Studies on the metabolic fate of valproic acid in the rat using stable isotope techniques

1. The metabolic fate of two specifically deuterated analogues of valproic acid (VPA), [2-2H1]VPA and [3,3-2H2]VPA, was studied in the rat following i.p. injection. 2. A total of 11 urinary metabolites of each labelled substrate were detected by g.l.c.-mass spectrometry. Those metabolites which resu...

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Veröffentlicht in:	Xenobiotica 1987, Vol.17 (10), p.1147-1157
Hauptverfasser:	Rettenmeier, A. W., Gordon, W. P., Barnes, H., Baillie, T. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Biotransformation Gas Chromatography-Mass Spectrometry Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Valproic Acid - metabolism
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