Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid
The distribution of amyloid β-protein ending at 40 (Aβ40), 42 (Aβ42), and 43 (Aβ43) were immunocytochemically examined in Alzheimer's brains. A large number of diffuse plaques were stained with Aβ42 antibody (S42), but some were weakly labeled with Aβ43 antibody (S43). Immature and mature plaqu...
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| Veröffentlicht in: | Brain research 1995-12, Vol.702 (1), p.275-278 |
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| container_title | Brain research |
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| creator | Iizuka, Tomomichi Shoji, Mikio Harigaya, Yasuo Kawarabayashi, Takeshi Watanabe, Mitsunori Kanai, Mitsuyasu Hirai, Shunsaku |
| description | The distribution of amyloid β-protein ending at 40 (Aβ40), 42 (Aβ42), and 43 (Aβ43) were immunocytochemically examined in Alzheimer's brains. A large number of diffuse plaques were stained with Aβ42 antibody (S42), but some were weakly labeled with Aβ43 antibody (S43). Immature and mature plaques were labeled with Aβ40 antibody (S40), S42, and S43. Thus, A,β42 is the major component of diffuse plaques, the initial phase of plaque formation, and Aβ43 is present as a minor component. Only Aβ40 is present in cerebrovascular amyloid. |
| doi_str_mv | 10.1016/0006-8993(95)01163-2 |
| format | Article |
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A large number of diffuse plaques were stained with Aβ42 antibody (S42), but some were weakly labeled with Aβ43 antibody (S43). Immature and mature plaques were labeled with Aβ40 antibody (S40), S42, and S43. Thus, A,β42 is the major component of diffuse plaques, the initial phase of plaque formation, and Aβ43 is present as a minor component. Only Aβ40 is present in cerebrovascular amyloid.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(95)01163-2</identifier><identifier>PMID: 8846089</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Alzheimer's disease ; Amyloid beta-Protein Precursor - metabolism ; Amyloid β-protein ; Biological and medical sciences ; Cerebrovascular amyloid ; Cerebrovascular Disorders - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diffuse plaque ; Female ; Humans ; Immunocytochemistry ; Immunohistochemistry ; Male ; Medical sciences ; Neurology ; tau Proteins - analysis ; Temporal Lobe - pathology</subject><ispartof>Brain research, 1995-12, Vol.702 (1), p.275-278</ispartof><rights>1995 Elsevier Science B.V. All rights resreved</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c3f2f5a13fa9ce818b933af9c6bf6662109c3a42040c5d37fe1673d9f9858ca33</citedby><cites>FETCH-LOGICAL-c417t-c3f2f5a13fa9ce818b933af9c6bf6662109c3a42040c5d37fe1673d9f9858ca33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899395011632$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2938563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8846089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iizuka, Tomomichi</creatorcontrib><creatorcontrib>Shoji, Mikio</creatorcontrib><creatorcontrib>Harigaya, Yasuo</creatorcontrib><creatorcontrib>Kawarabayashi, Takeshi</creatorcontrib><creatorcontrib>Watanabe, Mitsunori</creatorcontrib><creatorcontrib>Kanai, Mitsuyasu</creatorcontrib><creatorcontrib>Hirai, Shunsaku</creatorcontrib><title>Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The distribution of amyloid β-protein ending at 40 (Aβ40), 42 (Aβ42), and 43 (Aβ43) were immunocytochemically examined in Alzheimer's brains. A large number of diffuse plaques were stained with Aβ42 antibody (S42), but some were weakly labeled with Aβ43 antibody (S43). Immature and mature plaques were labeled with Aβ40 antibody (S40), S42, and S43. Thus, A,β42 is the major component of diffuse plaques, the initial phase of plaque formation, and Aβ43 is present as a minor component. Only Aβ40 is present in cerebrovascular amyloid.