Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease
Blood donors of the Madrid area show a 6% frequency of apolipoprotein E genotype carrying allele ε4. This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages >60 years. The frequency (34%) of the alle...
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| Veröffentlicht in: | Journal of the neurological sciences 1995-12, Vol.134 (1), p.146-149 |
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| container_title | Journal of the neurological sciences |
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| creator | Ibarreta, Dolores Gómez-Isla, Teresa Portera-Sánchez, Alberto Parrilla, Roberto Ayuso, Matilde S. |
| description | Blood donors of the Madrid area show a 6% frequency of apolipoprotein E genotype carrying allele ε4. This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages >60 years. The frequency (34%) of the allele ε4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele ε4. No increased frequency in allele ε4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals. |
| doi_str_mv | 10.1016/0022-510X(95)00238-3 |
| format | Article |
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This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages >60 years. The frequency (34%) of the allele ε4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele ε4. No increased frequency in allele ε4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(95)00238-3</identifier><identifier>PMID: 8747858</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E ; Apolipoproteins E - genetics ; Biological and medical sciences ; Female ; Genotype ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lewy Bodies - genetics ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Neurofibrillary Tangles - genetics ; Parkinson Disease - genetics ; Parkinson's disease ; Pathology. Cytology. Biochemistry. Spectrometry. 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This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages >60 years. The frequency (34%) of the allele ε4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele ε4. No increased frequency in allele ε4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lewy Bodies - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurofibrillary Tangles - genetics</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Spain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibarreta, Dolores</creatorcontrib><creatorcontrib>Gómez-Isla, Teresa</creatorcontrib><creatorcontrib>Portera-Sánchez, Alberto</creatorcontrib><creatorcontrib>Parrilla, Roberto</creatorcontrib><creatorcontrib>Ayuso, Matilde S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibarreta, Dolores</au><au>Gómez-Isla, Teresa</au><au>Portera-Sánchez, Alberto</au><au>Parrilla, Roberto</au><au>Ayuso, Matilde S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>134</volume><issue>1</issue><spage>146</spage><epage>149</epage><pages>146-149</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Blood donors of the Madrid area show a 6% frequency of apolipoprotein E genotype carrying allele ε4. This frequency is smaller than other populations of Caucasian origin. This proportion decreases to 4% in a selected sample of healthy individuals of ages >60 years. The frequency (34%) of the allele ε4 was significantly increased in patients of late onset Alzheimer's disease, similarly to other populations. An earlier age of onset of the dementia is observed in the patients of late-onset Alzheimer's disease carrying the allele ε4. No increased frequency in allele ε4 frequency was found in patients of early-onset Alzheimer's disease. Patients of Parkinson's disease do not show any differences in the frequency of the alleles of apolipoprotein E when compared with healthy individuals.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>8747858</pmid><doi>10.1016/0022-510X(95)00238-3</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoproteins E - genetics Biological and medical sciences Female Genotype Humans Investigative techniques, diagnostic techniques (general aspects) Lewy Bodies - genetics Male Medical sciences Middle Aged Nervous system Neurofibrillary Tangles - genetics Parkinson Disease - genetics Parkinson's disease Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Spain |
| title | Apolipoprotein E genotype in Spanish patients of Alzheimer's or Parkinson's disease |
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