Response of newborn and adult sheep to pyrogens: relation between fever and brain eicosanoid changes

We investigated whether the weak febrile response to pyrogens in newborns is due to a diminished activation of the putative pyrogen mediator, prostaglandin (PG)E 2. Indwelling cannulas in the third ventricle of lambs (age, 5–31 days) and adult ewes were used to collect cerebrospinal fluid (CSF) for...

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Veröffentlicht in:	Brain research 1995-11, Vol.700 (1), p.191-204
Hauptverfasser:	Coceani, Flavio, Bishai, Isis, Engelberts, Doreen, House, Robert V., Adamson, S. Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Basal Metabolism Biological and medical sciences Blood-brain barrier Brain - drug effects Brain - growth & development Brain - metabolism Cytokines - biosynthesis Dinoprostone - biosynthesis Eicosanoids - cerebrospinal fluid Eicosanoids - metabolism Endotoxins - pharmacology Female Fever - chemically induced Fever - metabolism Fever mechanism Fundamental and applied biological sciences. Psychology Injections, Intravenous Injections, Intraventricular Leukotriene Male Neonate Organum vasculosum laminae terminalis Platelet activating factor Platelet Activating Factor - pharmacology Prostaglandin Pyrogen Sheep Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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