Dose-Effect and Kinetic-Dynamic Relationships of the (β-Adrenoceptor Blocking Properties of Various Doses of Talinolol in Healthy Humans

Twelve healthy subjects were investigated on six separate occasions at least 1 week apart when they either received a single oral dose of 80 mg propranolol; 25, 50, 100, or 400 mg talinolol; or placebo (double-blinded, period-balanced six-way cross-over design). The subjects were investigated during...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1995-12, Vol.26 (6), p.879-888
Hauptverfasser:	de Mey, Christian, Schroeter, V, Butzer, R, Jahn, P, Weisser, K, Wetterich, U, Terhaag, B, Mutschler, E, Spahn-Langguth, H, Palm, D, Belz, G G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Adult Blood Pressure - drug effects Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Epinephrine - pharmacology Heart Rate - drug effects Humans Isoproterenol - pharmacology Male Propanolamines - pharmacokinetics Propanolamines - pharmacology Receptors, Adrenergic, beta-1 - analysis Stereoisomerism
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