Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on hepatic cholesterol 7α-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation
The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7α-hyroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuou...
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| Veröffentlicht in: | Atherosclerosis 1994-12, Vol.111 (2), p.183-189 |
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| container_title | Atherosclerosis |
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| creator | Hayashi, Kozo Noshiro, Mitsuhide Kurushima, Hitoshi Kuga, Yoshio Nomura, Syu-ichi Ohkura, Yoshifumi Ohtani, Harumi Kurokawa, Jun-ichi Tanaka, Kouichi Yasunobu, Yuji Kambe, Masayuki Kajiyama, Goro |
| description | The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7α-hyroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuous administration of pravastatin induced no significant changes in hepatic cholesterol content, ACAT and cholesterol 7α-hydroxylase activities, or bile lipid and acid composition. Abrupt withdrawal of pravastatin induced increases in hepatic cholesterol content and ACAT activity and no change in hepatic cholesterol 7α-hydroxylase activity, and increased cholesterol saturation in bile. Hepatic cholesterol 7α-hydroxylase activity paralleled hepatic mRNA levels of this enzyme. These results suggest that a change in hepatic cholesterol metabolism induced by continuous administration of pravastatin maintains a constant net balance of hepatic cholesterol content. In addition, the drug has no deleterious influence on metabolism of bile lipids and acids and related enzymes, except for a transient increase in cholesterol saturation in bile induced by an inappropriate increase in hepatic cholesterol content and a lack of response of cholesterol 7α-hydroxylase activity to changes in hepatic cholesterol content upon abrupt withdrawal of pravastatin. |
| doi_str_mv | 10.1016/0021-9150(94)90092-2 |
| format | Article |
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Continuous administration of pravastatin induced no significant changes in hepatic cholesterol content, ACAT and cholesterol 7α-hydroxylase activities, or bile lipid and acid composition. Abrupt withdrawal of pravastatin induced increases in hepatic cholesterol content and ACAT activity and no change in hepatic cholesterol 7α-hydroxylase activity, and increased cholesterol saturation in bile. Hepatic cholesterol 7α-hydroxylase activity paralleled hepatic mRNA levels of this enzyme. These results suggest that a change in hepatic cholesterol metabolism induced by continuous administration of pravastatin maintains a constant net balance of hepatic cholesterol content. In addition, the drug has no deleterious influence on metabolism of bile lipids and acids and related enzymes, except for a transient increase in cholesterol saturation in bile induced by an inappropriate increase in hepatic cholesterol content and a lack of response of cholesterol 7α-hydroxylase activity to changes in hepatic cholesterol content upon abrupt withdrawal of pravastatin.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/0021-9150(94)90092-2</identifier><identifier>PMID: 7718020</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Acyl-coenzyme A cholesterol acyltransferase ; Animals ; Bile - drug effects ; Bile - metabolism ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; Cholesterol 7-alpha-Hydroxylase - drug effects ; Cholesterol 7-alpha-Hydroxylase - metabolism ; Cholesterol 7α-hydroxylase ; Cricetinae ; General and cellular metabolism. Vitamins ; Lithogenic bile ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Male ; Medical sciences ; Mesocricetus ; Microsomes, Liver - enzymology ; mRNA ; Pharmacology. Drug treatments ; Pravastatin - pharmacology ; Sterol O-Acyltransferase - drug effects ; Sterol O-Acyltransferase - metabolism</subject><ispartof>Atherosclerosis, 1994-12, Vol.111 (2), p.183-189</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-fb884f72240363d5b704954cbdfcf2341bfe63de72a35936ffe5b04d34c87a923</citedby><cites>FETCH-LOGICAL-c388t-fb884f72240363d5b704954cbdfcf2341bfe63de72a35936ffe5b04d34c87a923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0021-9150(94)90092-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3538,27906,27907,45977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3355885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7718020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Kozo</creatorcontrib><creatorcontrib>Noshiro, Mitsuhide</creatorcontrib><creatorcontrib>Kurushima, Hitoshi</creatorcontrib><creatorcontrib>Kuga, Yoshio</creatorcontrib><creatorcontrib>Nomura, Syu-ichi</creatorcontrib><creatorcontrib>Ohkura, Yoshifumi</creatorcontrib><creatorcontrib>Ohtani, Harumi</creatorcontrib><creatorcontrib>Kurokawa, Jun-ichi</creatorcontrib><creatorcontrib>Tanaka, Kouichi</creatorcontrib><creatorcontrib>Yasunobu, Yuji</creatorcontrib><creatorcontrib>Kambe, Masayuki</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><title>Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on hepatic cholesterol 7α-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7α-hyroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuous administration of pravastatin induced no significant changes in hepatic cholesterol content, ACAT and cholesterol 7α-hydroxylase activities, or bile lipid and acid composition. Abrupt withdrawal of pravastatin induced increases in hepatic cholesterol content and ACAT activity and no change in hepatic cholesterol 7α-hydroxylase activity, and increased cholesterol saturation in bile. Hepatic cholesterol 7α-hydroxylase activity paralleled hepatic mRNA levels of this enzyme. These results suggest that a change in hepatic cholesterol metabolism induced by continuous administration of pravastatin maintains a constant net balance of hepatic cholesterol content. In addition, the drug has no deleterious influence on metabolism of bile lipids and acids and related enzymes, except for a transient increase in cholesterol saturation in bile induced by an inappropriate increase in hepatic cholesterol content and a lack of response of cholesterol 7α-hydroxylase activity to changes in hepatic cholesterol content upon abrupt withdrawal of pravastatin.</description><subject>Acyl-coenzyme A cholesterol acyltransferase</subject><subject>Animals</subject><subject>Bile - drug effects</subject><subject>Bile - metabolism</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cholesterol 7-alpha-Hydroxylase - drug effects</subject><subject>Cholesterol 7-alpha-Hydroxylase - metabolism</subject><subject>Cholesterol 7α-hydroxylase</subject><subject>Cricetinae</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Lithogenic bile</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Microsomes, Liver - enzymology</subject><subject>mRNA</subject><subject>Pharmacology. Drug treatments</subject><subject>Pravastatin - pharmacology</subject><subject>Sterol O-Acyltransferase - drug effects</subject><subject>Sterol O-Acyltransferase - metabolism</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2L1TAUDaKMz6f_QCELEYWpJk36mroQhmH8gAE3ug5pemMjaVOTdLT-K_-If8etqe9ZcOMqcO855957ThB6SMlzSujhBSElLRpakacNf9YQ0pRFeQvtqKibgnLBb6PdBrmL7sX4mRDCayrO0FmdH1KSHfp1ZQzohL3BU1A3KiaV7HiOFWZFv3TBf1sKVgyQ-sV9cnNSYXFYexi_LwNkVIBu1klFwHbsbWuTD-fYj7iHKQtprHvvICYI3uH654-_mi4z8hC9uGITu3j5D3ptpqDGaCAc0WOHW-sAOzvZDkfQAZLNs-yIUw-4V8NKxV9t6nMtqXwWjKvYtowNenZqJd1Hd4xyER6c3j36-Prqw-Xb4vr9m3eXF9eFZkKkwrRCcFOXJSfswLqqrQlvKq7bzmhTMk5bA7kOdalY1bBDNrNqCe8Y16JWTcn26MlRdwr-y5xvk4ONGpxTI_g5yroWFRMHmoH8CNTBxxjAyCnYIdstKZFr3nINU65hyobLP3nLVf_RSX9uB-g20ing3H986quolTPZUG3jBmOsqkTeYI9eHWGQvbixEGTUFkYNnQ35e8jO2__v8Ruk5c50</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Hayashi, Kozo</creator><creator>Noshiro, Mitsuhide</creator><creator>Kurushima, Hitoshi</creator><creator>Kuga, Yoshio</creator><creator>Nomura, Syu-ichi</creator><creator>Ohkura, Yoshifumi</creator><creator>Ohtani, Harumi</creator><creator>Kurokawa, Jun-ichi</creator><creator>Tanaka, Kouichi</creator><creator>Yasunobu, Yuji</creator><creator>Kambe, Masayuki</creator><creator>Kajiyama, Goro</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on hepatic cholesterol 7α-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation</title><author>Hayashi, Kozo ; Noshiro, Mitsuhide ; Kurushima, Hitoshi ; Kuga, Yoshio ; Nomura, Syu-ichi ; Ohkura, Yoshifumi ; Ohtani, Harumi ; Kurokawa, Jun-ichi ; Tanaka, Kouichi ; Yasunobu, Yuji ; Kambe, Masayuki ; Kajiyama, Goro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-fb884f72240363d5b704954cbdfcf2341bfe63de72a35936ffe5b04d34c87a923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acyl-coenzyme A cholesterol acyltransferase</topic><topic>Animals</topic><topic>Bile - drug effects</topic><topic>Bile - metabolism</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cholesterol 7-alpha-Hydroxylase - drug effects</topic><topic>Cholesterol 7-alpha-Hydroxylase - metabolism</topic><topic>Cholesterol 7α-hydroxylase</topic><topic>Cricetinae</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Lithogenic bile</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Microsomes, Liver - enzymology</topic><topic>mRNA</topic><topic>Pharmacology. Drug treatments</topic><topic>Pravastatin - pharmacology</topic><topic>Sterol O-Acyltransferase - drug effects</topic><topic>Sterol O-Acyltransferase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Kozo</creatorcontrib><creatorcontrib>Noshiro, Mitsuhide</creatorcontrib><creatorcontrib>Kurushima, Hitoshi</creatorcontrib><creatorcontrib>Kuga, Yoshio</creatorcontrib><creatorcontrib>Nomura, Syu-ichi</creatorcontrib><creatorcontrib>Ohkura, Yoshifumi</creatorcontrib><creatorcontrib>Ohtani, Harumi</creatorcontrib><creatorcontrib>Kurokawa, Jun-ichi</creatorcontrib><creatorcontrib>Tanaka, Kouichi</creatorcontrib><creatorcontrib>Yasunobu, Yuji</creatorcontrib><creatorcontrib>Kambe, Masayuki</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Kozo</au><au>Noshiro, Mitsuhide</au><au>Kurushima, Hitoshi</au><au>Kuga, Yoshio</au><au>Nomura, Syu-ichi</au><au>Ohkura, Yoshifumi</au><au>Ohtani, Harumi</au><au>Kurokawa, Jun-ichi</au><au>Tanaka, Kouichi</au><au>Yasunobu, Yuji</au><au>Kambe, Masayuki</au><au>Kajiyama, Goro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on hepatic cholesterol 7α-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>111</volume><issue>2</issue><spage>183</spage><epage>189</epage><pages>183-189</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7α-hyroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuous administration of pravastatin induced no significant changes in hepatic cholesterol content, ACAT and cholesterol 7α-hydroxylase activities, or bile lipid and acid composition. Abrupt withdrawal of pravastatin induced increases in hepatic cholesterol content and ACAT activity and no change in hepatic cholesterol 7α-hydroxylase activity, and increased cholesterol saturation in bile. Hepatic cholesterol 7α-hydroxylase activity paralleled hepatic mRNA levels of this enzyme. These results suggest that a change in hepatic cholesterol metabolism induced by continuous administration of pravastatin maintains a constant net balance of hepatic cholesterol content. In addition, the drug has no deleterious influence on metabolism of bile lipids and acids and related enzymes, except for a transient increase in cholesterol saturation in bile induced by an inappropriate increase in hepatic cholesterol content and a lack of response of cholesterol 7α-hydroxylase activity to changes in hepatic cholesterol content upon abrupt withdrawal of pravastatin.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>7718020</pmid><doi>10.1016/0021-9150(94)90092-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 1994-12, Vol.111 (2), p.183-189 |
| issn | 0021-9150 1879-1484 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77853861 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acyl-coenzyme A cholesterol acyltransferase Animals Bile - drug effects Bile - metabolism Bile Acids and Salts - metabolism Biological and medical sciences Cholesterol 7-alpha-Hydroxylase - drug effects Cholesterol 7-alpha-Hydroxylase - metabolism Cholesterol 7α-hydroxylase Cricetinae General and cellular metabolism. Vitamins Lithogenic bile Liver - drug effects Liver - enzymology Liver - metabolism Male Medical sciences Mesocricetus Microsomes, Liver - enzymology mRNA Pharmacology. Drug treatments Pravastatin - pharmacology Sterol O-Acyltransferase - drug effects Sterol O-Acyltransferase - metabolism |
| title | Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on hepatic cholesterol 7α-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation |
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