Self-stimulation of the MFB following parabrachial lesions
It has been reported previously that the parabrachial region supports robust self-stimulation. In the present study, we determined whether lesions of the parabrachial nucleus (PBN) influence the rewarding effect of medial forebrain bundle (MFB) stimulation. In 10 rats, stimulation electrodes were ai...
Gespeichert in:
| Veröffentlicht in: | Physiology & behavior 1995-09, Vol.58 (3), p.559-566 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 566 |
|---|---|
| container_issue | 3 |
| container_start_page | 559 |
| container_title | Physiology & behavior |
| container_volume | 58 |
| creator | Waraczynski, Meg Shizgal, Peter |
| description | It has been reported previously that the parabrachial region supports robust self-stimulation. In the present study, we determined whether lesions of the parabrachial nucleus (PBN) influence the rewarding effect of medial forebrain bundle (MFB) stimulation. In 10 rats, stimulation electrodes were aimed at the lateral hypothalamus and/or ventral tegmental area and a lesioning electrode aimed at the PBN. Rate-frequency curves were collected at each of three stimulation currents at each electrode, before and after lesioning. Four rats showed virtually no change in the frequency required to sustain half-maximal performance following lesioning, and two showed some postlesion decreases. Only two rats showed substantial postlesion increases in required frequency; the lesions in these subjects damaged the region ventral to the superior cerebellar peduncle, just caudal to the decussation of the peduncle, but spared the PBN. Thus, the reward effectiveness of MFB stimulation does not appear to be altered substantially following PBN lesions but may decrease following damage to the neighboring pedunculopontine region. |
| doi_str_mv | 10.1016/0031-9384(95)00092-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77855619</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>003193849500092W</els_id><sourcerecordid>77855619</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-753d59823818f8a20b4d77b0cefa7ae383a565e8a086db1a4350ffef6a3d38643</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMouq7-A4UeRPRQTTZNk3oQVPwCxYOK3sI0nWgk265JV_Hfm3WXPXqawzzvO8NDyA6jR4yy8phSzvKKq-KgEoeU0mqUv6yQAVOS54LK11UyWCIbZDPGjwRRXvB1sq6EklUpBuTkEb3NY-_GUw-969qss1n_jtn91XlmO--7b9e-ZRMIUAcw7w585jEmMG6RNQs-4vZiDsnz1eXTxU1-93B9e3F2lxuuyj6XgjeiUiOumLIKRrQuGilratCCBOSKgygFKqCqbGoGBRfUWrQl8CYVFHxI9ue9k9B9TjH2euyiQe-hxW4atZRKiJJVCSzmoAldjAGtngQ3hvCjGdUzZXrmQ8986EroP2X6JcV2F_3TeozNMrRwlPZ7iz1EA94GaI2LS4yXI5HuJ-x0jmFy8eUw6GgctgYbF9D0uunc_3_8Alb4hvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77855619</pqid></control><display><type>article</type><title>Self-stimulation of the MFB following parabrachial lesions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Waraczynski, Meg ; Shizgal, Peter</creator><creatorcontrib>Waraczynski, Meg ; Shizgal, Peter</creatorcontrib><description>It has been reported previously that the parabrachial region supports robust self-stimulation. In the present study, we determined whether lesions of the parabrachial nucleus (PBN) influence the rewarding effect of medial forebrain bundle (MFB) stimulation. In 10 rats, stimulation electrodes were aimed at the lateral hypothalamus and/or ventral tegmental area and a lesioning electrode aimed at the PBN. Rate-frequency curves were collected at each of three stimulation currents at each electrode, before and after lesioning. Four rats showed virtually no change in the frequency required to sustain half-maximal performance following lesioning, and two showed some postlesion decreases. Only two rats showed substantial postlesion increases in required frequency; the lesions in these subjects damaged the region ventral to the superior cerebellar peduncle, just caudal to the decussation of the peduncle, but spared the PBN. Thus, the reward effectiveness of MFB stimulation does not appear to be altered substantially following PBN lesions but may decrease following damage to the neighboring pedunculopontine region.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(95)00092-W</identifier><identifier>PMID: 8587965</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Anatomical correlates of behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Mapping ; Brain stimulation reward ; Dominance, Cerebral - physiology ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Hypothalamic Area, Lateral - physiology ; Lateral hypothalamus ; Lesions ; Male ; Medial forebrain bundle ; Medial Forebrain Bundle - physiology ; Motivation ; Neural Pathways - physiology ; Parabrachial nucleus ; Pons - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Self Stimulation - physiology ; Self-stimulation ; Tegmentum Mesencephali - physiology ; Ventral tegmental area</subject><ispartof>Physiology & behavior, 1995-09, Vol.58 (3), p.559-566</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-753d59823818f8a20b4d77b0cefa7ae383a565e8a086db1a4350ffef6a3d38643</citedby><cites>FETCH-LOGICAL-c386t-753d59823818f8a20b4d77b0cefa7ae383a565e8a086db1a4350ffef6a3d38643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0031-9384(95)00092-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3625556$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8587965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waraczynski, Meg</creatorcontrib><creatorcontrib>Shizgal, Peter</creatorcontrib><title>Self-stimulation of the MFB following parabrachial lesions</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>It has been reported previously that the parabrachial region supports robust self-stimulation. In the present study, we determined whether lesions of the parabrachial nucleus (PBN) influence the rewarding effect of medial forebrain bundle (MFB) stimulation. In 10 rats, stimulation electrodes were aimed at the lateral hypothalamus and/or ventral tegmental area and a lesioning electrode aimed at the PBN. Rate-frequency curves were collected at each of three stimulation currents at each electrode, before and after lesioning. Four rats showed virtually no change in the frequency required to sustain half-maximal performance following lesioning, and two showed some postlesion decreases. Only two rats showed substantial postlesion increases in required frequency; the lesions in these subjects damaged the region ventral to the superior cerebellar peduncle, just caudal to the decussation of the peduncle, but spared the PBN. Thus, the reward effectiveness of MFB stimulation does not appear to be altered substantially following PBN lesions but may decrease following damage to the neighboring pedunculopontine region.