Rapid evolution of RNA viruses
The high error rate inherent in all RNA synthesis provides RNA virus genomes with extremely high mutation rates. Thus nearly all large RNA virus clonal populations are quasispecies collections of differing, related genomes (14, 49). These rapidly mutating populations can remain remarkably stable und...
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| Veröffentlicht in: | Annual review of microbiology 1987-01, Vol.41 (1), p.409-433 |
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| container_title | Annual review of microbiology |
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| creator | Steinhauer, D.A Holland, J.J |
| description | The high error rate inherent in all RNA synthesis provides RNA virus genomes with extremely high mutation rates. Thus nearly all large RNA virus clonal populations are quasispecies collections of differing, related genomes (14, 49). These rapidly mutating populations can remain remarkably stable under certain conditions of replication. Under other conditions, virus-population equilibria become disturbed, and extremely rapid evolution can result. This extreme variability and rapid evolution can cause severe problems with previously unknown virus diseases (such as AIDS). It also presents daunting challenges for the design of effective vaccines for the control of diseases caused by rapidly evolving RNA virus populations. |
| doi_str_mv | 10.1146/annurev.mi.41.100187.002205 |
| format | Article |
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Thus nearly all large RNA virus clonal populations are quasispecies collections of differing, related genomes (14, 49). These rapidly mutating populations can remain remarkably stable under certain conditions of replication. Under other conditions, virus-population equilibria become disturbed, and extremely rapid evolution can result. This extreme variability and rapid evolution can cause severe problems with previously unknown virus diseases (such as AIDS). It also presents daunting challenges for the design of effective vaccines for the control of diseases caused by rapidly evolving RNA virus populations.</description><identifier>ISSN: 0066-4227</identifier><identifier>EISSN: 1545-3251</identifier><identifier>DOI: 10.1146/annurev.mi.41.100187.002205</identifier><identifier>PMID: 3318675</identifier><identifier>CODEN: ARMIAZ</identifier><language>eng</language><publisher>Palo Alto, CA: Annual Reviews</publisher><subject>Acute Disease ; ANTIGENE ; ANTIGENOS ; ANTIGENS ; Applied sciences ; ARN ; Biological Evolution ; CHEMICOPHYSICAL PROPERTIES ; Chronic Disease ; EVOLUCION ; EVOLUTION ; Exact sciences and technology ; Genes, Viral ; GENETIC VARIATION ; GENOMAS ; GENOME ; GENOMES ; HETEROGENEITY ; Humans ; MUTACION ; MUTATION ; Other techniques and industries ; PLANT VIRUSES ; PLASTICITY ; PROPIEDADES FISICO-QUIMICAS ; PROPRIETE PHYSICO-CHIMIQUE ; RECOMBINACION ; RECOMBINAISON ; RECOMBINATION ; RNA ; RNA Viruses - genetics ; RNA Viruses - pathogenicity ; VARIACION GENETICA ; VARIATION GENETIQUE ; Virulence ; VIRUS ; VIRUS DE LAS PLANTAS ; VIRUS DES VEGETAUX ; Virus Diseases - microbiology ; VIRUSES</subject><ispartof>Annual review of microbiology, 1987-01, Vol.41 (1), p.409-433</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296t-477adcd96df9189e35a5f2fe370bb9abc7c453dcb3c930a7c161fc0da64958cb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4168,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7847653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3318675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinhauer, D.A</creatorcontrib><creatorcontrib>Holland, J.J</creatorcontrib><title>Rapid evolution of RNA viruses</title><title>Annual review of microbiology</title><addtitle>Annu Rev Microbiol</addtitle><description>The high error rate inherent in all RNA synthesis provides RNA virus genomes with extremely high mutation rates. Thus nearly all large RNA virus clonal populations are quasispecies collections of differing, related genomes (14, 49). These rapidly mutating populations can remain remarkably stable under certain conditions of replication. Under other conditions, virus-population equilibria become disturbed, and extremely rapid evolution can result. This extreme variability and rapid evolution can cause severe problems with previously unknown virus diseases (such as AIDS). It also presents daunting challenges for the design of effective vaccines for the control of diseases caused by rapidly evolving RNA virus populations.