2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca2+ sequestration

Treatment of rat liver microsomes with 2,5‐di(tert‐butyl)‐1,4‐benzohydroquinone caused a dose‐related inhibition (K i⋍1 μM) of ATP‐dependent Ca2+ sequestration. This was paralleled by a similar impairment of the microsomal Ca2+ ‐stimulated ATPase activity. In contrast, the hydroquinone failed to ind...

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Veröffentlicht in:	FEBS letters 1987-11, Vol.224 (2), p.331-336
Hauptverfasser:	Moore, Gregory A., McConkey, David J., Kass, Georges E.N., O'Brien, Peter J., Orrenius, Sten
Format:	Artikel
Sprache:	eng
Schlagworte:	(Ca2+ + Mg2+)-ATPase 2,5-Di(tert-butyl)-1,4-benzohydroquinone Animals Biological and medical sciences Ca2+ sequestration Calcium - metabolism Calcium-Transporting ATPases - metabolism Cell Compartmentation - drug effects Cell Membrane - enzymology Cytochrome P-450 Enzyme System - metabolism General and cellular metabolism. Vitamins Hydroquinones - pharmacology In Vitro Techniques Male Medical sciences Microsome Microsomes, Liver - drug effects Microsomes, Liver - metabolism Mitochondria, Liver - metabolism Pharmacology. Drug treatments Rat liver Rats
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