Non-invasive endoscopic technique to assess gastrointestinal perfusion
Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non‐invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion meas...
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| Veröffentlicht in: | British journal of surgery 1987-11, Vol.74 (11), p.1053-1055 |
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| creator | Allen, P. I. M. Gourevitch, D. Goldman, M. |
| description | Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non‐invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion measured with an electromagnetic flow probe. At maximum flow, LD measurements were made at three sites to compare mucosal with serosal readings. Flow rate was varied (1‐38 ml/min) and measurements of microcirculatory flux obtained using LD, and of oxygen tension using a serosal OE. A progressive trend towards increasing flux was demonstrated from caecum to rectum—serosa: 46·8 ± 18·7 V (caecum), 52·6 ± 17·9 V (mid‐colon) and 61·3 ± 17·6 V (rectum). A parallel trend was observed in mucosal values: 41·1 ± 18·2 V (caecum), 45·7 ± 15·2 V (mid‐colon) and 54·1 ± 15·1 V (rectum). At all sites, serosal and mucosal values were not significantly different (Student's t test). LD serosal values correlated significantly with EM flow (r = 0·544, 0·01 > P > 0·001). A similar linear correlation was found between OE and EM flow (r = 0·65, P P > 0·01). Endoscopic LD assessment of colonic microcirculation accurately reflects changes in blood flow. |
| doi_str_mv | 10.1002/bjs.1800741131 |
| format | Article |
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I. M. ; Gourevitch, D. ; Goldman, M.</creator><creatorcontrib>Allen, P. I. M. ; Gourevitch, D. ; Goldman, M.</creatorcontrib><description>Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non‐invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion measured with an electromagnetic flow probe. At maximum flow, LD measurements were made at three sites to compare mucosal with serosal readings. Flow rate was varied (1‐38 ml/min) and measurements of microcirculatory flux obtained using LD, and of oxygen tension using a serosal OE. A progressive trend towards increasing flux was demonstrated from caecum to rectum—serosa: 46·8 ± 18·7 V (caecum), 52·6 ± 17·9 V (mid‐colon) and 61·3 ± 17·6 V (rectum). A parallel trend was observed in mucosal values: 41·1 ± 18·2 V (caecum), 45·7 ± 15·2 V (mid‐colon) and 54·1 ± 15·1 V (rectum). At all sites, serosal and mucosal values were not significantly different (Student's t test). LD serosal values correlated significantly with EM flow (r = 0·544, 0·01 > P > 0·001). A similar linear correlation was found between OE and EM flow (r = 0·65, P<0·001). Oxygen tension measurements varied as expected with microcirculatory flux (r = 0·441, 0·02 > P > 0·01). Endoscopic LD assessment of colonic microcirculation accurately reflects changes in blood flow.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800741131</identifier><identifier>PMID: 2961398</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Colon - blood supply ; Colonic blood flow ; Colonoscopy - methods ; Dogs ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; laser Doppler ; Medical sciences ; Microcirculation ; Miscellaneous ; Oximetry ; Regional Blood Flow ; Rheology</subject><ispartof>British journal of surgery, 1987-11, Vol.74 (11), p.1053-1055</ispartof><rights>Copyright © 1987 British Journal of Surgery Society Ltd.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2831-583a516d96dd72bf32b34c9eaea32c4764db297863760ad6df866764ffa573f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800741131$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800741131$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7507243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2961398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, P. I. M.</creatorcontrib><creatorcontrib>Gourevitch, D.</creatorcontrib><creatorcontrib>Goldman, M.</creatorcontrib><title>Non-invasive endoscopic technique to assess gastrointestinal perfusion</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non‐invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion measured with an electromagnetic flow probe. At maximum flow, LD measurements were made at three sites to compare mucosal with serosal readings. Flow rate was varied (1‐38 ml/min) and measurements of microcirculatory flux obtained using LD, and of oxygen tension using a serosal OE. A progressive trend towards increasing flux was demonstrated from caecum to rectum—serosa: 46·8 ± 18·7 V (caecum), 52·6 ± 17·9 V (mid‐colon) and 61·3 ± 17·6 V (rectum). A parallel trend was observed in mucosal values: 41·1 ± 18·2 V (caecum), 45·7 ± 15·2 V (mid‐colon) and 54·1 ± 15·1 V (rectum). At all sites, serosal and mucosal values were not significantly different (Student's t test). LD serosal values correlated significantly with EM flow (r = 0·544, 0·01 > P > 0·001). A similar linear correlation was found between OE and EM flow (r = 0·65, P<0·001). Oxygen tension measurements varied as expected with microcirculatory flux (r = 0·441, 0·02 > P > 0·01). Endoscopic LD assessment of colonic microcirculation accurately reflects changes in blood flow.