Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist : effects of apparent agonist affinities

Previous work has shown that 5-hydroxytryptamine (5-HT)2A receptors can be radiolabelled with various radioligands, including partial agonists, such as [125I]-DOI and [3H]-DOB, and antagonists, such as [3H]-ketanserin and [3H]-spiperone. Because 5-HT has high affinity for the 5-HT2A receptor when di...

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Veröffentlicht in:	Biochemical pharmacology 1996-01, Vol.51 (1), p.71-76
Hauptverfasser:	SLEIGHT, A. J, STAM, N. J, MUTEL, V, VANDERHEYDEN, P. M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding, Competitive Biological and medical sciences Cell Membrane - metabolism Cell receptors Cell structures and functions DOM 2,5-Dimethoxy-4-Methylamphetamine - analogs & derivatives DOM 2,5-Dimethoxy-4-Methylamphetamine - metabolism Fundamental and applied biological sciences. Psychology Humans Ketanserin - metabolism Mice Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Radioligand Assay Receptor, Serotonin, 5-HT2A Receptors, Serotonin - metabolism Recombinant Proteins Serotonin - metabolism Serotonin Antagonists - chemistry Serotonin Receptor Agonists - chemistry
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