Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease
In this study we investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the molecular forms of these enzymes in the cerebrospinal fluid (CSF) of non-demented and demented Parkinsonian patients and in controls. The ratio of AChE to BChE activity was lower in the CSF...
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| Veröffentlicht in: | Journal of the neurological sciences 1987-11, Vol.81 (2), p.273-279 |
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| container_issue | 2 |
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| container_title | Journal of the neurological sciences |
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| creator | Sirviö, Jouni Soininen, Hilkka S. Kutvonen, Raija Hyttinen, Juha-Matti Helkala, Eeva-Liisa Riekkinen, Paavo J. |
| description | In this study we investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the molecular forms of these enzymes in the cerebrospinal fluid (CSF) of non-demented and demented Parkinsonian patients and in controls. The ratio of AChE to BChE activity was lower in the CSF of demented patients than in non-demented patients, although AChE and BChE activities and the molecular forms of AChE and BChE were the same in the different groups of patients. AChE activity in CSF did not vary according to the severity or duration of dementia associated with Parkinson's disease or with the disability stage of Parkinson's disease. BChE activity in CSF correlated with these clinical parameters, and patients with cerebral atrophy had higher BChE activity in CSF than those patients without atrophy. These alterations in the BChE activity of CSF may be related to gliosis which occurs in the degenerating brain tissue. |
| doi_str_mv | 10.1016/0022-510X(87)90102-X |
| format | Article |
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The ratio of AChE to BChE activity was lower in the CSF of demented patients than in non-demented patients, although AChE and BChE activities and the molecular forms of AChE and BChE were the same in the different groups of patients. AChE activity in CSF did not vary according to the severity or duration of dementia associated with Parkinson's disease or with the disability stage of Parkinson's disease. BChE activity in CSF correlated with these clinical parameters, and patients with cerebral atrophy had higher BChE activity in CSF than those patients without atrophy. These alterations in the BChE activity of CSF may be related to gliosis which occurs in the degenerating brain tissue.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(87)90102-X</identifier><identifier>PMID: 3694232</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acetylcholinesterase ; Acetylcholinesterase - cerebrospinal fluid ; Adult ; Age Factors ; Aged ; Biological and medical sciences ; Butyrylcholinesterase ; Butyrylcholinesterase - cerebrospinal fluid ; Cerebrospinal fluid ; Cholinesterases - cerebrospinal fluid ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - cerebrospinal fluid ; Dementia - enzymology ; Dementia - etiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Molecular Conformation ; Neurology ; Parkinson Disease - cerebrospinal fluid ; Parkinson Disease - complications ; Parkinson Disease - enzymology ; Parkinson's disease</subject><ispartof>Journal of the neurological sciences, 1987-11, Vol.81 (2), p.273-279</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-648bbe8ae64145bfe7c443413ca78aa799a2e6199557313b9edcf3133409a6553</citedby><cites>FETCH-LOGICAL-c301t-648bbe8ae64145bfe7c443413ca78aa799a2e6199557313b9edcf3133409a6553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X8790102X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7489147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3694232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sirviö, Jouni</creatorcontrib><creatorcontrib>Soininen, Hilkka S.</creatorcontrib><creatorcontrib>Kutvonen, Raija</creatorcontrib><creatorcontrib>Hyttinen, Juha-Matti</creatorcontrib><creatorcontrib>Helkala, Eeva-Liisa</creatorcontrib><creatorcontrib>Riekkinen, Paavo J.</creatorcontrib><title>Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>In this study we investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the molecular forms of these enzymes in the cerebrospinal fluid (CSF) of non-demented and demented Parkinsonian patients and in controls. The ratio of AChE to BChE activity was lower in the CSF of demented patients than in non-demented patients, although AChE and BChE activities and the molecular forms of AChE and BChE were the same in the different groups of patients. AChE activity in CSF did not vary according to the severity or duration of dementia associated with Parkinson's disease or with the disability stage of Parkinson's disease. BChE activity in CSF correlated with these clinical parameters, and patients with cerebral atrophy had higher BChE activity in CSF than those patients without atrophy. These alterations in the BChE activity of CSF may be related to gliosis which occurs in the degenerating brain tissue.