Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis wer...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1995/12/15, Vol.18(12), pp.1714-1717 |
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| creator | KAWASAKI, Koichi NAMIKAWA, Machiko MIZUTA, Toyohiko INOUE, Sachie MAEDA, Mitsuko KAKIUCHI, Masa IZUNO, Yasuhiro YAMAMOTO, Susumu TSUTSUMI, Yasuo NAKAGAWA, Shinsaku MAYUMI, Tadanori |
| description | Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect. |
| doi_str_mv | 10.1248/bpb.18.1714 |
| format | Article |
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XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>KAWASAKI, Koichi ; NAMIKAWA, Machiko ; MIZUTA, Toyohiko ; INOUE, Sachie ; MAEDA, Mitsuko ; KAKIUCHI, Masa ; IZUNO, Yasuhiro ; YAMAMOTO, Susumu ; TSUTSUMI, Yasuo ; NAKAGAWA, Shinsaku ; MAYUMI, Tadanori</creator><creatorcontrib>KAWASAKI, Koichi ; NAMIKAWA, Machiko ; MIZUTA, Toyohiko ; INOUE, Sachie ; MAEDA, Mitsuko ; KAKIUCHI, Masa ; IZUNO, Yasuhiro ; YAMAMOTO, Susumu ; TSUTSUMI, Yasuo ; NAKAGAWA, Shinsaku ; MAYUMI, Tadanori</creatorcontrib><description>Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.18.1714</identifier><identifier>PMID: 8787794</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Amino Acid Sequence ; Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; General aspects ; hybrid ; laminin ; Laminin - analogs & derivatives ; Laminin - pharmacology ; Medical sciences ; metastasis inhibitor ; Mice ; Molecular Sequence Data ; Neoplasm Metastasis - prevention & control ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - pathology ; Oligopeptides - pharmacology ; Pharmacology. Drug treatments ; poly (ethylene glycol) ; poly (ethylene glycol) hybrid ; Polyethylene Glycols - pharmacology ; polymer hybrid</subject><ispartof>Biological and Pharmaceutical Bulletin, 1995/12/15, Vol.18(12), pp.1714-1717</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4224-d8e2417f128568c0c482c63646f8ebe90f7167eefaf48aa3c4dec93e2dd2438d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2996117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8787794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAWASAKI, Koichi</creatorcontrib><creatorcontrib>NAMIKAWA, Machiko</creatorcontrib><creatorcontrib>MIZUTA, Toyohiko</creatorcontrib><creatorcontrib>INOUE, Sachie</creatorcontrib><creatorcontrib>MAEDA, Mitsuko</creatorcontrib><creatorcontrib>KAKIUCHI, Masa</creatorcontrib><creatorcontrib>IZUNO, Yasuhiro</creatorcontrib><creatorcontrib>YAMAMOTO, Susumu</creatorcontrib><creatorcontrib>TSUTSUMI, Yasuo</creatorcontrib><creatorcontrib>NAKAGAWA, Shinsaku</creatorcontrib><creatorcontrib>MAYUMI, Tadanori</creatorcontrib><title>Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>General aspects</subject><subject>hybrid</subject><subject>laminin</subject><subject>Laminin - analogs & derivatives</subject><subject>Laminin - pharmacology</subject><subject>Medical sciences</subject><subject>metastasis inhibitor</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Metastasis - prevention & control</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Oligopeptides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>poly (ethylene glycol)</subject><subject>poly (ethylene glycol) hybrid</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>polymer hybrid</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVGL1DAUhYMo67j65LMQUESR1iRNm-RxWGZ3B0ZcZJV9K2l662TIpDXpgP0R_mczzmwfhHDzcD7OSe5B6DUlOWVcfm6GJqcyp4LyJ2hBCy6yktHyKVoQRWVW0VI-Ry9i3BFCBGHFBbqQQgqh-AL9We6t7_HS2DZi7Vt8B8NoW4g5fnj4sc7xRifA-uwbOD3CrOO73k34w2rcTg484Bs3md59xLdTEx6t7rdgA177rW3s2IcJr7oOzIh7j1e_Bwh2D37UDn-BUcd0bHyJnnXaRXh1vi_R9-vV_dVttvl6s75abjLDGeNZK4FxKjrKZFlJQwyXzFRFxatOQgOKdIJWAqDTHZdaF4a3YFQBrG0ZL2RbXKL3J98h9L8OEMd6b6MB57SH_hBrIaSinFcJfPsfuOsPwae31UlXtGKClIn6dKJM6GMM0NVD-pwOU01JfayoThXVVNbHihL95ux5aPbQzuy5k6S_O-s6Gu26oL2xccaYUhWlImHXJ2yXdvcTZl2H0RoHx0iqVPEvlj3OlD8DZqtDDb74C9UYsU8</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>KAWASAKI, Koichi</creator><creator>NAMIKAWA, Machiko</creator><creator>MIZUTA, Toyohiko</creator><creator>INOUE, Sachie</creator><creator>MAEDA, Mitsuko</creator><creator>KAKIUCHI, Masa</creator><creator>IZUNO, Yasuhiro</creator><creator>YAMAMOTO, Susumu</creator><creator>TSUTSUMI, Yasuo</creator><creator>NAKAGAWA, Shinsaku</creator><creator>MAYUMI, Tadanori</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199512</creationdate><title>Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis</title><author>KAWASAKI, Koichi ; NAMIKAWA, Machiko ; MIZUTA, Toyohiko ; INOUE, Sachie ; MAEDA, Mitsuko ; KAKIUCHI, Masa ; IZUNO, Yasuhiro ; YAMAMOTO, Susumu ; TSUTSUMI, Yasuo ; NAKAGAWA, Shinsaku ; MAYUMI, Tadanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4224-d8e2417f128568c0c482c63646f8ebe90f7167eefaf48aa3c4dec93e2dd2438d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>General aspects</topic><topic>hybrid</topic><topic>laminin</topic><topic>Laminin - analogs & derivatives</topic><topic>Laminin - pharmacology</topic><topic>Medical sciences</topic><topic>metastasis inhibitor</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Metastasis - prevention & control</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Oligopeptides - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>poly (ethylene glycol)</topic><topic>poly (ethylene glycol) hybrid</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>polymer hybrid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWASAKI, Koichi</creatorcontrib><creatorcontrib>NAMIKAWA, Machiko</creatorcontrib><creatorcontrib>MIZUTA, Toyohiko</creatorcontrib><creatorcontrib>INOUE, Sachie</creatorcontrib><creatorcontrib>MAEDA, Mitsuko</creatorcontrib><creatorcontrib>KAKIUCHI, Masa</creatorcontrib><creatorcontrib>IZUNO, Yasuhiro</creatorcontrib><creatorcontrib>YAMAMOTO, Susumu</creatorcontrib><creatorcontrib>TSUTSUMI, Yasuo</creatorcontrib><creatorcontrib>NAKAGAWA, Shinsaku</creatorcontrib><creatorcontrib>MAYUMI, Tadanori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWASAKI, Koichi</au><au>NAMIKAWA, Machiko</au><au>MIZUTA, Toyohiko</au><au>INOUE, Sachie</au><au>MAEDA, Mitsuko</au><au>KAKIUCHI, Masa</au><au>IZUNO, Yasuhiro</au><au>YAMAMOTO, Susumu</au><au>TSUTSUMI, Yasuo</au><au>NAKAGAWA, Shinsaku</au><au>MAYUMI, Tadanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1995-12</date><risdate>1995</risdate><volume>18</volume><issue>12</issue><spage>1714</spage><epage>1717</epage><pages>1714-1717</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Laminin-related peptide poly (ethylene glycol) hybrid, Tyr-Ile-Gly-Ser-Arg-aminopoly (ethylene glycol) was prepared by the solution method and carboxylated poly (ethylene glycol)-Tyr-Ile-Gly-Ser-Arg was prepared by the solid phase method. Their inhibitory effects on experimental tumor metastasis were examined in mice. The inhibitory effect of Tyr-Ile-Gly-Ser-Arg was significantly potentiated by hybrid formation with poly (ethylene glycol) either at amino- or carboxyl terminals of the peptide. Of the hybrids, Tyr-Ile-Gly-Ser-Arg-amino (polyethylene glycol) #6000 hybrid exhibited about 10 times more potent anti-metastatic effect than the peptide itself. The inhibitory effect of a mixture of the carboxylated poly (ethylene glycol) hybrid and Arg-Gly-Asp-aminopoly (ethylene glycol) hybrid also exhibited an inhibitory effect.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8787794</pmid><doi>10.1248/bpb.18.1714</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1995/12/15, Vol.18(12), pp.1714-1717 |
| issn | 0918-6158 1347-5215 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences General aspects hybrid laminin Laminin - analogs & derivatives Laminin - pharmacology Medical sciences metastasis inhibitor Mice Molecular Sequence Data Neoplasm Metastasis - prevention & control Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Oligopeptides - pharmacology Pharmacology. Drug treatments poly (ethylene glycol) poly (ethylene glycol) hybrid Polyethylene Glycols - pharmacology polymer hybrid |
| title | Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis |
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