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colon - blood supply</subject><subject>Colonic blood flow</subject><subject>Colonoscopy - methods</subject><subject>Dogs</subject><subject>Investigative techniques of hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>laser Doppler</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>Miscellaneous</subject><subject>Oximetry</subject><subject>Regional Blood Flow</subject><subject>Rheology</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUD1PwzAQtRColMLKhpQBsaXYvsRORii0fFSABIjRchwHDKkTcinQf09QozKd7n2c7j1CDhkdM0r5afaOY5ZQKiPGgG2RIQMRh5yJZJsMaYeHDDjskj3Ed0oZ0JgPyICngkGaDMn0rvKh818a3ZcNrM8rNFXtTNBa8-bd59IGbRVoRIsYvGpsm8r51mLrvC6D2jbFEl3l98lOoUu0B_0ckefp5dPkKpzfz64nZ_PQ8ARYGCegYybyVOS55FkBPIPIpFZbDdxEUkR5xlOZCJCC6lzkRSJEhxaFjiUUMYzIyfpu3VTdb9iqhUNjy1J7Wy1RSZnISHaBR-SoFy6zhc1V3biFblaqD97xxz2v0eiyaLQ3DjcyGVPJI-hk6Vr27Uq72tCMqr_yVVe--i9fnd88_m-dN1x7Hbb2Z-PVzYcSEmSsXu5m6kk-TGYXty-KwS9s54di</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>Allen, P. I. M.</creator><creator>Gourevitch, D.</creator><creator>Goldman, M.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198711</creationdate><title>Non-invasive endoscopic technique to assess gastrointestinal perfusion</title><author>Allen, P. I. M. ; Gourevitch, D. ; Goldman, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2831-583a516d96dd72bf32b34c9eaea32c4764db297863760ad6df866764ffa573f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colon - blood supply</topic><topic>Colonic blood flow</topic><topic>Colonoscopy - methods</topic><topic>Dogs</topic><topic>Investigative techniques of hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>laser Doppler</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>Miscellaneous</topic><topic>Oximetry</topic><topic>Regional Blood Flow</topic><topic>Rheology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, P. I. M.</creatorcontrib><creatorcontrib>Gourevitch, D.</creatorcontrib><creatorcontrib>Goldman, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, P. I. M.</au><au>Gourevitch, D.</au><au>Goldman, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasive endoscopic technique to assess gastrointestinal perfusion</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1987-11</date><risdate>1987</risdate><volume>74</volume><issue>11</issue><spage>1053</spage><epage>1055</epage><pages>1053-1055</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non‐invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion measured with an electromagnetic flow probe. At maximum flow, LD measurements were made at three sites to compare mucosal with serosal readings. Flow rate was varied (1‐38 ml/min) and measurements of microcirculatory flux obtained using LD, and of oxygen tension using a serosal OE. A progressive trend towards increasing flux was demonstrated from caecum to rectum—serosa: 46·8 ± 18·7 V (caecum), 52·6 ± 17·9 V (mid‐colon) and 61·3 ± 17·6 V (rectum). A parallel trend was observed in mucosal values: 41·1 ± 18·2 V (caecum), 45·7 ± 15·2 V (mid‐colon) and 54·1 ± 15·1 V (rectum). At all sites, serosal and mucosal values were not significantly different (Student's t test). LD serosal values correlated significantly with EM flow (r = 0·544, 0·01 > P > 0·001). A similar linear correlation was found between OE and EM flow (r = 0·65, P<0·001). Oxygen tension measurements varied as expected with microcirculatory flux (r = 0·441, 0·02 > P > 0·01). Endoscopic LD assessment of colonic microcirculation accurately reflects changes in blood flow.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>2961398</pmid><doi>10.1002/bjs.1800741131</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Colon - blood supply Colonic blood flow Colonoscopy - methods Dogs Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) laser Doppler Medical sciences Microcirculation Miscellaneous Oximetry Regional Blood Flow Rheology |
| title | Non-invasive endoscopic technique to assess gastrointestinal perfusion |
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