Amlodipine therapy corrects renal abnormalities encountered in the hypertensive state
Calcium antagonists may increase glomerular filtration rate and renal plasma flow by antagonizing the intrarenal effects of angiotensin II and/or norepinephrine. We prospectively studied the effects of amlodipine, a once-a-day dihydropyridine calcium channel antagonist, in 19 patients with essential...
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| Veröffentlicht in: | American journal of kidney diseases 1987-12, Vol.10 (6), p.446-451 |
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| container_end_page | 451 |
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| container_title | American journal of kidney diseases |
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| creator | Reams, G P Lau, A Hamory, A Bauer, J H |
| description | Calcium antagonists may increase glomerular filtration rate and renal plasma flow by antagonizing the intrarenal effects of angiotensin II and/or norepinephrine. We prospectively studied the effects of amlodipine, a once-a-day dihydropyridine calcium channel antagonist, in 19 patients with essential hypertension. Studies were performed after 4 weeks of placebo and 6 weeks of amlodipine therapy, and included the assessment of systolic and diastolic BP, renal clearances of inulin and p-aminohippurate, and determination of body fluid composition. Systolic and diastolic BPs were reduced following 6 weeks of amlodipine monotherapy. In spite of significant decreases in mean arterial pressure, there were increases in inulin clearance (+ 13%), and p-aminohippurate clearance (+ 19%). Filtration fraction was not changed. Renal vascular resistance was decreased (-25%). Total blood volume, extracellular fluid volume, and total body water and body weight were not changed. We conclude that amlodipine therapy has the potential to reverse renal abnormalities encountered in the hypertensive state. |
| doi_str_mv | 10.1016/S0272-6386(87)80191-9 |
| format | Article |
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We prospectively studied the effects of amlodipine, a once-a-day dihydropyridine calcium channel antagonist, in 19 patients with essential hypertension. Studies were performed after 4 weeks of placebo and 6 weeks of amlodipine therapy, and included the assessment of systolic and diastolic BP, renal clearances of inulin and p-aminohippurate, and determination of body fluid composition. Systolic and diastolic BPs were reduced following 6 weeks of amlodipine monotherapy. In spite of significant decreases in mean arterial pressure, there were increases in inulin clearance (+ 13%), and p-aminohippurate clearance (+ 19%). Filtration fraction was not changed. Renal vascular resistance was decreased (-25%). Total blood volume, extracellular fluid volume, and total body water and body weight were not changed. 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We prospectively studied the effects of amlodipine, a once-a-day dihydropyridine calcium channel antagonist, in 19 patients with essential hypertension. Studies were performed after 4 weeks of placebo and 6 weeks of amlodipine therapy, and included the assessment of systolic and diastolic BP, renal clearances of inulin and p-aminohippurate, and determination of body fluid composition. Systolic and diastolic BPs were reduced following 6 weeks of amlodipine monotherapy. In spite of significant decreases in mean arterial pressure, there were increases in inulin clearance (+ 13%), and p-aminohippurate clearance (+ 19%). Filtration fraction was not changed. Renal vascular resistance was decreased (-25%). Total blood volume, extracellular fluid volume, and total body water and body weight were not changed. We conclude that amlodipine therapy has the potential to reverse renal abnormalities encountered in the hypertensive state.</description><subject>Adult</subject><subject>Aged</subject><subject>Amlodipine</subject><subject>Blood Pressure - drug effects</subject><subject>Body Fluids - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Drug Evaluation</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nifedipine - analogs & derivatives</subject><subject>Nifedipine - pharmacology</subject><subject>Nifedipine - therapeutic use</subject><subject>Prospective Studies</subject><subject>Renal Circulation - drug effects</subject><subject>Vascular Resistance - drug effects</subject><issn>0272-6386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MtKAzEUBuAslFqrj1CYlehiNJfJZZaleIOCC-06JJkzNDKTGZNU6NvbG64OHP7_HPgQmhP8SDART5-YSloKpsS9kg8Kk5qU9QWa_q-v0HVK3xjjmgkxQRNaC0K5mKL1ou-Gxo8-QJE3EM24K9wQI7icigjBdIWxYYi96Xz2kAoIbtiGDBGawodDp9jsRogZQvK_UKRsMtygy9Z0CW7Pc4bWL89fy7dy9fH6vlysSse4yGVtXaOsta0Bg1UlOaW8sg0xVJqaAONWSl65SlSkJbxV0EpFhGDMVZaQmrIZujvdHePws4WUde-Tg64zAYZt0lIqTvZC-yA_BV0cUorQ6jH63sSdJlgfCPWRUB-stJL6SKjrfW9-frC1PTT_rbMf-wNwv3AP</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>Reams, G P</creator><creator>Lau, A</creator><creator>Hamory, A</creator><creator>Bauer, J H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871201</creationdate><title>Amlodipine therapy corrects renal abnormalities encountered in the hypertensive state</title><author>Reams, G P ; Lau, A ; Hamory, A ; Bauer, J H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-9bcd8bbbfaea084752254bd1a27a91e35b7754c4641f15f8ef7816633c4b11923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amlodipine</topic><topic>Blood Pressure - drug effects</topic><topic>Body Fluids - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Drug Evaluation</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nifedipine - analogs & derivatives</topic><topic>Nifedipine - pharmacology</topic><topic>Nifedipine - therapeutic use</topic><topic>Prospective Studies</topic><topic>Renal Circulation - drug effects</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reams, G P</creatorcontrib><creatorcontrib>Lau, A</creatorcontrib><creatorcontrib>Hamory, A</creatorcontrib><creatorcontrib>Bauer, J H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reams, G P</au><au>Lau, A</au><au>Hamory, A</au><au>Bauer, J H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amlodipine therapy corrects renal abnormalities encountered in the hypertensive state</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>10</volume><issue>6</issue><spage>446</spage><epage>451</epage><pages>446-451</pages><issn>0272-6386</issn><abstract>Calcium antagonists may increase glomerular filtration rate and renal plasma flow by antagonizing the intrarenal effects of angiotensin II and/or norepinephrine. We prospectively studied the effects of amlodipine, a once-a-day dihydropyridine calcium channel antagonist, in 19 patients with essential hypertension. Studies were performed after 4 weeks of placebo and 6 weeks of amlodipine therapy, and included the assessment of systolic and diastolic BP, renal clearances of inulin and p-aminohippurate, and determination of body fluid composition. Systolic and diastolic BPs were reduced following 6 weeks of amlodipine monotherapy. In spite of significant decreases in mean arterial pressure, there were increases in inulin clearance (+ 13%), and p-aminohippurate clearance (+ 19%). Filtration fraction was not changed. Renal vascular resistance was decreased (-25%). Total blood volume, extracellular fluid volume, and total body water and body weight were not changed. We conclude that amlodipine therapy has the potential to reverse renal abnormalities encountered in the hypertensive state.</abstract><cop>United States</cop><pmid>2961256</pmid><doi>10.1016/S0272-6386(87)80191-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of kidney diseases, 1987-12, Vol.10 (6), p.446-451 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Amlodipine Blood Pressure - drug effects Body Fluids - metabolism Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Drug Evaluation Glomerular Filtration Rate - drug effects Hemodynamics - drug effects Humans Hypertension - drug therapy Hypertension - physiopathology Kidney - drug effects Kidney - physiopathology Male Middle Aged Nifedipine - analogs & derivatives Nifedipine - pharmacology Nifedipine - therapeutic use Prospective Studies Renal Circulation - drug effects Vascular Resistance - drug effects |
| title | Amlodipine therapy corrects renal abnormalities encountered in the hypertensive state |
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