</description><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Brain stimulation reward</subject><subject>Dominance, Cerebral - physiology</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamic Area, Lateral - physiology</subject><subject>Lateral hypothalamus</subject><subject>Lesions</subject><subject>Male</subject><subject>Medial forebrain bundle</subject><subject>Medial Forebrain Bundle - physiology</subject><subject>Motivation</subject><subject>Neural Pathways - physiology</subject><subject>Parabrachial nucleus</subject><subject>Pons - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Self Stimulation - physiology</subject><subject>Self-stimulation</subject><subject>Tegmentum Mesencephali - physiology</subject><subject>Ventral tegmental area</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4UeRPRQTTZNk3oQVPwCxYOK3sI0nWgk265JV_Hfm3WXPXqawzzvO8NDyA6jR4yy8phSzvKKq-KgEoeU0mqUv6yQAVOS54LK11UyWCIbZDPGjwRRXvB1sq6EklUpBuTkEb3NY-_GUw-969qss1n_jtn91XlmO--7b9e-ZRMIUAcw7w585jEmMG6RNQs-4vZiDsnz1eXTxU1-93B9e3F2lxuuyj6XgjeiUiOumLIKRrQuGilratCCBOSKgygFKqCqbGoGBRfUWrQl8CYVFHxI9ue9k9B9TjH2euyiQe-hxW4atZRKiJJVCSzmoAldjAGtngQ3hvCjGdUzZXrmQ8986EroP2X6JcV2F_3TeozNMrRwlPZ7iz1EA94GaI2LS4yXI5HuJ-x0jmFy8eUw6GgctgYbF9D0uunc_3_8Alb4hvQ</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Waraczynski, Meg</creator><creator>Shizgal, Peter</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Self-stimulation of the MFB following parabrachial lesions</title><author>Waraczynski, Meg ; Shizgal, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-753d59823818f8a20b4d77b0cefa7ae383a565e8a086db1a4350ffef6a3d38643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Brain stimulation reward</topic><topic>Dominance, Cerebral - physiology</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamic Area, Lateral - physiology</topic><topic>Lateral hypothalamus</topic><topic>Lesions</topic><topic>Male</topic><topic>Medial forebrain bundle</topic><topic>Medial Forebrain Bundle - physiology</topic><topic>Motivation</topic><topic>Neural Pathways - physiology</topic><topic>Parabrachial nucleus</topic><topic>Pons - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Self Stimulation - physiology</topic><topic>Self-stimulation</topic><topic>Tegmentum Mesencephali - physiology</topic><topic>Ventral tegmental area</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waraczynski, Meg</creatorcontrib><creatorcontrib>Shizgal, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waraczynski, Meg</au><au>Shizgal, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-stimulation of the MFB following parabrachial lesions</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>58</volume><issue>3</issue><spage>559</spage><epage>566</epage><pages>559-566</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>It has been reported previously that the parabrachial region supports robust self-stimulation. In the present study, we determined whether lesions of the parabrachial nucleus (PBN) influence the rewarding effect of medial forebrain bundle (MFB) stimulation. In 10 rats, stimulation electrodes were aimed at the lateral hypothalamus and/or ventral tegmental area and a lesioning electrode aimed at the PBN. Rate-frequency curves were collected at each of three stimulation currents at each electrode, before and after lesioning. Four rats showed virtually no change in the frequency required to sustain half-maximal performance following lesioning, and two showed some postlesion decreases. Only two rats showed substantial postlesion increases in required frequency; the lesions in these subjects damaged the region ventral to the superior cerebellar peduncle, just caudal to the decussation of the peduncle, but spared the PBN. Thus, the reward effectiveness of MFB stimulation does not appear to be altered substantially following PBN lesions but may decrease following damage to the neighboring pedunculopontine region.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8587965</pmid><doi>10.1016/0031-9384(95)00092-W</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 1995-09, Vol.58 (3), p.559-566 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77855619 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Brain Mapping Brain stimulation reward Dominance, Cerebral - physiology Electric Stimulation Fundamental and applied biological sciences. Psychology Hypothalamic Area, Lateral - physiology Lateral hypothalamus Lesions Male Medial forebrain bundle Medial Forebrain Bundle - physiology Motivation Neural Pathways - physiology Parabrachial nucleus Pons - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Self Stimulation - physiology Self-stimulation Tegmentum Mesencephali - physiology Ventral tegmental area |
| title | Self-stimulation of the MFB following parabrachial lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A24%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Self-stimulation%20of%20the%20MFB%20following%20parabrachial%20lesions&rft.jtitle=Physiology%20&%20behavior&rft.au=Waraczynski,%20Meg&rft.date=1995-09-01&rft.volume=58&rft.issue=3&rft.spage=559&rft.epage=566&rft.pages=559-566&rft.issn=0031-9384&rft.eissn=1873-507X&rft_id=info:doi/10.1016/0031-9384(95)00092-W&rft_dat=%3Cproquest_cross%3E77855619%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77855619&rft_id=info:pmid/8587965&rft_els_id=003193849500092W&rfr_iscdi=true |