Isolation and characterization of a protective antigen for adjuvant- free immunization against Schistosoma mansoni

A single, 68,000 m.w. glycoprotein antigen from adult Schistosoma mansoni was purified by immunoaffinity chromatography with the use of a newly developed, protective, anti-schistosome murine monoclonal antibody. Immunization with two doses of 0.5 microgram or 1 microgram of purified antigen, without...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-12, Vol.139 (12), p.4218-4224
Hauptverfasser:	King, CH, Lett, RR, Nanduri, J, el Ibiary, S, Peters, PA, Olds, GR, Mahmoud, AA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Helminth - immunology Antibodies, Monoclonal - immunology Antigens, Helminth - immunology Antigens, Helminth - isolation & purification Applied sciences Chromatography, Affinity Exact sciences and technology Female Glycoproteins - immunology Glycoproteins - isolation & purification Immunization Immunization, Passive Mice Mice, Inbred BALB C Other techniques and industries Schistosoma mansoni Schistosoma mansoni - growth & development Schistosoma mansoni - immunology Schistosomiasis mansoni - prevention & control
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