Spectroscopic diagnosis of bladder cancer with elastic light scattering
Background and Objectives: Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics. The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer. Study Design/Materials and Methods: In vivo measure...
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| Veröffentlicht in: | Lasers in surgery and medicine 1995, Vol.17 (4), p.350-357 |
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| creator | Mourant, Judith R. Bigio, Irving J. Boyer, James Conn, Richard L. Johnson, Tamara Shimada, Tsutomu |
| description | Background and Objectives: Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics. The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer. Study Design/Materials and Methods: In vivo measurements on 10 patients with suspected bladder cancer were made with the optical biopsy system (OBS) developed at Los Alamos National Laboratory. Elastic‐scatter spectra over the wavelength range 250–800 nm were obtained using a fiber‐optic probe through one of the lumens of a urological cystoscope. Measurements were made on putatively normal areas and areas of uncertain abnormality, as well as those suspected to be cancerous. After measurements were made with the OBS, biopsy samples were taken at the measurement sites. Comparisons of the histopathology and the optical spectra were then made.
Results and Conclusions: A diagnostic algorithm for distinguishing malignant from nonmalignant tissue based on the values of the slopes over the wavelength range 330–370 nm has a sensitivity of 100% and specificity of 97% for the limited number of patients in this Study. |
| doi_str_mv | 10.1002/lsm.1900170403 |
| format | Article |
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Results and Conclusions: A diagnostic algorithm for distinguishing malignant from nonmalignant tissue based on the values of the slopes over the wavelength range 330–370 nm has a sensitivity of 100% and specificity of 97% for the limited number of patients in this Study.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.1900170403</identifier><identifier>PMID: 8684237</identifier><identifier>CODEN: LSMEDI</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Absorption ; Biological and medical sciences ; Biopsy - methods ; cancer detection ; Carcinoma in Situ - diagnosis ; Carcinoma in Situ - pathology ; Carcinoma, Transitional Cell - diagnosis ; Carcinoma, Transitional Cell - pathology ; Cystoscopes ; Epithelium - pathology ; Equipment Design ; Fiber Optic Technology - instrumentation ; Hemoglobins - radiation effects ; Humans ; Hyperplasia ; Light ; Medical sciences ; Nephrology. Urinary tract diseases ; noninvasive diagnostics ; optical biopsy ; Optical Fibers ; optical tissue diagnostics ; Scattering, Radiation ; Spectrometry, Fluorescence - methods ; spectroscopy ; Spectrum Analysis - instrumentation ; Spectrum Analysis - methods ; Tumors of the urinary system ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - pathology ; Urinary tract. Prostate gland ; Xenon</subject><ispartof>Lasers in surgery and medicine, 1995, Vol.17 (4), p.350-357</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4073-a80f85b3b97b55c59631d6c2dc359221756fc99394f0257d4346d8c1fd6809e23</citedby><cites>FETCH-LOGICAL-c4073-a80f85b3b97b55c59631d6c2dc359221756fc99394f0257d4346d8c1fd6809e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.1900170403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.1900170403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,4025,27925,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2936332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8684237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mourant, Judith R.</creatorcontrib><creatorcontrib>Bigio, Irving J.</creatorcontrib><creatorcontrib>Boyer, James</creatorcontrib><creatorcontrib>Conn, Richard L.</creatorcontrib><creatorcontrib>Johnson, Tamara</creatorcontrib><creatorcontrib>Shimada, Tsutomu</creatorcontrib><title>Spectroscopic diagnosis of bladder cancer with elastic light scattering</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objectives: Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics. The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer. Study Design/Materials and Methods: In vivo measurements on 10 patients with suspected bladder cancer were made with the optical biopsy system (OBS) developed at Los Alamos National Laboratory. Elastic‐scatter spectra over the wavelength range 250–800 nm were obtained using a fiber‐optic probe through one of the lumens of a urological cystoscope. Measurements were made on putatively normal areas and areas of uncertain abnormality, as well as those suspected to be cancerous. After measurements were made with the OBS, biopsy samples were taken at the measurement sites. Comparisons of the histopathology and the optical spectra were then made.
