Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from Subsaharan Africa

Resistance of Plasmodium falciparum to many therapeutic agents is an increasing problem in most endemic areas. The role of the mdr-like gene products of P. falciparum in resistance to quinoline-containing compounds is not clear. The purpose of this study was to further examine the role of pfmdr1 in...

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Veröffentlicht in:	Molecular and biochemical parasitology 1995-11, Vol.74 (2), p.157-166
Hauptverfasser:	Basco, Leonardo K., Bras, Jacques Le, Rhoades, Zane, Wilson, Craig M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa South of the Sahara Alleles Animals Antimalarials - pharmacology Base Sequence Chloroquine Chloroquine - pharmacology Codon - genetics DNA Fingerprinting DNA, Protozoan - genetics DNA, Protozoan - isolation & purification Drug resistance Drug Resistance, Multiple - genetics Genes, Protozoan Genetic Variation Humans Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Mefloquine Mefloquine - pharmacology Multiple drug resistant Phenotype Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - isolation & purification
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