Nicorandil Augments Regional Ischemia-Induced Monophasic Action Potential Shortening and Potassium Accumulation without Serious Proarrhythmia

Nicorandil is a clinically used nitrovasodilator that has a property as an opener of ATP-sensitive potassium (KATP) channels in vitro. We examined whether nicorandil at a clinically used dose augmented regional ischemia-induced monophasic action potential (MAP) shortening and increase in extracellul...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1995-12, Vol.26 (6), p.949-956
Hauptverfasser:	Miyazaki, Toshihisa, Moritani, Kazunori, Miyoshi, Shunichiro, Asanagi, Mika, Zhao, Li-Sin, Mitamura, Hideo, Ogawa, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Coronary Circulation - drug effects Dogs Medical sciences Myocardial Ischemia - physiopathology Niacinamide - analogs & derivatives Niacinamide - blood Niacinamide - pharmacology Nicorandil Pharmacology. Drug treatments Potassium - metabolism Potassium Channels - drug effects Vasodilator Agents - pharmacology Ventricular Fibrillation - prevention & control
Online-Zugang:	Volltext
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