394efc9a296f0ab3ae8288f7d102d240873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Celiac Disease - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disaccharides - metabolism</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestine, Small - metabolism</topic><topic>Jejunum - metabolism</topic><topic>Lactose Intolerance - metabolism</topic><topic>Lactulose - metabolism</topic><topic>Male</topic><topic>Mannitol - metabolism</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Permeability</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamilton, I</creatorcontrib><creatorcontrib>Hill, A</creatorcontrib><creatorcontrib>Bose, B</creatorcontrib><creatorcontrib>Bouchier, I A. D</creatorcontrib><creatorcontrib>Forsyth, J S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamilton, I</au><au>Hill, A</au><au>Bose, B</au><au>Bouchier, I A. D</au><au>Forsyth, J S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small Intestinal Permeability in Pediatric Clinical Practice</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1987-09</date><risdate>1987</risdate><volume>6</volume><issue>5</issue><spage>697</spage><epage>701</epage><pages>697-701</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cowsʼ milk intolerance were shown to have an elevated urinary lactulose/mannitol recovery ratio when compared with controls, children with normal jejunal biopsy, or children in whom alternative explanations for failure to thrive had been demonstrated. The abnormality in permeability ratio principally reflects a reduced urinary recovery of mannitol following oral administration. This study demonstrates that a hypertonic sugar absorption test is well tolerated even by young children, is practicable in routine clinical pediatric practice, and is capable of demonstrating abnormal intestinal function in children with small intestinal disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>3121835</pmid><doi>10.1097/00005176-198709000-00006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 1987-09, Vol.6 (5), p.697-701 |
| issn | 0277-2116 1536-4801 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77896230 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Biological and medical sciences Celiac Disease - metabolism Child Child, Preschool Disaccharides - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen Humans Infant Intestine, Small - metabolism Jejunum - metabolism Lactose Intolerance - metabolism Lactulose - metabolism Male Mannitol - metabolism Medical sciences Other diseases. Semiology Permeability Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Small Intestinal Permeability in Pediatric Clinical Practice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T23%3A10%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Small%20Intestinal%20Permeability%20in%20Pediatric%20Clinical%20Practice&rft.jtitle=Journal%20of%20pediatric%20gastroenterology%20and%20nutrition&rft.au=Hamilton,%20I&rft.date=1987-09&rft.volume=6&rft.issue=5&rft.spage=697&rft.epage=701&rft.pages=697-701&rft.issn=0277-2116&rft.eissn=1536-4801&rft.coden=JPGND6&rft_id=info:doi/10.1097/00005176-198709000-00006&rft_dat=%3Cproquest_cross%3E77896230%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77896230&rft_id=info:pmid/3121835&rfr_iscdi=true |