Channel opening of .gamma.-aminobutyric acid receptor from rat brain: molecular mechanisms of the receptor responses

The function of gamma-aminobutyric acid (GABA) receptors, which mediate transmembrane chloride flux, can be studied by use of 36Cl- isotope tracer with membrane from mammalian brain by quench-flow technique, with reaction times that allow resolution of the receptor desensitization rates from the ion...

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Veröffentlicht in:	Biochemistry (Easton) 1987-12, Vol.26 (24), p.7562-7570
Hauptverfasser:	Cash, Derek J, Subbarao, Katragadda
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ALKALINE EARTH METAL COMPOUNDS AMINO ACIDS AMINOBUTYRIC ACID ANIMALS AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Bicuculline - pharmacology BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY BRAIN CALCIUM CHLORIDES CALCIUM COMPOUNDS CALCIUM HALIDES CARBOXYLIC ACIDS CELL CONSTITUENTS Cell Membrane - metabolism CELL MEMBRANES Cell receptors Cell structures and functions CENTRAL NERVOUS SYSTEM Cerebral Cortex - metabolism CHLORIDES Chlorides - metabolism CHLORINE 36 CHLORINE COMPOUNDS CHLORINE ISOTOPES DOSE-RESPONSE RELATIONSHIPS DRUGS ELECTRON CAPTURE RADIOISOTOPES Fundamental and applied biological sciences. Psychology gamma -aminobutyric acid gamma-Aminobutyric Acid - pharmacology HALIDES HALOGEN COMPOUNDS Ion Channels - drug effects Ion Channels - metabolism ions ISOTOPE APPLICATIONS ISOTOPES KINETICS LIGHT NUCLEI MAGNESIUM CHLORIDES MAGNESIUM COMPOUNDS Male MAMMALS MEMBRANE PROTEINS MEMBRANE TRANSPORT MEMBRANES Models, Theoretical Molecular and cellular biology NERVOUS SYSTEM NEUROREGULATORS NUCLEI ODD-ODD NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PROTEINS RADIOISOTOPES RATS Rats, Inbred Strains REACTION KINETICS RECEPTORS Receptors, GABA-A - metabolism RODENTS SENSITIVITY TRACER TECHNIQUES VERTEBRATES YEARS LIVING RADIOISOTOPES
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