Comparison of Growth Hormone-Releasing Factor and Somatotropin: The Somatotropic Axis In Lactating Primiparous Cows
Our objective was to compare the effects of recombinant bovine growth hormone-releasing factor and recombinant bST on the somatotropic cascade in lactating dairy cows. Primiparous cows were killed after 63 d of continuous daily infusion with 12 mg of releasing factor or 29 mg of bST or no infusion (...
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| Veröffentlicht in: | Journal of dairy science 1995-10, Vol.78 (10), p.2140-2149 |
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| container_title | Journal of dairy science |
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| creator | Vanderkooi, W. K Vandehaar, M. J Sharma, B. K Binelli, M Tucker, H. A Akers, R. M Moseley, W. M |
| description | Our objective was to compare the effects of recombinant bovine growth hormone-releasing factor and recombinant bST on the somatotropic cascade in lactating dairy cows. Primiparous cows were killed after 63 d of continuous daily infusion with 12 mg of releasing factor or 29 mg of bST or no infusion (controls). Both hormone infusions similarly increased mean concentration of somatotropin in serum, but pulsatility of somatotropin in serum was greater for cows given releasing factor. Both hormone infusions increased the amounts of IGF-I in serum, IGF-I mRNA in liver, and IGF-binding protein-3 in serum and decreased IGF binding protein-2 in serum, but these effects were less for cows given releasing factor than for those given bST. Both infusions decreased the number of free binding sites for IGF-I in mammary tissue. In liver, treatment did not alter the abundance of mRNA for the somatotropin receptor or the number of free binding sites for somatotropin. Results suggest that endogenous somatotropin is less effective as an IGF-I secretagogue than is exogenous bST infused continuously, yet the releasing factor and bST increased milk yield similarly. We conclude that growth hormone-releasing factor stimulates milk synthesis mostly through the same mechanisms as bST, but that serum IGF-I alone is not a good indicator of the galactopoietic potency of the two hormones. |
| doi_str_mv | 10.3168/jds.S0022-0302(95)76841-2 |
| format | Article |
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K ; Vandehaar, M. J ; Sharma, B. K ; Binelli, M ; Tucker, H. A ; Akers, R. M ; Moseley, W. M</creator><creatorcontrib>Vanderkooi, W. K ; Vandehaar, M. J ; Sharma, B. K ; Binelli, M ; Tucker, H. A ; Akers, R. M ; Moseley, W. M</creatorcontrib><description>Our objective was to compare the effects of recombinant bovine growth hormone-releasing factor and recombinant bST on the somatotropic cascade in lactating dairy cows. Primiparous cows were killed after 63 d of continuous daily infusion with 12 mg of releasing factor or 29 mg of bST or no infusion (controls). Both hormone infusions similarly increased mean concentration of somatotropin in serum, but pulsatility of somatotropin in serum was greater for cows given releasing factor. Both hormone infusions increased the amounts of IGF-I in serum, IGF-I mRNA in liver, and IGF-binding protein-3 in serum and decreased IGF binding protein-2 in serum, but these effects were less for cows given releasing factor than for those given bST. Both infusions decreased the number of free binding sites for IGF-I in mammary tissue. In liver, treatment did not alter the abundance of mRNA for the somatotropin receptor or the number of free binding sites for somatotropin. Results suggest that endogenous somatotropin is less effective as an IGF-I secretagogue than is exogenous bST infused continuously, yet the releasing factor and bST increased milk yield similarly. We conclude that growth hormone-releasing factor stimulates milk synthesis mostly through the same mechanisms as bST, but that serum IGF-I alone is not a good indicator of the galactopoietic potency of the two hormones.