Results and Conclusions: A diagnostic algorithm for distinguishing malignant from nonmalignant tissue based on the values of the slopes over the wavelength range 330–370 nm has a sensitivity of 100% and specificity of 97% for the limited number of patients in this Study.</description><subject>Absorption</subject><subject>Biological and medical sciences</subject><subject>Biopsy - methods</subject><subject>cancer detection</subject><subject>Carcinoma in Situ - diagnosis</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Transitional Cell - diagnosis</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Cystoscopes</subject><subject>Epithelium - pathology</subject><subject>Equipment Design</subject><subject>Fiber Optic Technology - instrumentation</subject><subject>Hemoglobins - radiation effects</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>noninvasive diagnostics</subject><subject>optical biopsy</subject><subject>Optical Fibers</subject><subject>optical tissue diagnostics</subject><subject>Scattering, Radiation</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>spectroscopy</subject><subject>Spectrum Analysis - instrumentation</subject><subject>Spectrum Analysis - methods</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary tract. Prostate gland</subject><subject>Xenon</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2KKqS0194q7QH1tunYXn8dS0QDUoBDWvVoeW1vMHWywd4I-Pd1lCiIE6exNM-M530Q-ophggHIj5hXE6wAsIAG6Ac0xqB4rTDgEzQGXN4SFDlFn3J-AABKQIzQSHLZECrGaLbYeDukPtt-E2zlglmu-xxy1XdVG41zPlXWrG0pT2G4r3w0eShgDMv7ocrWDINPYb38jD52Jmb_5VDP0J9fl7-nV_X8bnY9_TmvbQOC1kZCJ1lLWyVaxixTnGLHLXGWMkUIFox3Vimqmg4IE66hDXfS4s7xEsMTeoa-7_duUv-49XnQq5Ctj9Gsfb_NWghZZIAs4GQP2hIuJ9_pTQork140Br0zp4s5_WquDHw7bN62K--O-EFV6Z8f-qbEjl0qVkI-YkRRTunuQLXHnkL0L-98queLmzcn1PvZkAf_fJw16Z_mggqm_97O9MUCmLrBUhP6H6UWlLs</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Mourant, Judith R.</creator><creator>Bigio, Irving J.</creator><creator>Boyer, James</creator><creator>Conn, Richard L.</creator><creator>Johnson, Tamara</creator><creator>Shimada, Tsutomu</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Spectroscopic diagnosis of bladder cancer with elastic light scattering</title><author>Mourant, Judith R. ; Bigio, Irving J. ; Boyer, James ; Conn, Richard L. ; Johnson, Tamara ; Shimada, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4073-a80f85b3b97b55c59631d6c2dc359221756fc99394f0257d4346d8c1fd6809e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Absorption</topic><topic>Biological and medical sciences</topic><topic>Biopsy - methods</topic><topic>cancer detection</topic><topic>Carcinoma in Situ - diagnosis</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Transitional Cell - diagnosis</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Cystoscopes</topic><topic>Epithelium - pathology</topic><topic>Equipment Design</topic><topic>Fiber Optic Technology - instrumentation</topic><topic>Hemoglobins - radiation effects</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>noninvasive diagnostics</topic><topic>optical biopsy</topic><topic>Optical Fibers</topic><topic>optical tissue diagnostics</topic><topic>Scattering, Radiation</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>spectroscopy</topic><topic>Spectrum Analysis - instrumentation</topic><topic>Spectrum Analysis - methods</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary tract. Prostate gland</topic><topic>Xenon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mourant, Judith R.</creatorcontrib><creatorcontrib>Bigio, Irving J.</creatorcontrib><creatorcontrib>Boyer, James</creatorcontrib><creatorcontrib>Conn, Richard L.</creatorcontrib><creatorcontrib>Johnson, Tamara</creatorcontrib><creatorcontrib>Shimada, Tsutomu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mourant, Judith R.</au><au>Bigio, Irving J.</au><au>Boyer, James</au><au>Conn, Richard L.</au><au>Johnson, Tamara</au><au>Shimada, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectroscopic diagnosis of bladder cancer with elastic light scattering</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>1995</date><risdate>1995</risdate><volume>17</volume><issue>4</issue><spage>350</spage><epage>357</epage><pages>350-357</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><coden>LSMEDI</coden><abstract>Background and Objectives: Recently, significant progress has been made toward the development of optical, noninvasive medical diagnostics. The goal of this study was to evaluate elastic scatter measurements as a tool for diagnosing bladder cancer. Study Design/Materials and Methods: In vivo measurements on 10 patients with suspected bladder cancer were made with the optical biopsy system (OBS) developed at Los Alamos National Laboratory. Elastic‐scatter spectra over the wavelength range 250–800 nm were obtained using a fiber‐optic probe through one of the lumens of a urological cystoscope. Measurements were made on putatively normal areas and areas of uncertain abnormality, as well as those suspected to be cancerous. After measurements were made with the OBS, biopsy samples were taken at the measurement sites. Comparisons of the histopathology and the optical spectra were then made.
Results and Conclusions: A diagnostic algorithm for distinguishing malignant from nonmalignant tissue based on the values of the slopes over the wavelength range 330–370 nm has a sensitivity of 100% and specificity of 97% for the limited number of patients in this Study.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>8684237</pmid><doi>10.1002/lsm.1900170403</doi><tpages>8</tpages></addata></record> |
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| ispartof | Lasers in surgery and medicine, 1995, Vol.17 (4), p.350-357 |
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| subjects | Absorption Biological and medical sciences Biopsy - methods cancer detection Carcinoma in Situ - diagnosis Carcinoma in Situ - pathology Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - pathology Cystoscopes Epithelium - pathology Equipment Design Fiber Optic Technology - instrumentation Hemoglobins - radiation effects Humans Hyperplasia Light Medical sciences Nephrology. Urinary tract diseases noninvasive diagnostics optical biopsy Optical Fibers optical tissue diagnostics Scattering, Radiation Spectrometry, Fluorescence - methods spectroscopy Spectrum Analysis - instrumentation Spectrum Analysis - methods Tumors of the urinary system Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland Xenon |
| title | Spectroscopic diagnosis of bladder cancer with elastic light scattering |
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