A protective role for testosterone in adjuvant-induced arthritis

We have investigated the role of the gonadal steroids testosterone (T) and progesterone in modulating: (1) the onset and severity of adjuvant-induced arthritis (AA), (2) the response of the hypothalamo-pituitary-adrenal (HPA) axis, and (3) the levels of plasma prolactin and anterior pituitary prolac...

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Veröffentlicht in:	British journal of rheumatology 1995-12, Vol.34 (12), p.1117-1122
Hauptverfasser:	HARBUZ, M. S, PERVEEN-GILL, Z, LIGHTMAN, S. L, JESSOP, D. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Arthritis, Experimental - metabolism Arthritis, Experimental - physiopathology Arthritis, Experimental - prevention & control Biological and medical sciences Corticosterone - blood Corticotropin-Releasing Hormone - genetics Diseases of the osteoarticular system Hypothalamo-Hypophyseal System - physiopathology In Situ Hybridization Inflammatory joint diseases Male Medical sciences Orchiectomy Pituitary Gland, Anterior - metabolism Pituitary-Adrenal System - physiopathology Pro-Opiomelanocortin - genetics Progesterone - administration & dosage Progesterone - physiology Prolactin - blood Prolactin - genetics Radioimmunoassay Rats Rats, Inbred Strains RNA, Messenger - metabolism Testosterone - blood Testosterone - pharmacology Testosterone - physiology
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