The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm
We have studied the efficacy of clonidine hydrochloride administered transdermally once a week for 9 to 15 weeks in 12 patients with mild to moderate hypertension. Clonidine reduced both supine and standing blood pressures on average, but only 8 subjects were responders, i.e. had a decrease in supin...
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| Veröffentlicht in: | European journal of clinical pharmacology 1987-01, Vol.33 (2), p.111-114 |
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| container_end_page | 114 |
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| container_title | European journal of clinical pharmacology |
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| creator | ACHIMASTOS, A GIRERD, X SIMON, A. C PITHOIS-MERLI, I LEVENSON, J |
| description | We have studied the efficacy of clonidine hydrochloride administered transdermally once a week for 9 to 15 weeks in 12 patients with mild to moderate hypertension. Clonidine reduced both supine and standing blood pressures on average, but only 8 subjects were responders, i.e. had a decrease in supine diastolic blood pressure to below 90 mm Hg or more than 10% from baseline. Supine heart rate was unchanged, but in the responders the orthostatic increase in heart rate was reduced by clonidine from baseline (p less than 0.05). Moreover, in all the patients the change in the orthostatic increase in heart rate was correlated with the change in supine diastolic pressure (p less than 0.05). Brachial artery blood flow, forearm arterial compliance, vascular resistance, and venous tone were not affected by clonidine. Thus, transdermal clonidine reduced blood pressure, probably by a baroreflex-mediated effect, but did not affect the vasculature of the forearm. |
| doi_str_mv | 10.1007/BF00544552 |
| format | Article |
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C ; PITHOIS-MERLI, I ; LEVENSON, J</creator><creatorcontrib>ACHIMASTOS, A ; GIRERD, X ; SIMON, A. C ; PITHOIS-MERLI, I ; LEVENSON, J</creatorcontrib><description>We have studied the efficacy of clonidine hydrochloride administered transdermally once a week for 9 to 15 weeks in 12 patients with mild to moderate hypertension. Clonidine reduced both supine and standing blood pressures on average, but only 8 subjects were responders, i.e. had a decrease in supine diastolic blood pressure to below 90 mm Hg or more than 10% from baseline. Supine heart rate was unchanged, but in the responders the orthostatic increase in heart rate was reduced by clonidine from baseline (p less than 0.05). Moreover, in all the patients the change in the orthostatic increase in heart rate was correlated with the change in supine diastolic pressure (p less than 0.05). Brachial artery blood flow, forearm arterial compliance, vascular resistance, and venous tone were not affected by clonidine. Thus, transdermal clonidine reduced blood pressure, probably by a baroreflex-mediated effect, but did not affect the vasculature of the forearm.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00544552</identifier><identifier>PMID: 3691604</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Administration, Cutaneous ; Adult ; Aged ; Antihypertensive agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Clonidine - administration & dosage ; Clonidine - therapeutic use ; Female ; Forearm - blood supply ; Heart Rate - drug effects ; Humans ; Hypertension - drug therapy ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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C</creatorcontrib><creatorcontrib>PITHOIS-MERLI, I</creatorcontrib><creatorcontrib>LEVENSON, J</creatorcontrib><title>The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>We have studied the efficacy of clonidine hydrochloride administered transdermally once a week for 9 to 15 weeks in 12 patients with mild to moderate hypertension. Clonidine reduced both supine and standing blood pressures on average, but only 8 subjects were responders, i.e. had a decrease in supine diastolic blood pressure to below 90 mm Hg or more than 10% from baseline. Supine heart rate was unchanged, but in the responders the orthostatic increase in heart rate was reduced by clonidine from baseline (p less than 0.05). Moreover, in all the patients the change in the orthostatic increase in heart rate was correlated with the change in supine diastolic pressure (p less than 0.05). Brachial artery blood flow, forearm arterial compliance, vascular resistance, and venous tone were not affected by clonidine. Thus, transdermal clonidine reduced blood pressure, probably by a baroreflex-mediated effect, but did not affect the vasculature of the forearm.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Aged</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Clonidine - administration & dosage</subject><subject>Clonidine - therapeutic use</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Plethysmography</subject><subject>Regional Blood Flow - drug effects</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFr3DAQhUVoSLdJLrkXdCg9FJyMLFm2jk1o2kKgl-RsZGlEVGxpK8mB_TH9r5XJkp4G5n28N7wh5IrBNQPob27vATohuq49ITsmeNswEOwd2QFw1kjVw3vyIeffAKxTwM_IGZeKSRA78vfxGSk65402Bxod1bQkHbLFtOiZupiWddbFx7CJZo7BWx-Q-kAXP1taIl1ihXVB-nzYYyoY8kbrYKkvefNGU2ddlRqlK5B8dd70FwxxzfRFZ7OFrAm3kA2ruajTckFOnZ4zXh7nOXm6__Z496N5-PX9593Xh8ZwxkojpIBBYNs5tMYx65TkTFk5ABu0gHYyrZyMa4WE3g5majWT3YRSuWFQTAt-Tj6_-u5T_LNiLuPis8F51gHrhWPfD70SHCr45RU0Keac0I375BedDiODcfvF-P8XFf54dF2nBe0beiy_6p-Oei1Az672bnx-w3opewUd_wfalZMO</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>ACHIMASTOS, A</creator><creator>GIRERD, X</creator><creator>SIMON, A. C</creator><creator>PITHOIS-MERLI, I</creator><creator>LEVENSON, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870101</creationdate><title>The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm</title><author>ACHIMASTOS, A ; GIRERD, X ; SIMON, A. C ; PITHOIS-MERLI, I ; LEVENSON, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-464084e25fedcf1df96319d68018a402bc26bcf24607d8cb2a165be69f8891a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Aged</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Clonidine - administration & dosage</topic><topic>Clonidine - therapeutic use</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Plethysmography</topic><topic>Regional Blood Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ACHIMASTOS, A</creatorcontrib><creatorcontrib>GIRERD, X</creatorcontrib><creatorcontrib>SIMON, A. C</creatorcontrib><creatorcontrib>PITHOIS-MERLI, I</creatorcontrib><creatorcontrib>LEVENSON, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ACHIMASTOS, A</au><au>GIRERD, X</au><au>SIMON, A. 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Supine heart rate was unchanged, but in the responders the orthostatic increase in heart rate was reduced by clonidine from baseline (p less than 0.05). Moreover, in all the patients the change in the orthostatic increase in heart rate was correlated with the change in supine diastolic pressure (p less than 0.05). Brachial artery blood flow, forearm arterial compliance, vascular resistance, and venous tone were not affected by clonidine. Thus, transdermal clonidine reduced blood pressure, probably by a baroreflex-mediated effect, but did not affect the vasculature of the forearm.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3691604</pmid><doi>10.1007/BF00544552</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of clinical pharmacology, 1987-01, Vol.33 (2), p.111-114 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Administration, Cutaneous Adult Aged Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Clonidine - administration & dosage Clonidine - therapeutic use Female Forearm - blood supply Heart Rate - drug effects Humans Hypertension - drug therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments Plethysmography Regional Blood Flow - drug effects |
| title | The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm |
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