Developing gossypol derivatives with enhanced antitumor activity

Preclinical and clinical studies have pointed to the antitumor potential of the naturally occurring polyphenolic binaphthyl dialdehyde, gossypol, as well as its purified (-,+) enantiomers. To explore further the antitumor properties of this multifunctional agent, we synthesized several reactive deri...

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Veröffentlicht in:	Investigational new drugs 1995-01, Vol.13 (3), p.181-186
Hauptverfasser:	LIANG, X. S, ROGERS, A. J, WEBBER, C. L, ORMSBY, T. J, TIRITAN, M. E, MATLIN, S. A, BENZ, C. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Breast Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Epithelium - drug effects Female General aspects Gossypol - analogs & derivatives Gossypol - chemistry Gossypol - pharmacology Humans Medical sciences Molecular Conformation Pharmacology. Drug treatments Schiff Bases - chemical synthesis Schiff Bases - therapeutic use Tumor Cells, Cultured - drug effects
Online-Zugang:	Volltext
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