Levodopa induces AP‐1 and CREB DNA‐binding activities in the rat striatum
In order to elucidate the effect of levodopa and bromocriptine on the DNA‐binding activities of transcription factors, AP‐1 and CREB DNA‐binding activities were investigated using gel‐shift assay. Intraperitoneal administration of 100 mg/kg levodopa with 50 mg/kg benserazide in rats increased both A...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 1995-12, Vol.49 (5‐6), p.291-294 |
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| container_title | Psychiatry and clinical neurosciences |
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| creator | KASHIHARA, KENICHI ISHIHARA, TAKESHI AKIYAMA, KAZUHUMI KURODA, SHIGETOSHI MORIMASA, TADAOMI SHOMORI, TOSHIKIYO |
| description | In order to elucidate the effect of levodopa and bromocriptine on the DNA‐binding activities of transcription factors, AP‐1 and CREB DNA‐binding activities were investigated using gel‐shift assay. Intraperitoneal administration of 100 mg/kg levodopa with 50 mg/kg benserazide in rats increased both AP‐1 and CREB DNA‐binding activities in the dorsolateral aspect of the striatum. The major proteins composing the increased AP‐1 were JunB and JunD. Bromocriptine at doses of 2.5 and 5.0 mg/kg, however, did not increase these binding activities. Present results suggest that levodopa but not bromocriptine induces these transcription‐regulating proteins in the striatum with normal dopaminergic functioning. |
| doi_str_mv | 10.1111/j.1440-1819.1995.tb01904.x |
| format | Article |
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Intraperitoneal administration of 100 mg/kg levodopa with 50 mg/kg benserazide in rats increased both AP‐1 and CREB DNA‐binding activities in the dorsolateral aspect of the striatum. The major proteins composing the increased AP‐1 were JunB and JunD. Bromocriptine at doses of 2.5 and 5.0 mg/kg, however, did not increase these binding activities. Present results suggest that levodopa but not bromocriptine induces these transcription‐regulating proteins in the striatum with normal dopaminergic functioning.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/j.1440-1819.1995.tb01904.x</identifier><identifier>PMID: 8726116</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Anticonvulsants. Antiepileptics. 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Drug treatments ; Proto-Oncogene Proteins c-jun - genetics ; Rats ; Rats, Sprague-Dawley ; Trans-Activators ; transcription factor ; Transcription Factor AP-1 - genetics ; Transcription Factors - genetics</subject><ispartof>Psychiatry and clinical neurosciences, 1995-12, Vol.49 (5‐6), p.291-294</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4271-b321fd9cd94214e8885dcb68c756e074923e45e04ce6e63c3ce5cef9787413ec3</citedby><cites>FETCH-LOGICAL-c4271-b321fd9cd94214e8885dcb68c756e074923e45e04ce6e63c3ce5cef9787413ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1819.1995.tb01904.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1819.1995.tb01904.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23909,23910,25118,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2761973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8726116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KASHIHARA, KENICHI</creatorcontrib><creatorcontrib>ISHIHARA, TAKESHI</creatorcontrib><creatorcontrib>AKIYAMA, KAZUHUMI</creatorcontrib><creatorcontrib>KURODA, SHIGETOSHI</creatorcontrib><creatorcontrib>MORIMASA, TADAOMI</creatorcontrib><creatorcontrib>SHOMORI, TOSHIKIYO</creatorcontrib><title>Levodopa induces AP‐1 and CREB DNA‐binding activities in the rat striatum</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>In order to elucidate the effect of levodopa and bromocriptine on the DNA‐binding activities of transcription factors, AP‐1 and CREB DNA‐binding activities were investigated using gel‐shift assay. Intraperitoneal administration of 100 mg/kg levodopa with 50 mg/kg benserazide in rats increased both AP‐1 and CREB DNA‐binding activities in the dorsolateral aspect of the striatum. The major proteins composing the increased AP‐1 were JunB and JunD. Bromocriptine at doses of 2.5 and 5.0 mg/kg, however, did not increase these binding activities. Present results suggest that levodopa but not bromocriptine induces these transcription‐regulating proteins in the striatum with normal dopaminergic functioning.