Activation of human endothelial cell-type plasminogen activator inhibitor (PAI-1) by negatively charged phospholipids

The endothelial cell-type plasminogen activator inhibitor (PAI-1) may exist in an inactive, latent form that can be converted into an active form upon treatment of the protein with denaturants, such as sodium dodecyl sulfate, guanidine HCl, or urea. The present paper demonstrates that latent PAI-1 c...

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Veröffentlicht in:	The Journal of biological chemistry 1987-12, Vol.262 (36), p.17492-17496
Hauptverfasser:	Lambers, J W, Cammenga, M, König, B W, Mertens, K, Pannekoek, H, van Mourik, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Calcium Chloride - pharmacology Electrophoresis, Polyacrylamide Gel Fibrinolysis Fundamental and applied biological sciences. Psychology Glycoproteins - metabolism Humans Miscellaneous Phosphatidylcholines - pharmacology Phosphatidylserines - pharmacology phospholipids Phospholipids - pharmacology plasminogen activator inhibitor Plasminogen Inactivators Proteins Sodium Dodecyl Sulfate - pharmacology Tissue Plasminogen Activator - antagonists & inhibitors
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