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Protein Precursor - metabolism</subject><subject>Amyloid β-protein</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular amyloid</subject><subject>Cerebrovascular Disorders - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diffuse plaque</subject><subject>Female</subject><subject>Humans</subject><subject>Immunocytochemistry</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>tau Proteins - analysis</subject><subject>Temporal Lobe - pathology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoY8_oGyhkIf6ApfmppJKN0Az-wYCbcR1SqRs7UpW0SWpgfBdfwgfxmabKbnqpqxDudw73noPQE0reUELlW0KIbJTW_KUWrwilkjfsHtpQ1bFGspbcR5sT8hCdl_J9-XKuyRk6U6qVROkN-rWdbscUBvznd7PPqUKIGOIQ4jdsK77e5ZbjULDFU4gpY5emfYoQK04elzQBHoL3cwG8H-2PGQpe9HUHeDv-3EGYIL8oC1LALkifbYivcT_X1TKmin2a47BKHGToc7qxxc2jzdgetnqEHng7Fnh8fC_Q1w_vry8_NVdfPn6-3F41rqVdbRz3zAtLubfagaKq15xbr53svZSSUaIdty0jLXFi4J0HKjs-aK-VUM5yfoGeH3yXCNYrqplCcTCONkKai-k6JVgr2X9B2hHKOiEWsD2ALqdSMnizz2Gy-dZQYtb6zNqNWbsxWpi_9ZnV_-nRf-4nGE6iY1_L_NlxviRlR59tdKGcMKa5EnK9590BgyW0mwDZFBcgOhhCBlfNkMK_97gDI1S4Ww</recordid><startdate>19951208</startdate><enddate>19951208</enddate><creator>Iizuka, Tomomichi</creator><creator>Shoji, Mikio</creator><creator>Harigaya, Yasuo</creator><creator>Kawarabayashi, Takeshi</creator><creator>Watanabe, Mitsunori</creator><creator>Kanai, Mitsuyasu</creator><creator>Hirai, Shunsaku</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19951208</creationdate><title>Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid</title><author>Iizuka, Tomomichi ; Shoji, Mikio ; Harigaya, Yasuo ; Kawarabayashi, Takeshi ; Watanabe, Mitsunori ; Kanai, Mitsuyasu ; Hirai, Shunsaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c3f2f5a13fa9ce818b933af9c6bf6662109c3a42040c5d37fe1673d9f9858ca33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Protein Precursor - metabolism</topic><topic>Amyloid β-protein</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular amyloid</topic><topic>Cerebrovascular Disorders - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diffuse plaque</topic><topic>Female</topic><topic>Humans</topic><topic>Immunocytochemistry</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>tau Proteins - analysis</topic><topic>Temporal Lobe - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iizuka, Tomomichi</creatorcontrib><creatorcontrib>Shoji, Mikio</creatorcontrib><creatorcontrib>Harigaya, Yasuo</creatorcontrib><creatorcontrib>Kawarabayashi, Takeshi</creatorcontrib><creatorcontrib>Watanabe, Mitsunori</creatorcontrib><creatorcontrib>Kanai, Mitsuyasu</creatorcontrib><creatorcontrib>Hirai, Shunsaku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iizuka, Tomomichi</au><au>Shoji, Mikio</au><au>Harigaya, Yasuo</au><au>Kawarabayashi, Takeshi</au><au>Watanabe, Mitsunori</au><au>Kanai, Mitsuyasu</au><au>Hirai, Shunsaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1995-12-08</date><risdate>1995</risdate><volume>702</volume><issue>1</issue><spage>275</spage><epage>278</epage><pages>275-278</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The distribution of amyloid β-protein ending at 40 (Aβ40), 42 (Aβ42), and 43 (Aβ43) were immunocytochemically examined in Alzheimer's brains. A large number of diffuse plaques were stained with Aβ42 antibody (S42), but some were weakly labeled with Aβ43 antibody (S43). Immature and mature plaques were labeled with Aβ40 antibody (S40), S42, and S43. Thus, A,β42 is the major component of diffuse plaques, the initial phase of plaque formation, and Aβ43 is present as a minor component. Only Aβ40 is present in cerebrovascular amyloid.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8846089</pmid><doi>10.1016/0006-8993(95)01163-2</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Amyloid β-protein Biological and medical sciences Cerebrovascular amyloid Cerebrovascular Disorders - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diffuse plaque Female Humans Immunocytochemistry Immunohistochemistry Male Medical sciences Neurology tau Proteins - analysis Temporal Lobe - pathology |
| title | Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid |
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