Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin cofactor II

Heparin cofactor II (HC II) and thrombin were chemically modified with pyridoxal 5′-phosphate, and their effects on the inhibition of thrombin by HC II in the presence of heparin or dermatan sulfate were studied. The inhibition of thrombin by HC II was enhanced about 7000-fold in the presence of hep...

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Veröffentlicht in:	FEBS letters 1987-12, Vol.225 (1), p.109-112
Hauptverfasser:	Yamagishi, Ryoichi, Koide, Takehiko, Sakuragawa, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombins Biological and medical sciences Blood coagulation. Blood cells Chemical Phenomena Chemistry Chondroitin - analogs & derivatives Dermatan Sulfate - metabolism Dermatan Sulfate - pharmacology Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Glycoproteins - pharmacology Heparin Heparin - metabolism Heparin - pharmacology Heparin Cofactor II Humans Molecular and cellular biology Pyridoxal 5′-phosphate Pyridoxal Phosphate Ternary model Thrombin Thrombin - antagonists & inhibitors Thrombin - metabolism
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