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Antiparkinson Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>bromocriptine</subject><subject>Bromocriptine - pharmacology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - pathology</subject><subject>CRE</subject><subject>CREB-Binding Protein</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>gel‐shift assay</subject><subject>Gene Expression - drug effects</subject><subject>levodopa</subject><subject>Levodopa - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Nuclear Proteins - genetics</subject><subject>Parkinson's disease</subject><subject>Pharmacology. Drug treatments</subject><subject>Proto-Oncogene Proteins c-jun - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Trans-Activators</subject><subject>transcription factor</subject><subject>Transcription Factor AP-1 - genetics</subject><subject>Transcription Factors - genetics</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM9u1DAQh60KVErpI1SyEOKW4LEdO-aAtCzlj7SUqmrPluNMwKtsssRJaW88As_YJ6lXG-0dX8by75vx6CPkNbAc0nm3zkFKlkEJJgdjinysGBgm8_sjcnKInqW74CIDAeoFeRnjmjEmhIJjclxqrgDUCfm-wru-7reOhq6ePEa6uHr8-w-o62q6vL74SD9dLtJDleLQ_aTOj-EujCGBoaPjL6SDG2kch-DGafOKPG9cG_Fsrqfk9vPFzfJrtvrx5dtyscq85BqySnBoauNrIzlILMuyqH2lSq8LhUxLwwXKApn0qFAJLzwWHhujSy1BoBen5O1-7nbof08YR7sJ0WPbug77KVqdSKUVT-D7PeiHPsYBG7sdwsYNDxaY3bm0a7sTZnfC7M6lnV3a-9R8Pv8yVRusD62zvJS_mXMXvWubwXU-xAPGtQKjRcI-7LE_ocWH_1jAXi0vuQHxBKfHkPg</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>KASHIHARA, KENICHI</creator><creator>ISHIHARA, TAKESHI</creator><creator>AKIYAMA, KAZUHUMI</creator><creator>KURODA, SHIGETOSHI</creator><creator>MORIMASA, TADAOMI</creator><creator>SHOMORI, TOSHIKIYO</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199512</creationdate><title>Levodopa induces AP‐1 and CREB DNA‐binding activities in the rat striatum</title><author>KASHIHARA, KENICHI ; ISHIHARA, TAKESHI ; AKIYAMA, KAZUHUMI ; KURODA, SHIGETOSHI ; MORIMASA, TADAOMI ; SHOMORI, TOSHIKIYO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4271-b321fd9cd94214e8885dcb68c756e074923e45e04ce6e63c3ce5cef9787413ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Antiparkinson Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>bromocriptine</topic><topic>Bromocriptine - pharmacology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - pathology</topic><topic>CRE</topic><topic>CREB-Binding Protein</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>gel‐shift assay</topic><topic>Gene Expression - drug effects</topic><topic>levodopa</topic><topic>Levodopa - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Nuclear Proteins - genetics</topic><topic>Parkinson's disease</topic><topic>Pharmacology. Drug treatments</topic><topic>Proto-Oncogene Proteins c-jun - genetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Trans-Activators</topic><topic>transcription factor</topic><topic>Transcription Factor AP-1 - genetics</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KASHIHARA, KENICHI</creatorcontrib><creatorcontrib>ISHIHARA, TAKESHI</creatorcontrib><creatorcontrib>AKIYAMA, KAZUHUMI</creatorcontrib><creatorcontrib>KURODA, SHIGETOSHI</creatorcontrib><creatorcontrib>MORIMASA, TADAOMI</creatorcontrib><creatorcontrib>SHOMORI, TOSHIKIYO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KASHIHARA, KENICHI</au><au>ISHIHARA, TAKESHI</au><au>AKIYAMA, KAZUHUMI</au><au>KURODA, SHIGETOSHI</au><au>MORIMASA, TADAOMI</au><au>SHOMORI, TOSHIKIYO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levodopa induces AP‐1 and CREB DNA‐binding activities in the rat striatum</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>1995-12</date><risdate>1995</risdate><volume>49</volume><issue>5‐6</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>In order to elucidate the effect of levodopa and bromocriptine on the DNA‐binding activities of transcription factors, AP‐1 and CREB DNA‐binding activities were investigated using gel‐shift assay. Intraperitoneal administration of 100 mg/kg levodopa with 50 mg/kg benserazide in rats increased both AP‐1 and CREB DNA‐binding activities in the dorsolateral aspect of the striatum. The major proteins composing the increased AP‐1 were JunB and JunD. Bromocriptine at doses of 2.5 and 5.0 mg/kg, however, did not increase these binding activities. Present results suggest that levodopa but not bromocriptine induces these transcription‐regulating proteins in the striatum with normal dopaminergic functioning.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8726116</pmid><doi>10.1111/j.1440-1819.1995.tb01904.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1323-1316 |
| ispartof | Psychiatry and clinical neurosciences, 1995-12, Vol.49 (5‐6), p.291-294 |
| issn | 1323-1316 1440-1819 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - pharmacology Biological and medical sciences bromocriptine Bromocriptine - pharmacology Corpus Striatum - drug effects Corpus Striatum - pathology CRE CREB-Binding Protein DNA-Binding Proteins - genetics Dose-Response Relationship, Drug gel‐shift assay Gene Expression - drug effects levodopa Levodopa - pharmacology Male Medical sciences Neuropharmacology Nuclear Proteins - genetics Parkinson's disease Pharmacology. Drug treatments Proto-Oncogene Proteins c-jun - genetics Rats Rats, Sprague-Dawley Trans-Activators transcription factor Transcription Factor AP-1 - genetics Transcription Factors - genetics |
| title | Levodopa induces AP‐1 and CREB DNA‐binding activities in the rat striatum |
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