ROLE OF INTRACELLULAR SIGNALLING PATHWAYS IN HYDROGEN PEROXIDE-INDUCED INJURY TO RAT GLOMERULAR MESANGIAL CELLS

SUMMARY 1. Brief exposure of cultured rat glomerular mesangial cells (GMC) to H202 in nominally bicarbonate‐free solution induced a rapid dose dependent, dantrolene‐inhibitable increase in intracellular free Ca2+ from 65 ± 6 to 203 ± 14 nmol/L and a prolonged release of [14C]‐arachidonic acid [14C]‐...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1995-12, Vol.22 (12), p.924-933
Hauptverfasser:	Shaw, Sidney, Naegeli, Patricia, Etter, Jean-Daniel, Weidmann, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arachidonic acid Arachidonic Acid - metabolism calcium Calcium - metabolism Cells, Cultured hydrogen peroxide Hydrogen Peroxide - pharmacology Kidney Glomerulus - drug effects lipoxygenases mesangial cells Quinacrine - pharmacology Rats Rats, Wistar reactive oxygen metabolites Signal Transduction - drug effects signalling pathways Time Factors
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