</description><subject>Acetylcholinesterase</subject><subject>Acetylcholinesterase - cerebrospinal fluid</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Butyrylcholinesterase</subject><subject>Butyrylcholinesterase - cerebrospinal fluid</subject><subject>Cerebrospinal fluid</subject><subject>Cholinesterases - cerebrospinal fluid</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Dementia - cerebrospinal fluid</subject><subject>Dementia - enzymology</subject><subject>Dementia - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Conformation</subject><subject>Neurology</subject><subject>Parkinson Disease - cerebrospinal fluid</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - enzymology</subject><subject>Parkinson's disease</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo6-zqP1DIQVw9tCaddD4uwrL4sbCwHhTmFtLpaiZrJj0m6V3632_GGeboqQrqqZeqB6E3lHyihIrPhLRt01Gy_qDkR00oaZv1M7SiSqqmU4o9R6sT8hKd53xPCBFK6TN0xoTmLWtX6P7KQVlCg20ccD-XJS3BbabgI-QCyWbA1hX_4MuCfcRlA9hBgj5NeeejDXgMsx_wNOKdLR5iyfjRlw3-adMfH_MULzMefIYa9Aq9GG3I8PpYL9Dvb19_Xf9obu--31xf3TaOEVoawVXfg7IgOOVdP4J0nDNOmbNSWSu1ti0IqnXXSUZZr2FwY20YJ9qKrmMX6P0hd5emv3N9w2x9dhCCjTDN2UipBBeCVpAfQFe_yQlGs0t-a9NiKDF7xWbvz-z9GSXNP8VmXdfeHvPnfgvDaenotM7fHec2OxvGZKPz-YRJrjTlsmJfDhhUFw8eksmuCnQw-ASumGHy_7_jCWnsmWQ</recordid><startdate>198711</startdate><enddate>198711</enddate><creator>Sirviö, Jouni</creator><creator>Soininen, Hilkka S.</creator><creator>Kutvonen, Raija</creator><creator>Hyttinen, Juha-Matti</creator><creator>Helkala, Eeva-Liisa</creator><creator>Riekkinen, Paavo J.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198711</creationdate><title>Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease</title><author>Sirviö, Jouni ; Soininen, Hilkka S. ; Kutvonen, Raija ; Hyttinen, Juha-Matti ; Helkala, Eeva-Liisa ; Riekkinen, Paavo J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-648bbe8ae64145bfe7c443413ca78aa799a2e6199557313b9edcf3133409a6553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acetylcholinesterase</topic><topic>Acetylcholinesterase - cerebrospinal fluid</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Butyrylcholinesterase</topic><topic>Butyrylcholinesterase - cerebrospinal fluid</topic><topic>Cerebrospinal fluid</topic><topic>Cholinesterases - cerebrospinal fluid</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Dementia - cerebrospinal fluid</topic><topic>Dementia - enzymology</topic><topic>Dementia - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Conformation</topic><topic>Neurology</topic><topic>Parkinson Disease - cerebrospinal fluid</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - enzymology</topic><topic>Parkinson's disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirviö, Jouni</creatorcontrib><creatorcontrib>Soininen, Hilkka S.</creatorcontrib><creatorcontrib>Kutvonen, Raija</creatorcontrib><creatorcontrib>Hyttinen, Juha-Matti</creatorcontrib><creatorcontrib>Helkala, Eeva-Liisa</creatorcontrib><creatorcontrib>Riekkinen, Paavo J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sirviö, Jouni</au><au>Soininen, Hilkka S.</au><au>Kutvonen, Raija</au><au>Hyttinen, Juha-Matti</au><au>Helkala, Eeva-Liisa</au><au>Riekkinen, Paavo J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1987-11</date><risdate>1987</risdate><volume>81</volume><issue>2</issue><spage>273</spage><epage>279</epage><pages>273-279</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>In this study we investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the molecular forms of these enzymes in the cerebrospinal fluid (CSF) of non-demented and demented Parkinsonian patients and in controls. The ratio of AChE to BChE activity was lower in the CSF of demented patients than in non-demented patients, although AChE and BChE activities and the molecular forms of AChE and BChE were the same in the different groups of patients. AChE activity in CSF did not vary according to the severity or duration of dementia associated with Parkinson's disease or with the disability stage of Parkinson's disease. BChE activity in CSF correlated with these clinical parameters, and patients with cerebral atrophy had higher BChE activity in CSF than those patients without atrophy. These alterations in the BChE activity of CSF may be related to gliosis which occurs in the degenerating brain tissue.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>3694232</pmid><doi>10.1016/0022-510X(87)90102-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1987-11, Vol.81 (2), p.273-279 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase Acetylcholinesterase - cerebrospinal fluid Adult Age Factors Aged Biological and medical sciences Butyrylcholinesterase Butyrylcholinesterase - cerebrospinal fluid Cerebrospinal fluid Cholinesterases - cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - cerebrospinal fluid Dementia - enzymology Dementia - etiology Female Humans Male Medical sciences Middle Aged Molecular Conformation Neurology Parkinson Disease - cerebrospinal fluid Parkinson Disease - complications Parkinson Disease - enzymology Parkinson's disease |
| title | Acetyl- and butyrylcholinesterase activity in the cerebrospinal fluid of patients with Parkinson's disease |
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