Changes in an HER-2 peptide upregulating HLA-A2 expression affect both conformational epitopes and CTL recognition : Implications for optimization of antigen presentation and tumor-specific CTL induction

The HER-2/neu protooncogene (HER-2) is overexpressed in a significant number of breast and ovarian tumors. Peptides of HER-2 sequence were recently found to reconstitute recognition of cytotoxic T lymphocytes (CTLs) from tumor-associated (TALs) and tumor-infiltrating (TILs) lymphocytes, indicating t...

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Veröffentlicht in:	Journal of immunotherapy 1995-11, Vol.18 (4), p.197-209
Hauptverfasser:	FISK, B, SAVARY, C, HUDSON, J. M, O'BRIAN, C. A, MURRAY, J. L, WHARTON, J. T, IOANNIDES, C. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - chemistry Antigen Presentation - drug effects Biological and medical sciences Cytotoxicity, Immunologic - drug effects Epitopes - chemistry Epitopes - drug effects Epitopes - immunology HLA-A2 Antigen - drug effects HLA-A2 Antigen - metabolism Host-tumor relations. Immunology. Biological markers Humans Lymphocyte Activation - drug effects Medical sciences Molecular Sequence Data Oligopeptides - chemistry Oligopeptides - immunology Oligopeptides - pharmacology Protein Conformation - drug effects Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - immunology Receptor, ErbB-2 - pharmacology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tumors Up-Regulation - drug effects Up-Regulation - immunology
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