</description><subject>Acute Disease</subject><subject>ANTIGENE</subject><subject>ANTIGENOS</subject><subject>ANTIGENS</subject><subject>Applied sciences</subject><subject>ARN</subject><subject>Biological Evolution</subject><subject>CHEMICOPHYSICAL PROPERTIES</subject><subject>Chronic Disease</subject><subject>EVOLUCION</subject><subject>EVOLUTION</subject><subject>Exact sciences and technology</subject><subject>Genes, Viral</subject><subject>GENETIC VARIATION</subject><subject>GENOMAS</subject><subject>GENOME</subject><subject>GENOMES</subject><subject>HETEROGENEITY</subject><subject>Humans</subject><subject>MUTACION</subject><subject>MUTATION</subject><subject>Other techniques and industries</subject><subject>PLANT VIRUSES</subject><subject>PLASTICITY</subject><subject>PROPIEDADES FISICO-QUIMICAS</subject><subject>PROPRIETE PHYSICO-CHIMIQUE</subject><subject>RECOMBINACION</subject><subject>RECOMBINAISON</subject><subject>RECOMBINATION</subject><subject>RNA</subject><subject>RNA Viruses - genetics</subject><subject>RNA Viruses - pathogenicity</subject><subject>VARIACION GENETICA</subject><subject>VARIATION GENETIQUE</subject><subject>Virulence</subject><subject>VIRUS</subject><subject>VIRUS DE LAS PLANTAS</subject><subject>VIRUS DES VEGETAUX</subject><subject>Virus Diseases - microbiology</subject><subject>VIRUSES</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKw0AQhhdRaq2-gKAUFO8SZ7NnvCrFExSFaq-XzWZXIjnU3abg2xtJ6NXAzPf_Ax9CNxhSjCm_N03TBbdP6zKlOMUAWIoUIMuAHaEpZpQlJGP4GE0BOE9ololTdBbjNwBQAWqCJoRgyQWbouu12ZbF3O3bqtuVbTNv_Xz9tpjvy9BFF8_RiTdVdBfjnKHN0-Pn8iVZvT-_LherxGaK7xIqhClsoXjhFZbKEWaYz7wjAvJcmdwKSxkpbE6sImCExRx7C4XhVDHZr2fobujdhvanc3Gn6zJaV1WmcW0XtRBSEOg7ZuhhAG1oYwzO620oaxN-NQb9b0ePdvoCTbEe7OjBTp--Gt90ee2KQ3bU0d9vx7uJ1lQ-mMaW8YAJSQVnpMcuB8ybVpuv0CObDykZVpySP6Ead6s</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Steinhauer, D.A</creator><creator>Holland, J.J</creator><general>Annual Reviews</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870101</creationdate><title>Rapid evolution of RNA viruses</title><author>Steinhauer, D.A ; Holland, J.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-477adcd96df9189e35a5f2fe370bb9abc7c453dcb3c930a7c161fc0da64958cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acute Disease</topic><topic>ANTIGENE</topic><topic>ANTIGENOS</topic><topic>ANTIGENS</topic><topic>Applied sciences</topic><topic>ARN</topic><topic>Biological Evolution</topic><topic>CHEMICOPHYSICAL PROPERTIES</topic><topic>Chronic Disease</topic><topic>EVOLUCION</topic><topic>EVOLUTION</topic><topic>Exact sciences and technology</topic><topic>Genes, Viral</topic><topic>GENETIC VARIATION</topic><topic>GENOMAS</topic><topic>GENOME</topic><topic>GENOMES</topic><topic>HETEROGENEITY</topic><topic>Humans</topic><topic>MUTACION</topic><topic>MUTATION</topic><topic>Other techniques and industries</topic><topic>PLANT VIRUSES</topic><topic>PLASTICITY</topic><topic>PROPIEDADES FISICO-QUIMICAS</topic><topic>PROPRIETE PHYSICO-CHIMIQUE</topic><topic>RECOMBINACION</topic><topic>RECOMBINAISON</topic><topic>RECOMBINATION</topic><topic>RNA</topic><topic>RNA Viruses - genetics</topic><topic>RNA Viruses - pathogenicity</topic><topic>VARIACION GENETICA</topic><topic>VARIATION GENETIQUE</topic><topic>Virulence</topic><topic>VIRUS</topic><topic>VIRUS DE LAS PLANTAS</topic><topic>VIRUS DES VEGETAUX</topic><topic>Virus Diseases - microbiology</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinhauer, D.A</creatorcontrib><creatorcontrib>Holland, J.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinhauer, D.A</au><au>Holland, J.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid evolution of RNA viruses</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>41</volume><issue>1</issue><spage>409</spage><epage>433</epage><pages>409-433</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><coden>ARMIAZ</coden><abstract>The high error rate inherent in all RNA synthesis provides RNA virus genomes with extremely high mutation rates. Thus nearly all large RNA virus clonal populations are quasispecies collections of differing, related genomes (14, 49). These rapidly mutating populations can remain remarkably stable under certain conditions of replication. Under other conditions, virus-population equilibria become disturbed, and extremely rapid evolution can result. This extreme variability and rapid evolution can cause severe problems with previously unknown virus diseases (such as AIDS). It also presents daunting challenges for the design of effective vaccines for the control of diseases caused by rapidly evolving RNA virus populations.</abstract><cop>Palo Alto, CA</cop><pub>Annual Reviews</pub><pmid>3318675</pmid><doi>10.1146/annurev.mi.41.100187.002205</doi><tpages>25</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4227 |
| ispartof | Annual review of microbiology, 1987-01, Vol.41 (1), p.409-433 |
| issn | 0066-4227 1545-3251 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77873045 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Acute Disease ANTIGENE ANTIGENOS ANTIGENS Applied sciences ARN Biological Evolution CHEMICOPHYSICAL PROPERTIES Chronic Disease EVOLUCION EVOLUTION Exact sciences and technology Genes, Viral GENETIC VARIATION GENOMAS GENOME GENOMES HETEROGENEITY Humans MUTACION MUTATION Other techniques and industries PLANT VIRUSES PLASTICITY PROPIEDADES FISICO-QUIMICAS PROPRIETE PHYSICO-CHIMIQUE RECOMBINACION RECOMBINAISON RECOMBINATION RNA RNA Viruses - genetics RNA Viruses - pathogenicity VARIACION GENETICA VARIATION GENETIQUE Virulence VIRUS VIRUS DE LAS PLANTAS VIRUS DES VEGETAUX Virus Diseases - microbiology VIRUSES |
| title | Rapid evolution of RNA viruses |
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