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(95)76841-2</identifier><identifier>PMID: 8598398</identifier><language>eng</language><publisher>United States: Am Dairy Sci Assoc</publisher><subject>Animals ; Cattle - metabolism ; Female ; Growth Hormone - blood ; Growth Hormone - pharmacology ; Growth Hormone-Releasing Hormone - pharmacology ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Lactation ; Liver - metabolism ; Periodicity ; Recombinant Proteins - pharmacology ; RNA, Messenger - metabolism</subject><ispartof>Journal of dairy science, 1995-10, Vol.78 (10), p.2140-2149</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-6d98535e2468af5d5228e925273cb40732c867920a35de6db89dbe63719eac2f3</citedby><cites>FETCH-LOGICAL-c423t-6d98535e2468af5d5228e925273cb40732c867920a35de6db89dbe63719eac2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27869,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8598398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanderkooi, W. 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We conclude that growth hormone-releasing factor stimulates milk synthesis mostly through the same mechanisms as bST, but that serum IGF-I alone is not a good indicator of the galactopoietic potency of the two hormones.</description><subject>Animals</subject><subject>Cattle - metabolism</subject><subject>Female</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - pharmacology</subject><subject>Growth Hormone-Releasing Hormone - pharmacology</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Lactation</subject><subject>Liver - metabolism</subject><subject>Periodicity</subject><subject>Recombinant Proteins - pharmacology</subject><subject>RNA, Messenger - metabolism</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkVtPGzEQha2qiAbKT6jkqhKUhwV7vL7xhqJykSJRcXm2nF0vcbS7DvZGgX9fL4lQxZNlz3fmzPgg9JOSM0aFOl_W6eyBEICCMAK_NT-VQpW0gC9oQjnwglGtvqLJB_INHaS0zFcKhO-jfcW1YlpNUJqGbmWjT6HHocHXMWyGBb4JsQu9K-5d62zy_TO-stUQIrZ9jR9CZ4cwxLDy_QV-XLj_Xyp8-eoTvu3xLCvsMGr_Rt_5bBLWCU_DJn1He41tkzvanYfo6erP4_SmmN1d304vZ0VVAhsKUWvFGXdQCmUbXnMA5TRwkKyal0QyqJSQGohlvHainitdz51gkmpnK2jYITre9l3F8LJ2aTCdT5VrW9u7PIuRUglQpcrgr0_gMqxjn2czVElJpAAtMqW3VBVDStE1ZpUXs_HNUGLGWEyOxbzHYsY_N5qb91gMZO2PncN63rn6Q7nLIddPtvWFf15sfHQmdbZtM03HrlKNHkBLwv4ByAuXhg</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Vanderkooi, W. 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Both hormone infusions similarly increased mean concentration of somatotropin in serum, but pulsatility of somatotropin in serum was greater for cows given releasing factor. Both hormone infusions increased the amounts of IGF-I in serum, IGF-I mRNA in liver, and IGF-binding protein-3 in serum and decreased IGF binding protein-2 in serum, but these effects were less for cows given releasing factor than for those given bST. Both infusions decreased the number of free binding sites for IGF-I in mammary tissue. In liver, treatment did not alter the abundance of mRNA for the somatotropin receptor or the number of free binding sites for somatotropin. Results suggest that endogenous somatotropin is less effective as an IGF-I secretagogue than is exogenous bST infused continuously, yet the releasing factor and bST increased milk yield similarly. We conclude that growth hormone-releasing factor stimulates milk synthesis mostly through the same mechanisms as bST, but that serum IGF-I alone is not a good indicator of the galactopoietic potency of the two hormones.</abstract><cop>United States</cop><pub>Am Dairy Sci Assoc</pub><pmid>8598398</pmid><doi>10.3168/jds.S0022-0302(95)76841-2</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dairy science, 1995-10, Vol.78 (10), p.2140-2149 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Periodicals Index Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cattle - metabolism Female Growth Hormone - blood Growth Hormone - pharmacology Growth Hormone-Releasing Hormone - pharmacology Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Lactation Liver - metabolism Periodicity Recombinant Proteins - pharmacology RNA, Messenger - metabolism |
| title | Comparison of Growth Hormone-Releasing Factor and Somatotropin: The Somatotropic Axis In Lactating Primiparous Cows |
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