Targeting peptide nucleic acid-protein conjugates to structural features within duplex DNA

A convenient small scale synthesis has been developed for obtaining peptide nucleic acid oligomers (PNAs). PNAs have been conjugated to a protein, staphylococcal nuclease, through disulfide exchange between a cysteine at the 3′-(carboxy) end of the PNA and an introduced cysteine on the surface of th...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1995-04, Vol.3 (4), p.437-445
Hauptverfasser:	Norton, James C., Waggenspack, John H., Varnum, Elana, Corey, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence In Situ Hybridization Micrococcal Nuclease - chemistry Micrococcal Nuclease - metabolism Molecular Sequence Data Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism Nucleic Acids - chemical synthesis Nucleic Acids - isolation & purification Peptides - chemical synthesis Peptides - isolation & purification Peptides - metabolism Plasmids - metabolism Staphylococcus - enzymology
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