Comparative conformation-activity relationships for hormonally- and centrally-acting TRH analogues

Empirical energy calculations have been applied to a series of thyrotrophin‐releasing hormone (TRH) analogues in an attempt to incorporate the conformational parameter into traditional Quantitative Structure‐Activity Relationships (QSAR). A search was made of the potential surface of each analogue u...

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Veröffentlicht in:	International Journal of Peptide and Protein Research 1987-08, Vol.30 (2), p.263-274
Hauptverfasser:	WARD, D.J., FINN, P.W., GRIFFITHS, B.C., ROBSON, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences conformational analysis energetics Fundamental and applied biological sciences. Psychology hypothalamic neuropeptide Models, Molecular Molecular biophysics Protein Conformation Receptors, Neurotransmitter - metabolism Receptors, Thyrotropin-Releasing Hormone Software Structure in molecular biology structure-activity relations Structure-Activity Relationship thyroid-stimulating hormone-releasing hormone Thyrotropin-Releasing Hormone - analogs & derivatives TRH analogues Tridimensional structure
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