Depletion of cytosolic GSH decreases the ATP levels and viability of synaptosomes from aged mice but not from young mice

The effect of glutathione depletion on the viability of freshly isolated synaptosomes from whole brain was investigated in young and aged mice. Aging did not influence the GSH and ATP levels and the viability of these synaptosomes. However depletion of glutathione caused by the cytosolic glutathione...

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Veröffentlicht in:	Mechanisms of ageing and development 1995-09, Vol.84 (1), p.77-81
Hauptverfasser:	Martínez, Marcos, Ferrándiz, Maria Luisa, Díez, Araceli, Miquel, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aging - metabolism Aging - pathology Animals ATP Biological and medical sciences Brain ageing Cytosol - metabolism Development. Senescence. Regeneration. Transplantation Energy Metabolism - physiology Ethacrynic Acid - pharmacology Female Fundamental and applied biological sciences. Psychology Glutathione Glutathione - antagonists & inhibitors Glutathione - metabolism Mice Mitochondria Mitochondria - drug effects Random Allocation Synaptosomes Synaptosomes - physiology Vertebrates: nervous system and sense organs Viability
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