A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats
We report evidence based on equilibrium binding, electrophoretic, autoradiographic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). We show th...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1987-11, Vol.148 (3), p.1165-1173 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 148 |
| creator | Savu, Lia Vranckx, Roger Maya, Michelle Nunez, Emmanuel A. |
| description | We report evidence based on equilibrium binding, electrophoretic, autoradiographic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). We show that in the sera of postnatal developing animals, the thyroxine and the triiodothyronine binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TßG.
In the adult serum, the TBG persists in decreased amounts : it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone. |
| doi_str_mv | 10.1016/S0006-291X(87)80255-3 |
| format | Article |
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In the adult serum, the TBG persists in decreased amounts : it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(87)80255-3</identifier><identifier>PMID: 2446606</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Age Factors ; alpha-Fetoproteins - metabolism ; Animals ; Applied sciences ; Exact sciences and technology ; Other techniques and industries ; Prealbumin - metabolism ; proteins ; Rats ; Thyroxine - metabolism ; thyroxine-binding globulin ; Thyroxine-Binding Proteins - metabolism ; Triiodothyronine - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1987-11, Vol.148 (3), p.1165-1173</ispartof><rights>1987 Academic Press, Inc.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-888960ed0afb72263c51fe3be7c65bc5574b7020d57bf7ba3289d5b9986182e3</citedby><cites>FETCH-LOGICAL-c420t-888960ed0afb72263c51fe3be7c65bc5574b7020d57bf7ba3289d5b9986182e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-291X(87)80255-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7072538$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2446606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savu, Lia</creatorcontrib><creatorcontrib>Vranckx, Roger</creatorcontrib><creatorcontrib>Maya, Michelle</creatorcontrib><creatorcontrib>Nunez, Emmanuel A.</creatorcontrib><title>A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>We report evidence based on equilibrium binding, electrophoretic, autoradiographic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). We show that in the sera of postnatal developing animals, the thyroxine and the triiodothyronine binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TßG.
In the adult serum, the TBG persists in decreased amounts : it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone.</description><subject>Age Factors</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Exact sciences and technology</subject><subject>Other techniques and industries</subject><subject>Prealbumin - metabolism</subject><subject>proteins</subject><subject>Rats</subject><subject>Thyroxine - metabolism</subject><subject>thyroxine-binding globulin</subject><subject>Thyroxine-Binding Proteins - metabolism</subject><subject>Triiodothyronine - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJSTdpf0JAhxKSg9uRbH34FNLQfECgh-4hN6GPcaJWa28kOzT_vt7ssteAYEDzvDPDQ8gJg28MmPz-GwBkxVv2cKbVuQYuRFV_IAsGLVScQXNAFnvkEzkq5Q8AY41sD8khbxopQS7IwyUdn17z8C_2SF3sQ-wf6WMa3JRiT8-WP27OqxT_Il3nYcT5a37jE9KC2dKhowFfMA3rTcr2gdowpZFmO5bP5GNnU8Evu3pMltc_l1e31f2vm7ury_vKNxzGSmvdSsAAtnOKc1l7wTqsHSovhfNCqMYp4BCEcp1ytua6DcK1rZZMc6yPyel27Hzf84RlNKtYPKZkexymYpTSCpoG3gWZYKrm0M6g2II-D6Vk7Mw6x5XNr4aB2Zg3b-bNRqvRyryZN_WcO9ktmNwKwz61Uz33v-76tnibumx7H8seU6C4qPWMXWwxnKW9RMym-Ii9xxAz-tGEIb5zyH8ptJ6f</recordid><startdate>19871113</startdate><enddate>19871113</enddate><creator>Savu, Lia</creator><creator>Vranckx, Roger</creator><creator>Maya, Michelle</creator><creator>Nunez, Emmanuel A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19871113</creationdate><title>A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats</title><author>Savu, Lia ; Vranckx, Roger ; Maya, Michelle ; Nunez, Emmanuel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-888960ed0afb72263c51fe3be7c65bc5574b7020d57bf7ba3289d5b9986182e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Age Factors</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Exact sciences and technology</topic><topic>Other techniques and industries</topic><topic>Prealbumin - metabolism</topic><topic>proteins</topic><topic>Rats</topic><topic>Thyroxine - metabolism</topic><topic>thyroxine-binding globulin</topic><topic>Thyroxine-Binding Proteins - metabolism</topic><topic>Triiodothyronine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savu, Lia</creatorcontrib><creatorcontrib>Vranckx, Roger</creatorcontrib><creatorcontrib>Maya, Michelle</creatorcontrib><creatorcontrib>Nunez, Emmanuel A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savu, Lia</au><au>Vranckx, Roger</au><au>Maya, Michelle</au><au>Nunez, Emmanuel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1987-11-13</date><risdate>1987</risdate><volume>148</volume><issue>3</issue><spage>1165</spage><epage>1173</epage><pages>1165-1173</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>We report evidence based on equilibrium binding, electrophoretic, autoradiographic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). We show that in the sera of postnatal developing animals, the thyroxine and the triiodothyronine binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TßG.
In the adult serum, the TBG persists in decreased amounts : it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2446606</pmid><doi>10.1016/S0006-291X(87)80255-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1987-11, Vol.148 (3), p.1165-1173 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Age Factors alpha-Fetoproteins - metabolism Animals Applied sciences Exact sciences and technology Other techniques and industries Prealbumin - metabolism proteins Rats Thyroxine - metabolism thyroxine-binding globulin Thyroxine-Binding Proteins - metabolism Triiodothyronine - metabolism |
| title | A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats |
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