Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice
The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice e...
Gespeichert in:
| Veröffentlicht in: | Pain (Amsterdam) 1995-12, Vol.63 (3), p.321-326 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 326 |
|---|---|
| container_issue | 3 |
| container_start_page | 321 |
| container_title | Pain (Amsterdam) |
| container_volume | 63 |
| creator | Sternberg, Wendy F. Mogil, Jeffrey S. Kest, Benjamin Page, Gayle G. Leong, Yet Yam, Ving Liebeskind, John C. |
| description | The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny. |
| doi_str_mv | 10.1016/0304-3959(95)00059-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77888925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0304395995000593</els_id><sourcerecordid>77888925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4026-414ad4c84f59b30d9d25772ed09a78a9f4f847d430786deda12fd45222efa8ed3</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo6zj6DxRyEj1E89mdXIRl8QsWveg5ZJNqJ5pJxqTbcf-9aWdYb56KKt73peophJ4y-opRNrymgkoijDIvjHpJKVWGiHtow_TIyTBwcR9t7iQP0aPWvncR59xcoAs9MqME36D6CUp2s0t4hjaXNkMtGTD8PpS2VMAxT2mB7KHhDEstfgf72OZ6i8uEc8mkHGKJAbdj3OM-h9ZIzGHxELDLLn2DFl1PwS4sacb76OExejC51ODJuW7R13dvv1x9INef33-8urwmXlI-EMmkC9JrOSlzI2gwgatx5BCocaN2ZpKTlmOQgo56CBAc41OQqh8Ik9MQxBY9P-Ueavm59Ots39xDSi5DWZodR6214aoL5Unoa2mtwmQPNe5dvbWM2hW1XTnalaM1yv5FbUW3PTvnLzd7CHemM9t_sceSOtb2Iy1HqHYHLs27NYUOwgyEGaMY7x05jbbozckGnc2v2B3Nx_UDIVbwsw0l_n-vP1UDn-c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77888925</pqid></control><display><type>article</type><title>Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Sternberg, Wendy F. ; Mogil, Jeffrey S. ; Kest, Benjamin ; Page, Gayle G. ; Leong, Yet ; Yam, Ving ; Liebeskind, John C.</creator><creatorcontrib>Sternberg, Wendy F. ; Mogil, Jeffrey S. ; Kest, Benjamin ; Page, Gayle G. ; Leong, Yet ; Yam, Ving ; Liebeskind, John C.</creatorcontrib><description>The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(95)00059-3</identifier><identifier>PMID: 8719532</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Analgesia ; Animals ; Animals, Newborn ; Body Weight - drug effects ; Body Weight - physiology ; Brain - embryology ; Dizocilpine ; Dizocilpine Maleate - pharmacology ; Estrogen ; Estrogens - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Female ; Male ; Mice ; N-methyl- d-aspartic acid ; Orchiectomy ; Pain Measurement - drug effects ; Pregnancy ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - drug effects ; Receptors, N-Methyl-D-Aspartate - physiology ; Sex Characteristics ; Stress, Psychological - physiopathology ; Swim stress-induced analgesia ; Swimming ; Testosterone ; Testosterone - pharmacology</subject><ispartof>Pain (Amsterdam), 1995-12, Vol.63 (3), p.321-326</ispartof><rights>1995 Elsevier Science B.V. All rights reserved</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4026-414ad4c84f59b30d9d25772ed09a78a9f4f847d430786deda12fd45222efa8ed3</citedby><cites>FETCH-LOGICAL-c4026-414ad4c84f59b30d9d25772ed09a78a9f4f847d430786deda12fd45222efa8ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304395995000593$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8719532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sternberg, Wendy F.</creatorcontrib><creatorcontrib>Mogil, Jeffrey S.</creatorcontrib><creatorcontrib>Kest, Benjamin</creatorcontrib><creatorcontrib>Page, Gayle G.</creatorcontrib><creatorcontrib>Leong, Yet</creatorcontrib><creatorcontrib>Yam, Ving</creatorcontrib><creatorcontrib>Liebeskind, John C.</creatorcontrib><title>Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Brain - embryology</subject><subject>Dizocilpine</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Estrogen</subject><subject>Estrogens - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Female</subject><subject>Male</subject><subject>Mice</subject><subject>N-methyl- d-aspartic acid</subject><subject>Orchiectomy</subject><subject>Pain Measurement - drug effects</subject><subject>Pregnancy</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Sex Characteristics</subject><subject>Stress, Psychological - physiopathology</subject><subject>Swim stress-induced analgesia</subject><subject>Swimming</subject><subject>Testosterone</subject><subject>Testosterone - pharmacology</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo6zj6DxRyEj1E89mdXIRl8QsWveg5ZJNqJ5pJxqTbcf-9aWdYb56KKt73peophJ4y-opRNrymgkoijDIvjHpJKVWGiHtow_TIyTBwcR9t7iQP0aPWvncR59xcoAs9MqME36D6CUp2s0t4hjaXNkMtGTD8PpS2VMAxT2mB7KHhDEstfgf72OZ6i8uEc8mkHGKJAbdj3OM-h9ZIzGHxELDLLn2DFl1PwS4sacb76OExejC51ODJuW7R13dvv1x9INef33-8urwmXlI-EMmkC9JrOSlzI2gwgatx5BCocaN2ZpKTlmOQgo56CBAc41OQqh8Ik9MQxBY9P-Ueavm59Ots39xDSi5DWZodR6214aoL5Unoa2mtwmQPNe5dvbWM2hW1XTnalaM1yv5FbUW3PTvnLzd7CHemM9t_sceSOtb2Iy1HqHYHLs27NYUOwgyEGaMY7x05jbbozckGnc2v2B3Nx_UDIVbwsw0l_n-vP1UDn-c</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>Sternberg, Wendy F.</creator><creator>Mogil, Jeffrey S.</creator><creator>Kest, Benjamin</creator><creator>Page, Gayle G.</creator><creator>Leong, Yet</creator><creator>Yam, Ving</creator><creator>Liebeskind, John C.</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951201</creationdate><title>Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice</title><author>Sternberg, Wendy F. ; Mogil, Jeffrey S. ; Kest, Benjamin ; Page, Gayle G. ; Leong, Yet ; Yam, Ving ; Liebeskind, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4026-414ad4c84f59b30d9d25772ed09a78a9f4f847d430786deda12fd45222efa8ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - physiology</topic><topic>Brain - embryology</topic><topic>Dizocilpine</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Estrogen</topic><topic>Estrogens - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Female</topic><topic>Male</topic><topic>Mice</topic><topic>N-methyl- d-aspartic acid</topic><topic>Orchiectomy</topic><topic>Pain Measurement - drug effects</topic><topic>Pregnancy</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Sex Characteristics</topic><topic>Stress, Psychological - physiopathology</topic><topic>Swim stress-induced analgesia</topic><topic>Swimming</topic><topic>Testosterone</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sternberg, Wendy F.</creatorcontrib><creatorcontrib>Mogil, Jeffrey S.</creatorcontrib><creatorcontrib>Kest, Benjamin</creatorcontrib><creatorcontrib>Page, Gayle G.</creatorcontrib><creatorcontrib>Leong, Yet</creatorcontrib><creatorcontrib>Yam, Ving</creatorcontrib><creatorcontrib>Liebeskind, John C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sternberg, Wendy F.</au><au>Mogil, Jeffrey S.</au><au>Kest, Benjamin</au><au>Page, Gayle G.</au><au>Leong, Yet</au><au>Yam, Ving</au><au>Liebeskind, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>63</volume><issue>3</issue><spage>321</spage><epage>326</epage><pages>321-326</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><abstract>The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>8719532</pmid><doi>10.1016/0304-3959(95)00059-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3959 |
| ispartof | Pain (Amsterdam), 1995-12, Vol.63 (3), p.321-326 |
| issn | 0304-3959 1872-6623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77888925 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analgesia Animals Animals, Newborn Body Weight - drug effects Body Weight - physiology Brain - embryology Dizocilpine Dizocilpine Maleate - pharmacology Estrogen Estrogens - pharmacology Excitatory Amino Acid Antagonists - pharmacology Female Male Mice N-methyl- d-aspartic acid Orchiectomy Pain Measurement - drug effects Pregnancy Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Sex Characteristics Stress, Psychological - physiopathology Swim stress-induced analgesia Swimming Testosterone Testosterone - pharmacology |
| title | Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T13%3A15%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neonatal%20testosterone%20exposure%20influences%20neurochemistry%20of%20non-opioid%20swim%20stress-induced%20analgesia%20in%20adult%20mice&rft.jtitle=Pain%20(Amsterdam)&rft.au=Sternberg,%20Wendy%20F.&rft.date=1995-12-01&rft.volume=63&rft.issue=3&rft.spage=321&rft.epage=326&rft.pages=321-326&rft.issn=0304-3959&rft.eissn=1872-6623&rft_id=info:doi/10.1016/0304-3959(95)00059-3&rft_dat=%3Cproquest_cross%3E77888925%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77888925&rft_id=info:pmid/8719532&rft_els_id=0304395995000593&rfr_iscdi=true |