Does essential hypertension lead to renal failure?
Systemic hypertension can lead to renal failure in blacks. The key lesion is severe intimal thickening in interlobular arteries without fibrinoid necrosis. Hypertensive endothelial injury is the likely root cause of the intimal thickening. High potassium diets prevent wall thickening of small renal...
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| Veröffentlicht in: | The American journal of cardiology 1987-12, Vol.60 (17), p.42-46 |
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| container_title | The American journal of cardiology |
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| creator | Tobian, Louis |
| description | Systemic hypertension can lead to renal failure in blacks. The key lesion is severe intimal thickening in interlobular arteries without fibrinoid necrosis. Hypertensive endothelial injury is the likely root cause of the intimal thickening. High potassium diets prevent wall thickening of small renal arteries and arterioles in hypertensive Dahl S rats and also greatly reduce both medial and intimal thickening of the aorta and mesenteric and carotid arteries in spontaneously hypertensive stroke-prone rats. In view of this, it is quite likely that the low potassium diet characteristically seen in blacks exaggerates the hypertensive intimal thickening. A high potassium diet could possibly preserve these arteries and avert much renal failure. |
| doi_str_mv | 10.1016/0002-9149(87)90458-9 |
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The key lesion is severe intimal thickening in interlobular arteries without fibrinoid necrosis. Hypertensive endothelial injury is the likely root cause of the intimal thickening. High potassium diets prevent wall thickening of small renal arteries and arterioles in hypertensive Dahl S rats and also greatly reduce both medial and intimal thickening of the aorta and mesenteric and carotid arteries in spontaneously hypertensive stroke-prone rats. In view of this, it is quite likely that the low potassium diet characteristically seen in blacks exaggerates the hypertensive intimal thickening. 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The key lesion is severe intimal thickening in interlobular arteries without fibrinoid necrosis. Hypertensive endothelial injury is the likely root cause of the intimal thickening. High potassium diets prevent wall thickening of small renal arteries and arterioles in hypertensive Dahl S rats and also greatly reduce both medial and intimal thickening of the aorta and mesenteric and carotid arteries in spontaneously hypertensive stroke-prone rats. In view of this, it is quite likely that the low potassium diet characteristically seen in blacks exaggerates the hypertensive intimal thickening. A high potassium diet could possibly preserve these arteries and avert much renal failure.</description><subject>Animals</subject><subject>Arteries - pathology</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Cerebrovascular Disorders - prevention & control</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred Strains</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mo67r6DRR6Ej1UM03zuiiyPmHBi55Dmk4w0m3XpBX229t1F4-ehuH_GOZHyCnQK6AgrimlRa6h1BdKXmpacpXrPTIFJXUOGtg-mf5ZDslRSp_jCsDFhEyYUFLRckqK-w5Thilh2wfbZB_rFcYe2xS6NmvQ1lnfZRHbUfI2NEPE22Ny4G2T8GQ3Z-T98eFt_pwvXp9e5neL3DEu-5x7cAUWAi3jyJyj2gohrXBecyvRO6eFBaxoQStblV4Bd7xQ4_CMoRdsRs63vavYfQ2YerMMyWHT2Ba7IRkplQSqYDSWW6OLXUoRvVnFsLRxbYCaDSqz4WA2HIyS5heV0WPsbNc_VEus_0I7NqN-s9VxfPI7YDTJBWwd1iGi603dhf8P_ACAb3fO</recordid><startdate>19871214</startdate><enddate>19871214</enddate><creator>Tobian, Louis</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871214</creationdate><title>Does essential hypertension lead to renal failure?</title><author>Tobian, Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-5f1c2e26ea35e3cc09a667a6cf95a7efcc96a1eb020bab4f815c528815f33ef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Arteries - pathology</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Cerebrovascular Disorders - prevention & control</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tobian, Louis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tobian, Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does essential hypertension lead to renal failure?</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1987-12-14</date><risdate>1987</risdate><volume>60</volume><issue>17</issue><spage>42</spage><epage>46</epage><pages>42-46</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Systemic hypertension can lead to renal failure in blacks. The key lesion is severe intimal thickening in interlobular arteries without fibrinoid necrosis. Hypertensive endothelial injury is the likely root cause of the intimal thickening. High potassium diets prevent wall thickening of small renal arteries and arterioles in hypertensive Dahl S rats and also greatly reduce both medial and intimal thickening of the aorta and mesenteric and carotid arteries in spontaneously hypertensive stroke-prone rats. In view of this, it is quite likely that the low potassium diet characteristically seen in blacks exaggerates the hypertensive intimal thickening. A high potassium diet could possibly preserve these arteries and avert much renal failure.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3687804</pmid><doi>10.1016/0002-9149(87)90458-9</doi><tpages>5</tpages></addata></record> |
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| issn | 0002-9149 1879-1913 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arteries - pathology Cerebrovascular Disorders - etiology Cerebrovascular Disorders - physiopathology Cerebrovascular Disorders - prevention & control Humans Hypertension - complications Hypertension - pathology Hypertension - physiopathology Kidney - pathology Kidney - physiopathology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - physiopathology Rats Rats, Inbred SHR Rats, Inbred Strains |
| title | Does essential hypertension lead to renal failure? |
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